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  • Hindawi Limited  (18)
  • Zhang, Lei  (18)
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  • Hindawi Limited  (18)
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  • 1
    Online Resource
    Online Resource
    Electrical Fire Dynamic Risk Assessment for High-Rise Buildings Based on Variable Fuzzy Set Theory and Bayesian Network
    Hindawi Limited ; 2023
    In:  Mathematical Problems in Engineering Vol. 2023 ( 2023-2-22), p. 1-16
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2023 ( 2023-2-22), p. 1-16
    Abstract: High-rise buildings fires are far more harmful than ordinary fires. In this regard, fire risk assessment is an important way to control fire risk and reduce losses. This study presents a comprehensive model to electrical fire dynamic risk assessment of high-rise buildings based on a Bayesian network (BN) and a variable fuzzy set theory (VFST). Firstly, electric system, safety management, and other factors were comprehensively analyzed based on three categories: hazard sources identification (HSI), fault tree (FT) analysis, and VFST. A high-rise building electrical fire dynamic risk assessment model was established based on a BN. Secondly, the prior probability of BN root nodes was determined by VFST, and the conditional probability table (CPT) was determined by the analytic hierarchy process (AHP) and decomposition method. On that basis, the quantitative inference and sensitivity analysis can be performed on the electrical fire risks of high-rise buildings in combination with the variable fuzzy Bayesian network (VFBN) inference. Finally, a high-rise building in Wuhan, China, was used as an example for verification. The results show that the proposed method can realize dynamic risk assessment of electrical fires in high-rise buildings. This study provides a new method for fire risk assessment of high-rise buildings to reduce the possibility of fire.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2023/9068958
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Particle-in-cell simulations of current loss in magnetically insulated transmission line with inductive helical support
    Hindawi Limited ; 2019
    In:  Laser and Particle Beams Vol. 37, No. 03 ( 2019-09), p. 301-310
    Details
    In: Laser and Particle Beams, Hindawi Limited, Vol. 37, No. 03 ( 2019-09), p. 301-310
    Abstract: High inductive helical support provides a solution to controlling the alignment error of inner electrodes in magnetically insulated transmission lines (MITLs). Three-dimensional particle-in-cell simulations were performed to examine the current loss mechanism and the effects of structural parameters on electron flow in an MITL with a helical inductor. An empirical expression related to the ratio of electron current loss to anode current and the ratio of anode current to self-limited current was obtained. Electron current loss caused by helical inductor with different structures was displayed. The results indicate that the current loss in an MITL, near an inductive helical support, comprises both the inductor current and the electron current loss. The non-uniform structure and current of a helical inductor cause an abrupt change in the magnetic field near the helical support, which leads to anomalous behavior and current loss of electron flow. In addition, current loss in the inductive helical-supported MITL is negligible when the inductance of the support is sufficiently high. This work facilitates the estimation of electron current loss caused by the inductive helical support in MITLs.
    Type of Medium: Online Resource
    ISSN: 0263-0346 , 1469-803X
    URL: Article
    DOI: 10.1017/S0263034619000508
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2021816-3
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  • 3
    Online Resource
    Online Resource
    Calycosin Alleviates Doxorubicin-Induced Cardiotoxicity and Pyroptosis by Inhibiting NLRP3 Inflammasome Activation
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-1-5), p. 1-15
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-1-5), p. 1-15
    Abstract: Calycosin (CAL) is the main active component present in Astragalus and reportedly possesses diverse pharmacological properties. However, the cardioprotective effect and underlying mechanism of CAL against doxorubicin- (DOX-) induced cardiotoxicity need to be comprehensively examined. Herein, we aimed to investigate whether the cardioprotective effects of CAL are related to its antipyroptotic effect. A cardiatoxicity model was established by stimulating H9c2 cells and C57BL/6J mice using DOX. In vitro, CAL increased H9c2 cell viability and decreased DOX-induced pyroptosis via NLRP3, caspase-1, and gasdermin D signaling pathways in a dose-dependent manner. In vivo, CAL-DOX cotreatment effectively suppressed DOX-induced cytotoxicity as well as inflammatory and cardiomyocyte pyroptosis via the same molecular mechanism. Next, we used nigericin (Nig) and NLRP3 forced overexpression to determine whether CAL imparts antipyroptotic effects by inhibiting the NLRP3 inflammasome in vitro. Furthermore, CAL suppressed DOX-induced mitochondrial oxidative stress injury in H9c2 cells by decreasing the generation of reactive oxygen species and increasing mitochondrial membrane potential and adenosine triphosphate. Likewise, CAL attenuated the DOX-induced increase in malondialdehyde content and decreased superoxide dismutase and glutathione peroxidase activities in H9c2 cells. In vivo, CAL afforded a protective effect against DOX-induced cardiac injury by improving myocardial function, inhibiting brain natriuretic peptide, and improving the changes of the histological morphology of DOX-treated mice. Collectively, our findings confirmed that CAL alleviates DOX-induced cardiotoxicity and pyroptosis by inhibiting NLRP3 inflammasome activation in vivo and in vitro.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/1733834
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 4
    Online Resource
    Online Resource
    Cox-2 Antagonizes the Protective Effect of Sevoflurane on Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis through Inhibiting the Akt Pathway
    Hindawi Limited ; 2021
    In:  Disease Markers Vol. 2021 ( 2021-12-7), p. 1-6
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2021 ( 2021-12-7), p. 1-6
    Abstract: Objective. To uncover the protective role of sevoflurane on hypoxia/reoxygenation-induced cardiomyocyte apoptosis through the protein kinase B (Akt) pathway. Methods. An in vitro hypoxia/reoxygenation (H/R) model was established in cardiomyocyte cell line H9c2. Sevoflurane (SEV) was administrated in H9c2 cells during the reoxygenation period. Viability, layered double hydroxide (LDH) release, and apoptosis in H9c2 cells were determined to assess H/R-induced cell damage. Relative levels of apoptosis-associated genes were examined. Moreover, phosphorylation of Akt was determined. Results. H/R injury declined viability and enhanced LDH release and apoptotic rate in H9c2 cells. Cyclooxygenase-2 (Cox-2) was upregulated following H/R injury, which was partially reversed by SEV treatment. In addition, SEV treatment reversed changes in viability and LDH release owing to H/R injury in H9c2 cells, which were further aggravated by overexpression of Cox-2. The Akt pathway was inhibited in H9c2 cells overexpressing Cox-2. Conclusions. Sevoflurane protects cardiomyocyte damage following H/R via the Akt pathway, and its protective effect was abolished by overexpression of Cox-2.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2021/4114593
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2033253-1
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  • 5
    Online Resource
    Online Resource
    Experimental Study on the Vibration Characteristics of Dangerous Rock Mass under Constant Micromotion
    Hindawi Limited ; 2023
    In:  Advances in Civil Engineering Vol. 2023 ( 2023-3-7), p. 1-11
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2023 ( 2023-3-7), p. 1-11
    Abstract: In mountainous areas, dangerous rock mass collapse is a serious threat to human life and property safety. However, how to effectively prevent and control the instability of dangerous rock mass is still an urgent unsolved problem. In this study, the dynamic characteristics of dangerous rock mass under constant micromotion were analysed from the perspective of elastic wave propagation. When the slip plane of the dangerous rock mass is damaged, many micropores and cracks will appear in the medium composed of the slip surface. With constant micromotion as the vibration source, the elastic wave propagates to the dangerous rock mass through the damaged slip plane. The high-frequency components of elastic waves scatter in pores and fissures, where energy dissipates. According to this characteristic, a laboratory simulation experiment was designed. In the experiment, the damage process of the slip plane was simulated by the freeze‒thaw process of frozen hydrosol. The experimental analysis showed that the centre frequency of the high-frequency part of the dangerous rock mass model and bedrock mass model decreased as the frozen surface continued to melt. As the dangerous rock mass model and the bedrock mass model continued to fit, the centre frequency of the high-frequency part of the two rock mass models rebounded. This phenomenon showed that the damage degree of the slip plane between the dangerous rock mass and the bed rock mass can be effectively reflected by the centre frequency of the high-frequency part of the two rock mass models. During the experiment, the dangerous rock mass did not slide in the whole process, indicating that the deformation index has difficulty reflecting the stability of the hidden dangerous rock mass. In addition, the application conditions of using the natural frequency characteristics of dangerous rock mass and the scattering characteristics of elastic wave in the damage identification of structural plane were analysed: (1) when the structural plane has macrofracture, the change of natural frequency of dangerous rock mass should be used to analyse the damage degree of structural plane; (2) when there is no macrofracture of the structural plane, the characteristics of elastic wave scattering should be used to analyse the damage degree of the structural plane. This study provided a new idea for the prevention and control of dangerous rock masses and is expected to provide a useful reference for the automation of dangerous rock mass prevention and control.
    Type of Medium: Online Resource
    ISSN: 1687-8094 , 1687-8086
    URL: Article
    DOI: 10.1155/2023/6323929
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2449760-5
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  • 6
    Online Resource
    Online Resource
    Growth Pattern of Clear Cell Renal Cell Carcinoma in Patients with Delayed Surgical Intervention: Fast Growth Rate Correlates with High Grade and May Result in Poor Prognosis
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Abstract: Objectives. Previous studies revealed an unclear correlation between the growth rate of renal cell carcinoma (RCC) and tumor grade and did not focus on certain histological subtype. This report investigated the correlation between the growth rate and tumor grade in clear cell RCC (ccRCC). Methods . We reviewed 60 patients with 61 ccRCC confirmed by delayed surgeries after at least 12 months of active surveillance. The linear growth rate (LGR), volumetric growth rate (VGR), and volume doubling time (VDT) were calculated, and their correlations with clinicopathologic characteristics were analyzed. Results . The mean LGR, VGR, and VDT were 0.86 (range 0–4.74) cm/year, 20.96 (range 0.31–211.93) cm 3 /year, and 667 (range 33–3321) days, respectively. ccRCCs with high grade had greater LGR ( P 〈 0.001 ) and VGR ( P = 0.001 ) and lower VDT ( P = 0.017 ) than ccRCCs with low grade. Grade (OR = 5.185, P = 0.004 ) was the only independent risk factor of LGR 〉 0.5 cm/year, and grade (OR = 3.006, P = 0.046 ) and initial size (OR = 0.392, P = 0.004 ) were independent risk factors of VDT 〈 1 year. Five patients developed metastasis after surgery with LGR 〉 0.5 cm/yr altogether; of them, four had cancer-related death by the last follow-up. Conclusions . Fast growth rate of ccRCC is significantly correlated with high tumor grade and may result in poor prognosis, especially for those with LGR 〉 0.5 cm/yr.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/598134
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 7
    Online Resource
    Online Resource
    Investigation on the Effect of Hemodialysis Combined with MDT Multimode Intervention on Renal Fibrosis Degree and Renal Function Improvement in Uremia Patients
    Hindawi Limited ; 2022
    In:  Contrast Media & Molecular Imaging Vol. 2022 ( 2022-9-16), p. 1-7
    Details
    In: Contrast Media & Molecular Imaging, Hindawi Limited, Vol. 2022 ( 2022-9-16), p. 1-7
    Abstract: The effect of hemodialysis combined with MDT intervention on the degree of renal fibrosis and renal function in uremia patients was studied. 118 patients with uremia admitted to the hospital were selected as the research object, and they were divided into two groups according to the random number table method, 59 cases in the control group and 59 cases in the experimental group. The control group was treated with hemodialysis, and the experimental group was treated with MDT multimode intervention on the basis of hemodialysis. The differences in renal fibrosis, renal function, and satisfaction after treatment were compared before treatment and at 1, 3, and 6 months after treatment. The experimental results showed that hemodialysis combined with MDT multimode intervention in uremia patients could reduce renal fibrosis and improve renal function and improve clinical satisfaction evaluation.
    Type of Medium: Online Resource
    ISSN: 1555-4317 , 1555-4309
    URL: Article
    DOI: 10.1155/2022/1948092
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2222967-X
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  • 8
    Online Resource
    Online Resource
    Identification and Validation of a DNA Damage Repair-Related Signature for Diffuse Large B-Cell Lymphoma
    Hindawi Limited ; 2022
    In:  BioMed Research International Vol. 2022 ( 2022-10-14), p. 1-24
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-10-14), p. 1-24
    Abstract: Background. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin’s lymphoma in adults, whose prognostic scoring system remains to be improved. Dysfunction of DNA repair genes is closely associated with the development and prognosis of diffuse large B-cell lymphoma. The aim of this study was to establish and validate a DNA repair-related gene signature associated with the prognosis of DLBCL and to investigate the clinical predictive value of this signature. Methods. DLBCL cases were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. One hundred ninety-nine DNA repair-related gene sets were retrieved from the GeneCards database. The LASSO Cox regression was used to generate the DNA repair-related gene signature. Subsequently, the level of immune cell infiltration and the correlation between the gene signature and immune cells were analyzed using the CIBERSORT algorithm. Based on the Genomics of Drug Sensitivity in Cancer (GDSC) database, the relationship between the signature and drug sensitivity was analyzed, and together with the nomogram and gene set variation analysis (GSVA), the value of the signature for clinical application was evaluated. Results. A total of 14 DNA repair genes were screened out and included in the final risk model. Subgroup analysis of the training and validation cohorts showed that the risk model accurately predicted overall survival of DLBCL patients, with patients in the high-risk group having a worse prognosis than patients in the low-risk group. Subsequently, the risk score was confirmed as an independent prognostic factor by multivariate analysis. Furthermore, by CIBERSORT analysis, we discovered that immune cells, such as regulatory T cells (Tregs), activated memory CD4+ T cells, and gamma delta T cells showed significant differences between the high- and low-risk groups. In addition, we found some interesting associations of our signature with immune checkpoint genes (CD96, TGFBR1, and TIGIT). By analyzing drug sensitivity data in the GDSC database, we were able to identify potential therapeutics for DLBCL patients stratified according to our signature. Conclusions. Our study identified and validated a 14-DNA repair-related gene signature for stratification and prognostic prediction of DLBCL patients, which might guide clinical personalization of treatment.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2022/2645090
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
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  • 9
    Online Resource
    Online Resource
    Effects of ration level on growth, nitrogenous excretion and energy budget of juvenile yellow catfish, Pelteobagrus fulvidraco (Richardson) : Growth, nitrogenous excretion and energy budget of yellow catfish
    Hindawi Limited ; 2011
    In:  Aquaculture Research Vol. 42, No. 7 ( 2011-06), p. 899-905
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 42, No. 7 ( 2011-06), p. 899-905
    Type of Medium: Online Resource
    ISSN: 1355-557X
    URL: Issue
    URL: Article
    DOI: 10.1111/are.2011.42.issue-7
    DOI: 10.1111/j.1365-2109.2010.02626.x
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2011
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 10
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    Bacterial Colonization in the Airways and Intestines of Twin and Singleton Preterm Neonates: A Single-Center Study
    Hindawi Limited ; 2023
    In:  Canadian Journal of Infectious Diseases and Medical Microbiology Vol. 2023 ( 2023-8-1), p. 1-14
    Details
    In: Canadian Journal of Infectious Diseases and Medical Microbiology, Hindawi Limited, Vol. 2023 ( 2023-8-1), p. 1-14
    Abstract: Limited studies have investigated the microbial colonization of the airways and intestines in preterm neonates. We studied the composition of intestinal and airway bacterial colonies in several preterm twin pairs and singletons to explore the dominant bacteria, assess their variability, and predict their phenotypic and metabolic functions. In this descriptive study, we collected sputum and fetal stool specimens from 10 twin pairs (20 cases) and 20 singleton preterm neonates. These specimens were analyzed using 16S rRNA deep sequencing to study the alpha and beta diversities and community structures of airway and intestinal bacteria and predict their metabolic functions. Specimens from twins and singleton neonates had distinct aggregations of intestinal and airway bacteria but showed similarities and high microbial diversities during initial colonization. The top five phyla were Proteobacteria, Firmicutes, Actinobacteriota, Bacteroidota, and Cyanobacteria. The top ten genera were Streptococcus, Acinetobacter, Ralstonia, Staphylococcus, Comamonas, Enterococcus, Stenotrophomonas, Dechlorosoma, Sphingopyxis, and Rothia. Potentially pathogenic and highly stress-tolerant Gram-negative bacteria were predominant in the intestinal flora. A considerable proportion of colonies recovered from the airway and intestines of preterm neonates were functional bacteria. The richness of the intestinal and airway flora was not significantly different between twins and singletons, and the flora clustered together. Both intestinal and airway bacteria of twins and singletons were similar. The species involved in initial colonization were similar but different in proportions; therefore, changes in microbial structure and richness may not be attributed to these species.
    Type of Medium: Online Resource
    ISSN: 1918-1493 , 1712-9532
    URL: Article
    DOI: 10.1155/2023/2973605
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2207109-X
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