In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 3 ( 2023-3-7), p. e0281983-
Abstract:
Adverse events(AEs) related to hepatotoxicity have been reported in patients treated with immune checkpoint inhibitors (ICIs). As the number of adverse events increases, it is necessary to assess the differences in each immune checkpoint inhibitor regimen. The purpose of this study was to examine the relationship between ICIs and hepatotoxicity in a scientific and systematic manner. Data were obtained from the FDA Adverse Event Reporting System database (FAERS) and included data from the first quarter of 2014 to the fourth quarter of 2021. Disproportionality analysis assessed the association between drugs and adverse reactions based on the reporting odds ratio (ROR) and information components (IC). 9,806 liver adverse events were reported in the FAERS database. A strong signal was detected in older patients (≥65 years) associated with ICIs. hepatic adverse events were most frequently reported with Nivolumab (36.17%). Abnormal liver function, hepatitis, and autoimmune hepatitis were most frequently reported, and hepatitis and immune-mediated hepatitis signals were generated in all regimens. In clinical use, patients should be alert to these adverse effects, especially in elderly patients, who may be aggravated by the use of ICI.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0281983
DOI:
10.1371/journal.pone.0281983.g001
DOI:
10.1371/journal.pone.0281983.g002
DOI:
10.1371/journal.pone.0281983.g003
DOI:
10.1371/journal.pone.0281983.g004
DOI:
10.1371/journal.pone.0281983.t001
DOI:
10.1371/journal.pone.0281983.t002
DOI:
10.1371/journal.pone.0281983.t003
DOI:
10.1371/journal.pone.0281983.t004
DOI:
10.1371/journal.pone.0281983.t005
DOI:
10.1371/journal.pone.0281983.t006
DOI:
10.1371/journal.pone.0281983.s001
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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