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  • SAGE Publications  (16)
  • Yu, Bin  (16)
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  • SAGE Publications  (16)
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  • 1
    Online Resource
    Online Resource
    Preliminary proteomic-based identification of a novel protein for Down's syndrome in maternal serum
    SAGE Publications ; 2012
    In:  Experimental Biology and Medicine Vol. 237, No. 5 ( 2012-05), p. 530-539
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 237, No. 5 ( 2012-05), p. 530-539
    Abstract: Prenatal screening for Down's syndrome (DS) is in need of improvement. As a powerful platform, proteomics techniques could also be used for identification of new biomarkers for DS screening. In this case-control proteome study, pregnant women were diagnosed prenatally by karyotype analysis from amniotic fluid (AF). Maternal serum samples were collected from six pregnancies with fetuses affected by DS and six pregnancies with normal fetuses. First, we used two-dimensional electrophoresis and mass spectrometry to identify the different levels of expression of proteins in maternal serum between the DS and control groups in the second trimester. Second, we used bioinformatics to analyze the proteins by DAVID. Then, the interesting candidates were further tested by enzyme-linked immunosorbent assay (ELISA). Twenty-nine proteins were successfully identified in maternal serum obtained from pregnancies with fetuses affected by DS. The top five proteins up-regulated were serotransferrin (TF), alpha-1b-glycoprotein (A1BG), desmin (DES), alpha-1-antitrypsin (SERPINA1) and ceruloplasmin (CP), while serum amyloid P-component (APCS) was the most down-regulated protein. These 29 proteins were categorized based on binding, catalytic activity and enzyme regulator activity. The biological roles were involved in biological regulation, metabolic processes, cellular processes and response to a stimulus. Based on ELISA, the median concentrations of CP and complement factor B (CFB) were 332.3 and 412.3 ng/mL, respectively. The concentrations of CP and CFB were significantly higher in the DS group than in the control group ( P 〈 0.05). In conclusion, proteomic approaches offer the possibility of further improving the performance of DS screening and our identification of up- and down-regulated proteins may lead to new candidates for DS screening.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1258/ebm.2012.011312
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Arthroscopic-assisted percutaneous fixation of intra-articular calcaneal fractures using an intraoperative distraction device
    SAGE Publications ; 2021
    In:  Journal of Orthopaedic Surgery Vol. 29, No. 1 ( 2021-01-01), p. 230949902097909-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 29, No. 1 ( 2021-01-01), p. 230949902097909-
    Abstract: To evaluate the quality of reduction and clinical outcomes by using Percutaneous Distractor and Subtalar Arthroscopy Closed Reduction followed by Internal Fixation (PDSA-CRIF) in the intra-articular calcaneal fracture. Methods: A consecutive case series of 453 patients with 507 displaced intra-articular calcaneal fractures was recruited in this retrospective study. We performed PDSA-CRIF to treat intra-articular calcaneal fractures. The quality of reduction was assessed by early postoperative Computed Tomography (CT) scans and measurement of serial Bohler’s angles during follow-ups. Clinical outcomes were evaluated by Visual Analogue Scale (VAS) and the American Foot & Ankle Society ankle-hind foot scale (AOFAS) scoring system. Results: Fifty-nine patients (68 fractures) who had complete clinical data and follow-up of at least 12-months (mean: 14 months, range: 12–59 months) were finally included. Anatomical and near-anatomical reduction in subtalar articular surface which had less than 2 mm gap or step-off was found in 93% fractures. Unsatisfactory reduction was found in 7%. Conclusion: Arthroscopic-assisted percutaneous fixation using a distraction device is effective in achieving positive short-term results in the displaced intra-articular calcaneal fractures. A multicenter, large sample, randomized control trial is needed to fully evaluate the long-term effects of PDSA-CRIF in comparison to other methods.
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499020979095
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2128854-9
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  • 3
    Online Resource
    Online Resource
    Optimization and testing of suspension system of electric mini off-road vehicles
    SAGE Publications ; 2020
    In:  Science Progress Vol. 103, No. 1 ( 2020-01), p. 003685041988187-
    Details
    In: Science Progress, SAGE Publications, Vol. 103, No. 1 ( 2020-01), p. 003685041988187-
    Abstract: Mini vehicles with a small wheelbase are extremely sensitive to road roughness. The aim of this study is to explore the influence of road information on ride comfort and enhance the ride comfort of mini vehicles. According to the 5-degree-of-freedom vibration model of an electric mini off-road vehicle, the partial differential matrix equation of system motion is established using the Lagrange method, and the frequency response characteristic of the system is analyzed. The input matrix of pavement unevenness is obtained by considering the mutual power spectrum density between front and rear wheels. Road surface roughness information is obtained using an instrument for measuring road roughness. A comprehensive objective function and a constraint condition are established for comfort and safety. Based on the parameters obtained through the optimum design of a 1/4 vehicle model, the optimized stiffness and damping coefficient of suspension are obtained using a MATLAB optimization program. The law of the vibration performance of off-road vehicles with respect to suspension stiffness and the damping coefficient is obtained through the analysis of optimized results. A driving simulation and a test are conducted on the electric mini off-road vehicle. The results show that the use of the measured pavement data as simulation input is closer to the actual situation and provides higher accuracy compared to the simulated pavement model. According to the optimization and test results, the parameters optimized by a 1/2 vehicle (5 degrees of freedom) vibration model are better than those optimized by the 1/4 vehicle vibration model. The optimization results confirm reduction in acceleration, acceleration power spectrum density, and the root mean square of the weighted acceleration of the seat. This shows that the electric mini off-road vehicle provides better ride comfortability after optimization.
    Type of Medium: Online Resource
    ISSN: 0036-8504 , 2047-7163
    URL: Article
    DOI: 10.1177/0036850419881872
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2483680-1
    detail.hit.zdb_id: 2199376-2
    SSG: 11
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  • 4
    Online Resource
    Online Resource
    Investigation of the suspension design and ride comfort of an electric mini off-road vehicle
    SAGE Publications ; 2019
    In:  Advances in Mechanical Engineering Vol. 11, No. 1 ( 2019-01), p. 168781401882335-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 11, No. 1 ( 2019-01), p. 168781401882335-
    Abstract: In view of the little research that has been conducted on the ride comfort of mini vehicles, an electric mini off-road vehicle was designed in this study and a 2 degree-of-freedom quarter car model was established to investigate the ride comfortability. The amplitude-frequency and vibration response characteristics of the suspension were analyzed with the natural frequencies of the front and rear suspensions selected in accordance with the required driving performance. A comprehensive objective function with respect to the safety and comfortability was established, and the damping ratio of the suspension was determined. The damping characteristics of the shock absorber were analyzed to derive an adjustment rule of the suspension damping ratio. The piecewise linear speed characteristics of the shock absorber were subsequently obtained, and suspension-parameter identification and ride comfort tests were conducted. The test results showed that the natural frequencies and damping ratios of the front and rear suspensions were 1.676 and 1.922 Hz, and 0.225 and 0.242, respectively. The results of a pulse input test and D-level road random running test also demonstrated the safety and good ride comfortability of the vehicle.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814018823351
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2501620-9
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  • 5
    Online Resource
    Online Resource
    The influence of drawing pressure on the properties of PET/PA6 bicomponent spunbonded fibers
    SAGE Publications ; 2017
    In:  Journal of Industrial Textiles Vol. 46, No. 5 ( 2017-01), p. 1281-1293
    Details
    In: Journal of Industrial Textiles, SAGE Publications, Vol. 46, No. 5 ( 2017-01), p. 1281-1293
    Abstract: The properties of fibers were significantly affected by drawing during the spunbond process. In this paper, the influence of drawing pressure on the properties of spunbonded PET/PA6 hollow pie wedge bicomponent filaments was studied, and their performance was characterized by differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, Beion F6 fiber fineness tester, and single fiber strength tester. The hollow pie wedge bicomponent fiber had a distinct interface between the two polymers due to poor compatibility. With increasing of drawing pressure, diameter of the fibers reduced regularly. When the drawing pressure increased, both the degree of crystallinity and orientation of bicomponent fibers enhanced, and the melting point of polyester component increased as well. Furthermore, with increasing of drawing pressure, the breaking strength of the fibers increased, but the breaking elongation and linear density decreased.
    Type of Medium: Online Resource
    ISSN: 1528-0837 , 1530-8057
    URL: Article
    DOI: 10.1177/1528083715627162
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2095351-3
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  • 6
    Online Resource
    Online Resource
    Manual preoperative tracheal retraction exercise decreases the occurrence of postoperative oropharyngeal dysphagia after anterior cervical discectomy and fusion
    SAGE Publications ; 2017
    In:  Journal of Orthopaedic Surgery Vol. 25, No. 3 ( 2017-09), p. 230949901773144-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 25, No. 3 ( 2017-09), p. 230949901773144-
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499017731446
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2128854-9
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  • 7
    Online Resource
    Online Resource
    Carboxymethyl chitosan–zinc coating for prevention of pin tract infection: An animal model
    SAGE Publications ; 2018
    In:  Journal of Orthopaedic Surgery Vol. 26, No. 1 ( 2018-01), p. 230949901774998-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 26, No. 1 ( 2018-01), p. 230949901774998-
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499017749981
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2128854-9
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  • 8
    Online Resource
    Online Resource
    A reformative shear precipitation procedure for the fabrication of vancomycin-loaded poly(lactide-co-glycolide) microspheres
    SAGE Publications ; 2017
    In:  Journal of Biomaterials Applications Vol. 31, No. 7 ( 2017-02), p. 995-1009
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 31, No. 7 ( 2017-02), p. 995-1009
    Abstract: This study reports the encapsulation of vancomycin, as a model hydrophilic drug, into poly(lactide-co-glycolide) microspheres using a novel reformative shear precipitation procedure. In contrast to the external aqueous phase used in the conventional microencapsulation technique based on emulsion solvent evaporation/extraction, the reformative shear precipitation procedure explored in this study uses a shear medium composed of glycerol as the viscous medium and ethanol as polymer antisolvent, which is relatively immiscible with the hydrophilic drug. This limits drug diffusion and leads to rapid microsphere solidification, which allows a large proportion of the hydrophilic drug to be encapsulated within the microspheres. The influence of various processing parameters, including polymer concentration, volume ratio of ethanol to glycerol in the shear medium, volume of aqueous drug solution, initial drug loading, and injecting rate of the drug–polymer emulsion, on the encapsulation efficiency and characteristics of resulting microspheres were investigated. The morphology and release characteristics, as well as mechanical, in vitro and in vivo behaviour of vancomycin-loaded poly(lactide-co-glycolide) microspheres prepared using the novel procedure were also investigated. The results demonstrated that the reformative shear precipitation procedure could achieve the loading of hydrophilic drugs into poly(lactide-co-glycolide) microspheres with high encapsulation efficiency, and the success of the procedure was largely influenced by the volume ratio of ethanol to glycerol in the shear medium. Vancomycin-loaded poly(lactide-co-glycolide) microspheres prepared using this procedure demonstrated favourable mechanical characteristics, antibacterial activity, and in vivo degradation behaviour which suggested their suitability for use as a sustained delivery system.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328216689199
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Cerium-containing α-calcium sulfate hemihydrate bone substitute promotes osteogenesis
    SAGE Publications ; 2019
    In:  Journal of Biomaterials Applications Vol. 34, No. 2 ( 2019-08), p. 250-260
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 34, No. 2 ( 2019-08), p. 250-260
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328219849712
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Study on dual-monomer melt-grafted poly(lactic acid) compatibilized poly(lactic acid)/polyamide 11 blends and toughened melt-blown nonwovens
    SAGE Publications ; 2020
    In:  Journal of Industrial Textiles Vol. 49, No. 6 ( 2020-01), p. 748-772
    Details
    In: Journal of Industrial Textiles, SAGE Publications, Vol. 49, No. 6 ( 2020-01), p. 748-772
    Abstract: With increasing demands on the high-performance and environmental-friendly melt-blown nonwovens (MBs) for separation and filtration, herein, we reported a poly(lactic acid)/polyamide 11 (PLA/PA11) 100% bio-based MBs in situ compatibilized by dual-monomer glycidyl methacrylate–styrene melt-grafted poly(lactic acid) (PLA-g-(St-co-GMA)). The morphology, crystallization, thermal and rheological behaviors of reactive extruded PLA/PA11/PLA-g-(St-co-GMA) melt blends were investigated, and the structure and filtration performance of corresponding MBs were fully characterized. The results indicated that the interface between PLA and PA11 were effectively improved due to the compatibilizer of PLA-g-(St-co-GMA). PA11 promoted the cold crystallization and enhanced the thermal stability of PLA matrix. The reactive blends displayed a higher viscosity with unchanged rheological behaviors compared with PLA. In comparison with PLA MBs, the average fiber diameter and pore size of PLA/PA11/PLA-g-(St-co-GMA) MBs were slightly increased, whereas the strength and toughness were significantly improved. All the PLA/PA11/PLA-g-(St-co-GMA) MBs presented high air permeability and low filtration resistance. High filtration efficiency ( 〉 99.8%) could also be obtained especially for the target particles with diameters larger than 2.5 µm.
    Type of Medium: Online Resource
    ISSN: 1528-0837 , 1530-8057
    URL: Article
    DOI: 10.1177/1528083718795913
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2095351-3
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