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  • 1
    Online Resource
    Online Resource
    Effects of cardiovascular drugs on TSH serum levels in patients on replacement therapy after thyroidectomy
    Dustri-Verlgag Dr. Karl Feistle ; 2016
    In:  Int. Journal of Clinical Pharmacology and Therapeutics Vol. 54, No. 08 ( 2016-08-01), p. 628-633
    Details
    In: Int. Journal of Clinical Pharmacology and Therapeutics, Dustri-Verlgag Dr. Karl Feistle, Vol. 54, No. 08 ( 2016-08-01), p. 628-633
    Type of Medium: Online Resource
    ISSN: 0946-1965
    URL: Article
    DOI: 10.5414/CP202606
    Language: English
    Publisher: Dustri-Verlgag Dr. Karl Feistle
    Publication Date: 2016
    SSG: 12
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Enhanced cytotoxicity and apoptosis by raloxifene in combination with estrogen and methotrexate in human endometrial stromal cells
    Wiley ; 2018
    In:  Chemical Biology & Drug Design Vol. 91, No. 4 ( 2018-04), p. 885-892
    Details
    In: Chemical Biology & Drug Design, Wiley, Vol. 91, No. 4 ( 2018-04), p. 885-892
    Abstract: Endometrial hyperplasia is a condition that may lead to the development of endometrial carcinoma. Initially, changes of the endometrium are caused by the estrogen's hyperstimulation that may lead to the development of an irregular bleeding and the infertility problems. Therapy of endometrial hyperplasia is limited to medical and surgical approaches. During the past decade, the new types of drugs were developed for the treatment of the endometrial hyperplasia. Here, for the first time, we investigated the cytotoxic effects of the various combinations of estrogen, raloxifene, and methotrexate in human ThESC cell line as a possible potential treatment of the endometrial hyperplasia. Our aim was to investigate and to determine the most efficient combination of investigated drugs in ThESC cells during 24‐hr period using MTT assay, FACS analysis, and immunofluorescence staining. Our results demonstrated that the combination of raloxifene with methotrexate efficiently induced both the cytotoxicity and apoptosis in ThESC cells when compared to their single effect, as well as to the effect of combined treatment of raloxifene with estrogen. The application of the low doses of methotrexate combined with raloxifene offers all advantages of a potential beneficial antitumor match in cancer chemoprevention and therapy.
    Type of Medium: Online Resource
    ISSN: 1747-0277 , 1747-0285
    URL: Issue
    URL: Article
    DOI: 10.1111/cbdd.2018.91.issue-4
    DOI: 10.1111/cbdd.13152
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2216600-2
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Impact of aromaticity on anticancer activity of polypyridyl ruthenium(II) complexes: synthesis, structure, DNA/protein binding, lipophilicity and anticancer activity
    Springer Science and Business Media LLC ; 2017
    In:  JBIC Journal of Biological Inorganic Chemistry Vol. 22, No. 7 ( 2017-10), p. 1007-1028
    Details
    In: JBIC Journal of Biological Inorganic Chemistry, Springer Science and Business Media LLC, Vol. 22, No. 7 ( 2017-10), p. 1007-1028
    Type of Medium: Online Resource
    ISSN: 0949-8257 , 1432-1327
    URL: Article
    DOI: 10.1007/s00775-017-1479-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 1464026-0
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Antitumor activity of ruthenium(II) complexes on HCT 116 cell line in vitro
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2022
    In:  Education and Research in Health Sciences Vol. 1, No. 1 ( 2022), p. 6-12
    Details
    In: Education and Research in Health Sciences, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 1, No. 1 ( 2022), p. 6-12
    Abstract: In the field of non-platinum complexes, ruthenium complexes have shown very strong antitumor activity on various types of cisplatin-resistant tumors. In addition, Ru(II) and Ru(III) complexes have shown a high degree of selectivity towards cancer cells as well as antimetastatic effects. Importantly, ruthenium compounds can bind to the DNA molecule of a tumor cell and thus reduce the viability of cancer cells. Moreover, ruthenium complexes can bind to human serum albumin and transferrin, which makes their transfer to tumor cells more efficient than platinum compounds. Consequently, the research aim was to investigate the antitumor effect of two synthesized Ru(II) complexes [Ru(Cl-Ph-tpy)(phen)Cl]Cl (K1) and [Ru(Cl-Ph-tpy)(o-bqdi)Cl] Cl (K2) on the HCT 116 cell line, and to define the mechanism of cell death that these compounds induce in HCT 116 cancer cells. Results of our research clearly showed that the two investigated ruthenium complexes K1 and K2 showed very strong antitumor activity against the HCT 116 tumor cell line. Additionally, ruthenium complex K1 showed higher antitumor activity than ruthenium K2 complex and cisplatin after 72 hours of treatment. Our findings demonstrated that both K1 and K2 ruthenium compounds exhibited strong antitumor activity against HCT 116 cell line by induction of early apoptosis.
    Type of Medium: Online Resource
    ISSN: 2956-0640 , 2956-0640
    Uniform Title: Antitumorska aktivnost rutenijum (II) kompleksa na HCT 116 ćelije in vitro
    URL: Article
    DOI: 10.5937/erhs2201006Z
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    Teucrium polium induces apoptosis in peripheral blood lymphocytes isolated from human chronic lymphocytic leukemia
    National Library of Serbia ; 2020
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 77, No. 12 ( 2020), p. 1252-1259
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 77, No. 12 ( 2020), p. 1252-1259
    Abstract: Background/Aim. Chronic lymhocytic leukemia (CLL) is considered more as a disease of cells accumulation due to the defect in apoptosis rather than deregulated cell?s proliferation. The activation of apoptosis is one of the main molecular mechanisms responsible for anti-cancer activities of most of the currently studied potential anti-cancer agents, including natural compounds. Teucrium polium (TP) extracts exhibited strong cytotoxic effects in murine leukemia cell line, RAW 264.7 and human melanoma cell line, C32, but their cytotoxic effects against human leukemia cells were unknown. Methods. The viability of human leukemia cell lines (MOLT 4 and JVM 13), lymphocytes isolated from 28 patients with CLL (CLL cells), and peripheral blood mononuclear cells (PBMCs) isolated from 16 healthy subjects treated with TP leaves methanolic extract, was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis of TP treated CLL cells was measured by flow cytometry applying Annexin V/7AAD staining. The expressions of active proapoptotic protein Bax, antiapoptotic protein Bcl-2, cytochrome c and the percentage of cells containing cleaved caspase-3 in treated CLL cells was determined by flow cytometry and immunocytochemistry. Results. The TP meth-anolic extract decreased the viability of all tested human leukemia cells but it had no effect on the viability of PBMCs isolated from healthy subjects. The cytotoxic effect of TP was caused by its induction of CLL cells? apoptosis. TP disarranged the ratio of the expressions of proapoptotic Bax and antiapoptotic Bcl-2 protein in favor of Bax, consequently inducing apoptosis by cytochrome c mitochondrial release and activation of caspase-3 in treated CLL cells. Conclusion. The TP leaves methanolic induced selective apoptosis in CLL cells and it affected the expressions of key proteins involved in the regulation of programmed cell death.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP181010005Z
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2020
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Antitumor Effect of the Chalcone Analogue, (E) -1-(4-Ethoxy-3-Methoxyphenyl) -5- Methylhex-1-En-3-One on HeLa Cell Line
    Walter de Gruyter GmbH ; 2019
    In:  Serbian Journal of Experimental and Clinical Research Vol. 20, No. 3 ( 2019-09-01), p. 215-221
    Details
    In: Serbian Journal of Experimental and Clinical Research, Walter de Gruyter GmbH, Vol. 20, No. 3 ( 2019-09-01), p. 215-221
    Abstract: Chalcones represent precursor compounds for flavonoids biosynthesis in plants. Chalcones, 1,3-diaryl-2-propen-1-ones, have unique chemical structure with conjugated double bonds and delocalized π-electron system on both aromatic rings. Various studies have shown that chemical structure of chalcone is responsible for their antitumor effect. In our study, we have examined the antitumor effect of chalcone analogue (E) -1- (4-ethoxy-3-methoxyphenyl) -5-methylhex-1-en-3-one (CH) on HeLa cells. The antitumor efficiency of different CH concentrations was compared to the antitumor effects of dehydrozingerone and cisplatin. The viability of the cells was evaluated using MTT assay; type of the cell death was evaluated by Annexin V-FITC/7-AAD staining using FACS analysis; morphology changes of treated cells were visualized and compared to untreated cells using phase contrast microscopy. The result of our research showed that CH have a stronger antitumor compared to the effect both of dehydrozingerone and cisplatin. Our results indicated that chalcone analogue induced cell death via activation of apoptosis more powerfully compared to the apoptosis induced with dehydrozingerone and cisplatin.
    Type of Medium: Online Resource
    ISSN: 2335-075X , 1820-8665
    URL: Article
    DOI: 10.2478/sjecr-2018-0048
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2019
    detail.hit.zdb_id: 2710266-X
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  • 7
    Online Resource
    Online Resource
    Older Hypertensive Patients’ Adherence to Healthy Lifestyle Behaviors
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2018
    In:  Serbian Journal of Experimental and Clinical Research Vol. 19, No. 1 ( 2018-3-1), p. 51-56
    Details
    In: Serbian Journal of Experimental and Clinical Research, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 19, No. 1 ( 2018-3-1), p. 51-56
    Abstract: Non-pharmacological treatment including diet, body weight reduction, smoking cessation and physical activity, is very important part of hypertension treatment. The objective of this study was to investigate the adherence to healthy lifestyle behavior in the representative sample of the older hypertensive patients, and to investigate factors associated with adherence in the studied older population. The study was conducted on random sample of 362 long term hypertensive ( 〉 five years) patients older than 65 years of age, at Health Care Center of Kragujevac. Adherence was assessed using the structured questionnaire for the analysis of the implementation of both hypertension and diabetes guidelines in the primary care. Both bivariate and multivariate analyses were conducted. Nearly 35% of examined patients were highly adherent; they exercised regularly, avoided smoking for at least five years and consumed special healthy diet prescribed for hypertension. Another 35.6% of the cases reported exercising regularly, 39.5% followed the recommended diet for the hypertension, while 23.4% of the patients have still consumed cigarettes. Multivariate logistic regression demonstrated that received counseling on healthy lifestyle behaviors by physicians and lack of education predicted high adherence to healthy lifestyle behavior. In order to improve adherence of elderly hypertensive patients to healthy lifestyle, strengthening patient-physician relationships through efforts to enhance communication may be a promising strategy to enhance patients’ engagement in healthy lifestyle behaviors for hypertension. Such an improvement could be achieved through the education of both the physicians and patients.
    Type of Medium: Online Resource
    ISSN: 2335-075X , 1820-8665
    URL: Article
    DOI: 10.1515/sjecr-2016-0083
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2018
    detail.hit.zdb_id: 2710266-X
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  • 8
    Online Resource
    Online Resource
    Ligustrum vulgare leaves and fruit extracts induce apoptosis of human leukemia cells
    Hrvatski Prirodoslovno Drustvo (Croatian Society for Natural Sciences) ; 2022
    In:  Periodicum Biologorum Vol. 123, No. 3-4 ( 2022-07-01), p. 71-77
    Details
    In: Periodicum Biologorum, Hrvatski Prirodoslovno Drustvo (Croatian Society for Natural Sciences), Vol. 123, No. 3-4 ( 2022-07-01), p. 71-77
    Abstract: Background and purpose: Cytotoxic effects of Ligustrum vulgare leaves on HeLa cervical tumor cells suggested that Ligustrum vulgare extracts should be investigated as potential anticancer agents. Therefore, we examined a potential antileukemic activity of methanolic extracts of Ligustrum vulgare leaves and fruit extracts on two types of leukemia cells, MOLT-4 and JVM-13, lymphocytes isolated from the blood of 33 chronic lymphocytic leukemia (CLL) patients and on mononuclear leukocytes isolated from the blood of 18 healthy individuals.Material and methods: The cytotoxicity of examined extracts was measured by MTT assay and LDH activity test. The antiapoptotic potential of tested extracts was measured by Annexin V/7AAD flowcytometric assay.Results: The results showed that both extracts exhibited a moderate cytotoxic effect on all three types of leukemia cells. The Ligustrum vulgare leaf extract was the most effective on MOLT-4 cells, the fruit extract on JVM-13 cells and both extracts were equally effective on CLL cells. In addition, none of the tested extracts was toxic to healthy mononuclear cells. Both extracts acted by inducing apoptosis of leukemic cells.Conclusion: Ligustrum vulgare extracts exhibit significant antileukemic potential and should be further investigated.
    Type of Medium: Online Resource
    ISSN: 1849-0964 , 0031-5362
    URL: Article
    DOI: 10.18054/pb.v123i3-4.19206
    Language: Unknown
    Publisher: Hrvatski Prirodoslovno Drustvo (Croatian Society for Natural Sciences)
    Publication Date: 2022
    detail.hit.zdb_id: 2493383-1
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Induction of mitochondrial apoptotic pathway by raloxifene and estrogen in human endometrial stromal ThESC cell line
    Termedia Sp. z.o.o. ; 2017
    In:  Archives of Medical Science Vol. 2 ( 2017), p. 293-301
    Details
    In: Archives of Medical Science, Termedia Sp. z.o.o., Vol. 2 ( 2017), p. 293-301
    Type of Medium: Online Resource
    ISSN: 1734-1922
    URL: Article
    DOI: 10.5114/aoms.2016.59874
    Language: Unknown
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2017
    detail.hit.zdb_id: 2203781-0
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