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  • Yuan, Yongsheng  (6)
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  • 1
    Online Resource
    Online Resource
    Impaired structural and reserved functional topological organizations of brain networks in Parkinson’s disease with freezing of gait
    AME Publishing Company ; 2023
    In:  Quantitative Imaging in Medicine and Surgery Vol. 13, No. 1 ( 2023-1), p. 66-79
    Details
    In: Quantitative Imaging in Medicine and Surgery, AME Publishing Company, Vol. 13, No. 1 ( 2023-1), p. 66-79
    Type of Medium: Online Resource
    ISSN: 2223-4292 , 2223-4306
    URL: Journal
    URL: Article
    DOI: 10.21037/qims
    DOI: 10.21037/qims-22-351
    Language: Unknown
    Publisher: AME Publishing Company
    Publication Date: 2023
    detail.hit.zdb_id: 2653586-5
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  • 2
    Online Resource
    Online Resource
    Cholinergic basal forebrain atrophy in Parkinson's disease with freezing of gait
    Wiley ; 2023
    In:  Annals of Clinical and Translational Neurology Vol. 10, No. 5 ( 2023-05), p. 814-824
    Details
    In: Annals of Clinical and Translational Neurology, Wiley, Vol. 10, No. 5 ( 2023-05), p. 814-824
    Abstract: Mounting research support that cholinergic dysfunction plays a prominent role in freezing of gait (FOG), which commonly occurs in Parkinson's disease (PD). Basal forebrain (BF), especially the cholinergic nuclei 4 (Ch4), provides the primary source of the brain cholinergic input. However, whether the degeneration of BF and its innervated cortex contribute to the pathogenesis of FOG is unknown. Objective To explore the role of structural alterations of BF and its innervated cortical brain regions in the pathogenesis of PD patients with freezing. Methods Magnetic resonance imaging assessments and neurological assessments were performed on 20 PD patients with FOG (PD‐FOG), 20 without FOG (PD‐NFOG), and 21 healthy participants. Subregion volumes of the BF were compared among groups. Local gyrification index (LGI) was computed to reveal the cortical alternations. Relationships among subregional BF volumes, LGI, and the severity of FOG were evaluated by multiple linear regression. Results Our study discovered that, compared to PD‐NFOG, PD‐FOG exhibited significant Ch4 atrophy ( p  = 4.6 × 10 −5 ), accompanied by decreased LGI values in the left entorhinal cortex ( p  = 3.00 × 10 −5 ) and parahippocampal gyrus ( p  = 2.90 × 10 −5 ). Based on the regression analysis, Ch4 volume was negatively associated with FOG severity in PD‐FOG group ( β  = −12.224, T = −2.556, p  = 0.031). Interpretation Our results imply that Ch4 degeneration and microstructural disorganization of its innervated cortical brain regions may play important roles in PD‐FOG.
    Type of Medium: Online Resource
    ISSN: 2328-9503 , 2328-9503
    URL: Issue
    URL: Article
    DOI: 10.1002/acn3.v10.5
    DOI: 10.1002/acn3.51769
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2740696-9
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  • 3
    Online Resource
    Online Resource
    Cortical Disinhibition Drives Freezing of Gait in Parkinson's Disease and an Exploratory Repetitive Transcranial Magnetic Stimulation Study
    Wiley ; 2023
    In:  Movement Disorders
    Details
    In: Movement Disorders, Wiley
    Abstract: Dysfunction of the primary motor cortex, participating in regulation of posture and gait, is implicated in freezing of gait (FOG) in Parkinson's disease (PD). Objective The aim was to reveal the mechanisms of “OFF‐period” FOG (OFF‐FOG) and “levodopa‐unresponsive” FOG (ONOFF‐FOG) in PD. Methods We measured the transcranial magnetic stimulation (TMS) indicators and gait parameters in 21 healthy controls (HCs), 15 PD patients with ONOFF‐FOG, 15 PD patients with OFF‐FOG, and 15 PD patients without FOG (Non‐FOG) in “ON” and “OFF” medication conditions. Difference of TMS indicators in the four groups and two conditions and its correlations with gait parameters were explored. Additionally, we explored the effect of 10 Hz repetitive TMS on gait and TMS indicators in ONOFF‐FOG patients. Results In “OFF” condition, short interval intracortical inhibition (SICI) exhibited remarkable attenuation in FOG patients (both ONOFF‐FOG and OFF‐FOG) compared to Non‐FOG patients and HCs. The weakening of SICI correlated with impaired gait characteristics in FOG. However, in “ON” condition, SICI in ONOFF‐FOG patients reduced compared to OFF‐FOG patients. Pharmacological treatment significantly improved SICI and gait in OFF‐FOG patients, and high‐frequency repetitive TMS distinctly improved gait in ONOFF‐FOG patients, accompanied by enhanced SICI. Conclusions Motor cortex disinhibition, represented by decreased SICI, is related to FOG in PD. Refractory freezing in ONOFF‐FOG patients correlated with the their reduced SICI insensitive to dopaminergic medication. SICI can serve as an indicator of the severity of impaired gait characteristics in FOG and reflect treatments efficacy for FOG in PD patients. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Article
    DOI: 10.1002/mds.29595
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2041249-6
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  • 4
    Online Resource
    Online Resource
    Table_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Aging Neuroscience Vol. 14 ( 2022-8-2)
    Details
    In: Frontiers in Aging Neuroscience, Frontiers Media SA, Vol. 14 ( 2022-8-2)
    Abstract: The cerebellum is associated with the emergence of levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD), yet the neural mechanism remains obscure. Our aim was to ascertain the role of functional connectivity (FC) patterns of the cerebellar dentate nucleus (DN) in the pathogenesis of peak-dose dyskinesia in PD. Twenty-three peak-dose dyskinetic PD patients, 27 non-dyskinetic PD patients, and 36 healthy controls (HCs) were enrolled and underwent T1-weighted and resting-state functional magnetic resonance imaging (rs-fMRI) scans after dopaminergic medication intake. We selected left and right DN as the regions of interest and then employed voxel-wise FC analysis and voxel-based morphometry analysis (VBM). The correlations between the altered FC pattern and clinical scores were also examined. Finally, receiver operating characteristic (ROC) curve analysis was performed to assess the potential of DN FC measures as a feature of peak-dose dyskinesia in PD. Dyskinetic PD patients showed excessively increased FC between the left DN and right putamen compared with the non-dyskinetic. When compared with controls, dyskinetic PD patients mainly exhibited increased FC between left DN and bilateral putamen, left paracentral lobule, right postcentral gyrus, and supplementary motor area. Additionally, non-dyskinetic PD patients displayed increased FC between left DN and left precentral gyrus and right paracentral lobule compared with controls. Meanwhile, increased FC between DN (left/right) and ipsilateral cerebellum lobule VIII was observed in both PD subgroups. However, no corresponding alteration in gray matter volume (GMV) was found. Further, a positive correlation between the z -FC values of left DN-right putamen and the Unified Dyskinesia Rating Scale (UDysRS) was confirmed in dyskinetic PD patients. Notably, ROC curve analyses revealed that the z -FC values of left DN-right putamen could be a potential neuroimaging feature identifying dyskinetic PD patients. Our findings demonstrated that the excessively strengthened connectivity of DN-putamen might contribute to the pathophysiological mechanisms of peak-dose dyskinesia in PD.
    Type of Medium: Online Resource
    ISSN: 1663-4365
    URL: Article
    URL: Article
    DOI: 10.3389/fnagi.2022.943179
    DOI: 10.3389/fnagi.2022.943179.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2558898-9
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  • 5
    Online Resource
    Online Resource
    Dynamic functional connectivity reveals hyper-connected pattern and abnormal variability in freezing of gait of Parkinson's disease
    Elsevier BV ; 2023
    In:  Neurobiology of Disease Vol. 185 ( 2023-09), p. 106265-
    Details
    In: Neurobiology of Disease, Elsevier BV, Vol. 185 ( 2023-09), p. 106265-
    Type of Medium: Online Resource
    ISSN: 0969-9961
    URL: Article
    DOI: 10.1016/j.nbd.2023.106265
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1471408-5
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Reduced Short-Latency Afferent Inhibition in Parkinson’s Disease Patients with L-dopa-Unresponsive Freezing of Gait
    IOS Press ; 2022
    In:  Journal of Parkinson's Disease Vol. 12, No. 8 ( 2022-12-16), p. 2507-2518
    Details
    In: Journal of Parkinson's Disease, IOS Press, Vol. 12, No. 8 ( 2022-12-16), p. 2507-2518
    Abstract: Background: Freezing of gait (FOG) in Parkinson’s disease (PD), especially the “L-dopa-unresponsive” subtype, is associated with the dysfunction of non-dopaminergic circuits. Objective: We sought to determine whether cortical sensorimotor inhibition evaluated by short-latency afferent inhibition (SAI) related to cholinergic and gamma-aminobutyric acid (GABA)-ergic activities is impaired in PD patients with L-dopa-unresponsive FOG (ONOFF-FOG). Methods: SAI protocol was performed in 28 PD patients with ONOFF-FOG, 15 PD patients with “off” FOG (OFF-FOG), and 25 PD patients without FOG during medication “on” state. Additionally, 10 ONOFF-FOG patients underwent SAI testing during both “off” and “on” states. Twenty healthy controls participated in this study. Gait was measured objectively using a portable Inertial Measurement Unit system, and participants performed 5-meter Timed Up and Go single- and dual-task conditions. Spatiotemporal gait characteristics and their variability were determined. FOG manifestations and cognition were assessed with clinical scales. Results: Compared to controls, PD patients without FOG and with OFF-FOG, ONOFF-FOG PD patients showed significantly reduced SAI. Further, dopaminergic therapy had no remarkable effect on this SAI alterations in ONOFF-FOG. Meanwhile, OFF-FOG patients presented decreased SAI only relative to controls. PD patients with ONOFF-FOG exhibited decreased gait speed, stride length, and increased gait variability relative to PD patients without FOG and controls under both walking conditions. For ONOFF-FOG patients, significant associations were found between SAI and FOG severity, gait characteristics and variability. Conclusion: Reduced SAI was associated with severe FOG manifestations, impaired gait characteristics and variability in PD patients with ONOFF-FOG, suggesting the impaired thalamocortical cholinergic-GABAergic SAI pathways underlying ONOFF-FOG.
    Type of Medium: Online Resource
    ISSN: 1877-7171 , 1877-718X
    URL: Article
    DOI: 10.3233/JPD-223498
    Language: Unknown
    Publisher: IOS Press
    Publication Date: 2022
    detail.hit.zdb_id: 2599550-9
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