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  • Wiley  (127)
  • Zhang, Meng  (127)
  • 2020-2024  (127)
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  • Wiley  (127)
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  • 2020-2024  (127)
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  • 1
    Online Resource
    Online Resource
    Front Cover: Chemical Constituents of the Deep‐sea Gammarid Shrimp‐Derived Fungus Penicillium citrinum XIA‐16 (Chem. Biodiversity 11/2023)
    Wiley ; 2023
    In:  Chemistry & Biodiversity Vol. 20, No. 11 ( 2023-11)
    Details
    In: Chemistry & Biodiversity, Wiley, Vol. 20, No. 11 ( 2023-11)
    Type of Medium: Online Resource
    ISSN: 1612-1872 , 1612-1880
    URL: Issue
    URL: Article
    DOI: 10.1002/cbdv.v20.11
    DOI: 10.1002/cbdv.202301749
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2139001-0
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Chemical Constituents of the Deep‐sea Gammarid Shrimp‐Derived Fungus Penicillium citrinum XIA‐16
    Wiley ; 2023
    In:  Chemistry & Biodiversity Vol. 20, No. 11 ( 2023-11)
    Details
    In: Chemistry & Biodiversity, Wiley, Vol. 20, No. 11 ( 2023-11)
    Abstract: One new alkaloid, ( S )‐2‐acetamido‐4‐(2‐(methylamino)phenyl)‐4‐oxobutanoic acid ( 1 ), was isolated from the deep‐sea‐derived Penicillium citrinum XIA‐16, together with 25 known compounds including ten polyketones ( 2–11 ), eight alkaloids ( 12–19 ), six steroids ( 20–25 ), and a fatty acid ( 26 ). Their planar and relative structures were determined by an analysis of 1D and 2D nuclear magnetic resonance (NMR) as well as high resolution electrospray ionization mass spectroscopy (HR‐ESI‐MS) data. The absolute configuration of 1 was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Penicitrinol B ( 6 ) significantly inhibited RSL3‐induced ferroptosis (EC 50 =2.0 μM) by reducing lipid peroxidation and heme oxygenase 1 (HMOX1) expression. Under the concentration of 10 μM, penicitrinol A ( 7 ) was able to inhibit cuproptosis with the cell viabilities of 68.2 % compared to the negative control (copper and elesclomol) with the cell viabilities of 14.8 %.
    Type of Medium: Online Resource
    ISSN: 1612-1872 , 1612-1880
    URL: Issue
    URL: Article
    DOI: 10.1002/cbdv.v20.11
    DOI: 10.1002/cbdv.202301507
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2139001-0
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Liquid biopsy: circulating tumor DNA monitors neoadjuvant chemotherapy response and prognosis in stage II / III gastric cancer
    Wiley ; 2023
    In:  Molecular Oncology Vol. 17, No. 9 ( 2023-09), p. 1930-1942
    Details
    In: Molecular Oncology, Wiley, Vol. 17, No. 9 ( 2023-09), p. 1930-1942
    Abstract: A good response to neoadjuvant chemotherapy (NACT) is strongly associated with a higher curative resection rate and favorable outcomes for patients with gastric cancer (GC). We examined the utility of serial circulating tumor DNA (ctDNA) testing for monitoring NACT response and prognosis in stage II–III GC. Seventy‐nine patients were enrolled to receive two cycles of NACT following gastrectomy with D2‐lymphadenectomy. Plasma at baseline, post‐NACT, and after surgery, and tissue at pretreatment and surgery were collected. We used a 425‐gene panel to detect genomic alterations (GAs). Results show that the mean cell‐free DNA concentration of patients with clinical stage III was significantly higher than patients with stage II (15.43 ng·mL −1 vs 14.40 ng·mL −1 ). After receiving NACT and surgery, the overall detection rate of ctDNA gradually reduced (59.5%, 50.8%, and 47.4% for baseline, post‐NACT, and postsurgery). The maximum variant allele frequency (max‐VAF) and the number of GAs decreased from 0.50% to 0.08% and from 2.9 to 1.7 after NACT. For patients with a partial response after NACT, the max‐VAF and the number of GAs declined significantly, but they increased for patients with progressive disease. Patients with detectable ctDNA at baseline, after NACT, or after surgery have a worse overall survival (OS) than patients with undetectable ctDNA. The estimated 3‐year OS was 73% for the post‐NACT ctDNA‐negative patients and 34% for ctDNA‐positive. Patients with perpetual negative ctDNA before and after NACT have the best prognosis. In conclusion, ctDNA was proposed as a potential biomarker to predict prognosis and monitor the NACT response for stage II–III GC patients.
    Type of Medium: Online Resource
    ISSN: 1574-7891 , 1878-0261
    URL: Issue
    URL: Article
    DOI: 10.1002/mol2.v17.9
    DOI: 10.1002/1878-0261.13481
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2322586-5
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  • 4
    Online Resource
    Online Resource
    High‐resolution magnetic resonance imaging of acute intracranial artery thrombus
    Wiley ; 2023
    In:  European Journal of Neurology Vol. 30, No. 10 ( 2023-10), p. 3172-3181
    Details
    In: European Journal of Neurology, Wiley, Vol. 30, No. 10 ( 2023-10), p. 3172-3181
    Abstract: The development of high‐resolution magnetic resonance imaging (HR‐MRI) has enabled submillimeter‐level evaluation of intracranial artery plaque and luminal thrombus. We sought to investigate the value of HR‐MRI in assessing the pathogenesis of acute intracranial artery thrombus. Methods We examined the presence of intracranial thrombus on three‐dimensional T1‐weighted HR‐MRI in acute ischemic stroke patients with intracranial artery occlusion on magnetic resonance angiography. We defined two thrombus‐related HR‐MRI features (peri‐thrombus plaque and distal residual flow beyond the thrombus) and analyzed their association with potential embolic sources. Results Luminal thrombus and a shrunken artery without luminal thrombus were detected in 162 (96.4%) and six (3.6%) of 168 patients with intracranial artery occlusion, respectively. Among 111 patients with culprit major artery thrombus, peri‐thrombus plaques were observed in 46.8% and distal residual flow beyond the thrombus in 64.0%. Patients with peri‐thrombus plaque had a higher prevalence of diabetes (44.2% vs. 25.4%; p  = 0.037), a lower prevalence of potential sources of cardioembolism (0% vs. 16.9%; p  = 0.002), and a nonsignificantly lower prevalence of potential embolic sources from extracranial arteries (9.6% vs. 20.3%; p  = 0.186) than those without. Patients with distal residual flow beyond the thrombus had a lower prevalence of potential sources of cardioembolism (1.4% vs. 22.5%; p   〈  0.001) and smaller infarct volumes (5.0 [1.4–12.7] mL vs. 16.6 [2.4–94.6]  mL; p  = 0.012) than those without. Conclusions Our study showed that HR‐MRI helps clarify the pathogenesis of acute intracranial artery thrombus. The presence of peri‐thrombus plaque and distal residual flow beyond the thrombus favor the stroke mechanism of atherosclerosis rather than cardioembolism.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    URL: Article
    DOI: 10.1111/ene.v30.10
    DOI: 10.1111/ene.15985
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020241-6
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  • 5
    Online Resource
    Online Resource
    Myricitrin promotes osteogenesis and prevents ovariectomy bone mass loss via the PI3K/AKT signalling pathway
    Wiley ; 2023
    In:  Journal of Cellular Biochemistry Vol. 124, No. 8 ( 2023-08), p. 1155-1172
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 124, No. 8 ( 2023-08), p. 1155-1172
    Abstract: This study aimed to explore the effect of myricitrin on osteoblast differentiation in mice immortalised bone marrow mesenchymal stem cells (imBMSCs). Additionally, ovariectomy (OVX) mice were employed to examine the effect of myricitrin on bone trabecular loss in vivo. The effect of myricitrin on the proliferation of imBMSCs was evaluated using a cell counting kit‐8 assay. Alizarin red staining, alkaline phosphatase staining were performed to elucidate osteogenesis. Furthermore, qRT‐PCR and western blot determined the expression of osteo‐specific genes and proteins. To screen for candidate targets, mRNA transcriptome genes were sequenced using bioinformatics analyses. Western blot and molecular docking analysis were used to examine target signalling markers. Moreover, rescue experiments were used to confirm the effect of myricitrin on the osteogenic differentiation of imBMSCs. OVX mice were also used to estimate the delay capability of myricitrin on bone trabecular loss in vivo using western blot, micro‐CT, tartaric acid phosphatase (Trap) staining, haematoxylin and eosin staining, Masson staining and immunochemistry. In vitro, myricitrin significantly enhanced osteo‐specific genes and protein expression and calcium deposition. Moreover, mRNA transcriptome gene sequencing and molecular docking analysis revealed that this enhancement was accompanied by an upregulation of the PI3K/AKT signalling pathway. Furthermore, copanlisib, a PI3K inhibitor, partially reversed the osteogenesis promotion induced by myricitrin. In vivo, western blot, micro‐CT, hematoxylin and eosin staining, Masson staining, Trap staining and immunochemistry revealed that bone trabecular loss rate was significantly alleviated in the myricitrin low‐ and high‐dose groups, with an increased expression of osteopontin, osteoprotegerin, p‐PI3K and p‐AKT compared to the OVX group. Myricitrin enhances imBMSC osteoblast differentiation and attenuate bone mass loss partly through the upregulation of the PI3K/AKT signalling pathway. Thus, myricitrin has therapeutic potential as an antiosteoporosis drug.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v124.8
    DOI: 10.1002/jcb.30439
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Achieving 78.2 % Faraday Efficiency for Electrochemical Ammonia Production Via Covalent Modification of CNTs with B 4 C
    Wiley ; 2024
    In:  ChemCatChem
    Details
    In: ChemCatChem, Wiley
    Abstract: Electrochemical reduction of N 2 to NH 3 provides an alternative to the Haber‐Bosch process for sustainable NH 3 production driven by renewable electricity. Here, we reported carbon nanotubes (CNTs) covalently modified with boron carbide (B 4 C) as a nonmetallic catalyst for efficient electrochemical nitrogen reduction reaction (NRR) under ambient conditions. The structure of the catalyst was characterized by transmission electron microscopy (TEM), X‐ray diffraction (XRD), elemental mapping, X‐ray photoelectron spectroscopy (XPS) and Raman spectroscopy. The catalyst held a superior selectivity for NRR with high Faraday efficiency of 78.2 % accompanying with NH 3 yield rate of 14.0 μg mg −1 cat. h −1 under the condition of 0.1 M Na 2 SO 4 and −0.6 V vs. RHE. Electrochemical experiments including cyclic voltammetry, electrochemical impedance spectroscopy and Tafel polarization curves were performed to explain the best electrochemical properties of B 4 C/CNTs among the samples. This work demonstrates that the strategy of covalent modification plays an important role to improve the selectivity of electrochemical NRR catalyst, thus allowing the reactions to proceed more efficiently.
    Type of Medium: Online Resource
    ISSN: 1867-3880 , 1867-3899
    URL: Article
    DOI: 10.1002/cctc.202400115
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2501161-3
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  • 7
    Online Resource
    Online Resource
    Activated autophagy restored the impaired frequency and function of regulatory T cells in chronic prostatitis
    Wiley ; 2021
    In:  The Prostate Vol. 81, No. 1 ( 2021-01), p. 29-40
    Details
    In: The Prostate, Wiley, Vol. 81, No. 1 ( 2021-01), p. 29-40
    Abstract: Chronic prostatitis or chronic pelvic pain syndrome (CP/CPPS) is a disease with an unclear pathogenesis. Recent studies have reported that regulatory T (Treg) cells might be involved in the development of CP/CPPS. In this study we aimed to examine the functional role of Treg cells and explore the possible regulatory mechanism of Treg cells in CP/CPPS. Methods An experimental autoimmune prostatitis (EAP) mouse model was constructed; the numbers and functions of Treg cells in the EAP and control groups were tested. Then, cell differentiation experiments were conducted to evaluate the regulatory effect of autophagy on Treg cell differentiation. Furthermore, autologous CD4 + CD25 ‐ cells and CD4 + CD25 + cells from the two groups were magnetically sorted and cocultured to observe differences in cellular inhibitory functions. Finally, in an in vivo experiment, rapamycin was intraperitoneally injected into EAP mice for 4 weeks to observe the therapeutic effects. Results We found that the number and function of Treg cells in the EAP group were diminished compared to those in the control group. Meanwhile, the tolerance of pain in EAP mice had also decreased. Moreover, after using the autophagy activator rapamycin, the expression of the inflammatory cytokines interleukin‐1β was decreased and the pain symptoms were alleviated. A mechanistic study found that autophagy activation promoted the differentiation of Treg and increased the suppressive functions of Treg cells, along with the elevated expression of GATA‐3 and cytotoxic T lymphocyte antigen 4 (CTLA‐4). Furthermore, in vivo administration of the autophagy activator rapamycin had similar effects on recovering the frequency and function of Treg cells as well as the expression of GATA‐3 and CTLA‐4. Conclusion The impaired frequency and function of Treg cells may contribute to the progression of CP/CPPS, and autophagy is a protective mechanism that promotes the differentiation of Treg cells and restores the suppressive functions of Treg cells. Autophagy may be a novel therapeutic option for patients with CP/CPPS.
    Type of Medium: Online Resource
    ISSN: 0270-4137 , 1097-0045
    URL: Issue
    URL: Article
    DOI: 10.1002/pros.v81.1
    DOI: 10.1002/pros.24073
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1494709-2
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  • 8
    Online Resource
    Online Resource
    Angiotensin‐(1‐7) mitigated angiotensin II‐induced abdominal aortic aneurysms in apolipoprotein E‐knockout mice
    Wiley ; 2020
    In:  British Journal of Pharmacology Vol. 177, No. 8 ( 2020-04), p. 1719-1734
    Details
    In: British Journal of Pharmacology, Wiley, Vol. 177, No. 8 ( 2020-04), p. 1719-1734
    Abstract: To test the hypothesis that angiotensin‐(1‐7) [Ang‐(1‐7)] may attenuate abdominal aortic aneurysm (AAA) via inhibiting vascular inflammation, extracellular matrix degradation, and smooth muscle cell (SMC) apoptosis, an animal model of AAA was established by angiotensin II (Ang II) infusion to apolipoprotein E‐knockout (ApoE ‐/‐ ) mice. Experimental Approach All mice and cultured SMCs or macrophages were divided into control, Ang II‐treated, Ang II + Ang‐(1‐7)‐treated, Ang II + Ang‐(1‐7) + A779‐treated and Ang II + Ang‐(1‐7) + PD123319‐treated groups respectively. In vivo, aortic mechanics and serum lipids were assessed. Ex vivo, AAA were examined by histology, immunohistochemistry and zymography. Cultured cells were analysed by RT‐PCR, western blots and TUNEL assays. Key Results In vivo, Ang‐(1‐7) reduced the incidence and severity of AAA induced by Ang II infusion, by inhibiting macrophage infiltration, attenuating expression of IL‐6, TNF‐α, CCL2 and MMP2, and decreasing SMC apoptosis in abdominal aortic tissues. Addition of A779 or PD123319 reversed Ang‐(1‐7)‐mediated beneficial effects on AAA. In vitro, Ang‐(1‐7) decreased expression of mRNA for IL‐6, TNF‐α, and CCL2 induced by Ang II in macrophages. In addition, Ang‐(1‐7) suppressed apoptosis and MMP2 expression and activity in Ang II‐treated SMCs. These effects were accompanied by inhibition of the ERK1/2 signalling pathways via Ang‐(1‐7) stimulation of Mas and AT 2 receptors. Conclusion and Implications Ang‐(1‐7) treatment attenuated Ang II‐induced AAA via inhibiting vascular inflammation, extracellular matrix degradation, and SMC apoptosis. Ang‐(1‐7) may provide a novel and promising approach to the prevention and treatment of AAA.
    Type of Medium: Online Resource
    ISSN: 0007-1188 , 1476-5381
    URL: Issue
    URL: Article
    DOI: 10.1111/bph.v177.8
    DOI: 10.1111/bph.14906
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2029728-2
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    Synthesis, characterizations and kinetics of MOF‐5 as herbicide vehicle and its controlled release in PVA/ST biodegradable composite membranes
    Wiley ; 2022
    In:  Zeitschrift für anorganische und allgemeine Chemie Vol. 648, No. 9 ( 2022-05-13)
    Details
    In: Zeitschrift für anorganische und allgemeine Chemie, Wiley, Vol. 648, No. 9 ( 2022-05-13)
    Abstract: Polyvinyl alcohol/starch based composite membranes containing herbicide‐loaded metal‐organic‐framework (MOF‐5) was successfully synthesized by electrostatic spraying technique. Several main parameters affecting the adsorption of MOF‐5 were studied, including the initial concentration of the herbicide solution, adsorption time, and temperature. Under optimal conditions, herbicide‐loaded MOF‐5 was successfully synthesized and the main properties were characterized by Scanning Electron Microscopy (SEM), X‐Ray Diffraction (XRD), Fourier Transform Infrared Spectrometer (FTIR), Thermogravimetric Analysis (TG), and Brunauer‐Emmett‐Teller (BET), respectively. The results showed that the adsorption capacity of MOF‐5 at optimal conditions was 60.12wt%±0.61 % for atrazine. The sustained release effect of the AT@MOF‐5/PVA/ST composite membranes was reliable, and the cumulative release rate was about 50 % for 15 h. The release behaviour of AT from AT@MOF‐5/PVA/ST composite membranes was first dominated by the mechanism of Fickian diffusion and then by the mechanism of matrix erosion. The main advantages of agricultural herbicide film can be attributed to the eco‐friendly, biodegradable, and persistence of herbicide.
    Type of Medium: Online Resource
    ISSN: 0044-2313 , 1521-3749
    URL: Issue
    URL: Article
    DOI: 10.1002/zaac.v648.9
    DOI: 10.1002/zaac.202100252
    RVK:
    VA 8102
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 201094-X
    detail.hit.zdb_id: 1481139-X
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  • 10
    Online Resource
    Online Resource
    Establishment of a five‐enzalutamide‐resistance‐related‐gene‐based classifier for recurrence‐free survival predicting of prostate cancer
    Wiley ; 2022
    In:  Journal of Cellular and Molecular Medicine Vol. 26, No. 21 ( 2022-11), p. 5379-5390
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 26, No. 21 ( 2022-11), p. 5379-5390
    Abstract: To identify prostate cancer (PCa) patients with a high risk of recurrence is critical before delivering adjuvant treatment. We developed a classifier based on the Enzalutamide treatment resistance‐related genes to assist the currently available staging system in predicting the recurrence‐free survival (RFS) prognosis of PCa patients. We overlapped the DEGs from two datasets to obtain a more convincing Enzalutamide‐resistance‐related‐gene (ERRG) cluster. The five‐ERRG‐based classifier obtained good predictive values in both the training and validation cohorts. The classifier precisely predicted RFS of patients in four cohorts, independent of patient age, pathological tumour stage, Gleason score and PSA levels. The classifier and the clinicopathological factors were combined to construct a nomogram, which had an increased predictive accuracy than that of each variable alone. Besides, we also compared the differences between high‐ and low‐risk subgroups and found their differences were enriched in cancer progression‐related pathways. The five‐ERRG‐based classifier is a practical and reliable predictor, which adds value to the existing staging system for predicting the RFS prognosis of PCa after radical prostatectomy, enabling physicians to make more informed treatment decisions concerning adjuvant therapy.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v26.21
    DOI: 10.1111/jcmm.17554
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2076114-4
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