In:
International Journal of Alzheimer's Disease, Hindawi Limited, Vol. 2011 ( 2011), p. 1-6
Abstract:
We measured cerebrospinal fluid (CSF) levels of the soluble isoforms of amyloid precursor protein (APP; sAPP α sAPP β ) and other CSF biomarkers in 107 patients with Alzheimer's disease (AD), dementia with Lewy body dementia (DLB), Parkinson's disease dementia (PDD), and normal controls (NC) using commercial kits. DLB and PDD were combined in a Lewy body dementia group (LBD). No differences were observed in sAPP α and sAPP β levels between the groups. Significant correlations were observed between sAPP α and sAPP β and between sAPP β and Mini-Mental State Examination scores in the total group analysis as well as when LBD and AD groups were analyzed separately. sAPP α and sAPP β levels correlated with A β 38, A β 40, A β 42, and Tau in the LBD group. In AD, sAPP α correlated with p-Tau and sAPP β with A β 40. The differential association between sAPP α and sAPP β with A β and Tau species between LBD and AD groups suggests a possible relationship with the underlying pathologies in LBD and AD.
Type of Medium:
Online Resource
ISSN:
2090-0252
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2011
detail.hit.zdb_id:
2573333-3
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