In:
Hormone Research in Paediatrics, S. Karger AG, Vol. 68, No. 1 ( 2007), p. 1-7
Abstract:
〈 i 〉 Background: 〈 /i 〉 Concomitant evaluation of the metabolic and growth-promoting effects of growth hormone (GH) therapy in Turner syndrome (TS) may be used in the prediction of the growth response to GH therapy. 〈 i 〉 Aim: 〈 /i 〉 To evaluate the metabolic effects of GH therapy in TS and correlation with the short-term growth response. 〈 i 〉 Patients: 〈 /i 〉 24 prepubertal children with TS, aged 9.4 ± 2.6 years were followed for auxology and IGF-I, IGFBP-3, leptin, ghrelin, adiponectin, lipids and OGTT results in a prospective multicenter study. 〈 i 〉 Intervention: 〈 /i 〉 GH (Genotropin®) in a dose of 50 µg/kg/day for 1 year. 〈 i 〉 Results: 〈 /i 〉 Height standard deviation score (SDS) increased from –3.9 ± 1.5 to –3.5 ± 1.4 (p = 0.000) on therapy. BMI did not change. IGF-I SDS increased from –2.3 ± 0.4 to –1.6 ± 1.1 at 3 and 6 months (p = 0.001) and decreased thereafter. Serum leptin decreased significantly from 2.3 ± 3.9 to 1.7 ± 5.3 ng/ml (p = 0.022) at 3 months and increased afterwards. Serum ghrelin decreased from 1.2 ± 0.8 to 0.9 ± 0.4 ng/ml (p = 0.005) with no change in adiponectin. Basal and stimulated insulin levels also increased significantly. Δ height SDS over 1 year showed a significant correlation with Δ IGF-I 〈 sub 〉 0–3 months 〈 /sub 〉 (r = 0.450, p = 0.027). 〈 i 〉 Conclusion: 〈 /i 〉 IGF-I may be considered as a marker of growth response in TS at short term. Leptin shows a decrease at short term but does not have a correlation with growth response. The decrease in ghrelin in face of unchanged weight seems to be associated with increase in IGF-I and insulin levels. The unchanged adiponectin levels in spite of an increase in insulin levels indicates that adiponectin is mainly affected by weight, not insulin.
Type of Medium:
Online Resource
ISSN:
1663-2818
,
1663-2826
Language:
English
Publisher:
S. Karger AG
Publication Date:
2007
detail.hit.zdb_id:
2540224-9
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