In:
Acta Paediatrica, Wiley, Vol. 108, No. 4 ( 2019-04), p. 645-653
Abstract:
We assessed the risk factors for transient acute kidney injury in very low birth weight ( VLBW ) infants treated for patent ductus arteriosus ( PDA ) using the serum creatinine‐based criteria in Kidney Disease: Improving Global Outcomes. Method This retrospective study of infants requiring ibuprofen and, or, surgery for haemodynamic relevant PDA s was performed at the University Children's Hospital of Saarland, Homburg, Germany, from January 2009 to December 2015. Results We studied 422 infants with a mean birth weight of 1059 ± 308.2 g. Acute kidney injuries developed in 150/295 infants (50.9%) with spontaneous PDA closure, in 46/82 (56.1%) who received intravenous ibuprofen treatment, in 18/24 (75.0%) who had surgery and in 15/21 infants (71.4%) who received both medical and surgical treatment. Acute kidney injuries were associated with birth weight and gestational age, Apgar scores at 10 minutes, the PDA size corrected for birth weight, a PDA with three affected circulatory territories, PDA surgery and gentamicin. Multiple logistic regression analysis showed particular associations between acute kidney injury and birth weight (p = 0.001), the 10‐minute Apgar score (p = 0.02) and gentamicin (p = 0.043). Conclusion Birth weight, the 10‐minute Apgar score and gentamicin were particularly associated with acute kidney injuries in our cohort.
Type of Medium:
Online Resource
ISSN:
0803-5253
,
1651-2227
DOI:
10.1111/apa.2019.108.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
1492629-5
detail.hit.zdb_id:
1501466-6
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