In:
Archives of Disease in Childhood - Fetal and Neonatal Edition, BMJ, Vol. 108, No. 5 ( 2023-09), p. 492-498
Kurzfassung:
To investigate whether extrauterine growth restriction (EUGR) during the neonatal hospitalisation by sex among extremely preterm (EPT) infants is associated with cerebral palsy (CP) and cognitive and motor abilities at 5 years of age. Study design Population-based cohort of births 〈 28 weeks of gestation with data from obstetric and neonatal records and parental questionnaires and clinical assessments at 5 years of age. Setting 11 European countries. Patients 957 EPT infants born in 2011–2012. Main outcomes EUGR at discharge from the neonatal unit was defined as (1) the difference between Z-scores at birth and discharge with 〈 −2 SD as severe, −2 to −1 SD as moderate using Fenton’s growth charts (Fenton) and (2) average weight-gain velocity using Patel’s formula in grams (g) per kilogram per day (Patel) with 〈 11.2 g (first quartile) as severe, 11.2–12.5 g (median) as moderate. Five-year outcomes were: a CP diagnosis, intelligence quotient (IQ) using the Wechsler Preschool and Primary Scales of Intelligence tests and motor function using the Movement Assessment Battery for Children, second edition. Results 40.1% and 33.9% children were classified as having moderate and severe EUGR, respectively, by Fenton and 23.8% and 26.3% by Patel. Among children without CP, those with severe EUGR had lower IQ than children without EUGR (−3.9 points, 95% Confidence Interval (CI)=−7.2 to −0.6 for Fenton and −5.0 points, 95% CI=−8.2 to −1.8 for Patel), with no interaction by sex. No significant associations were observed between motor function and CP. Conclusions Severe EUGR among EPT infants was associated with decreased IQ at 5 years of age.
Materialart:
Online-Ressource
ISSN:
1359-2998
,
1468-2052
DOI:
10.1136/archdischild-2022-324988
Sprache:
Englisch
Verlag:
BMJ
Publikationsdatum:
2023
ZDB Id:
2188490-0
Permalink
