In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 2 ( 2023-2-24), p. e0282047-
Abstract:
To investigate the association of systemic oxidative stress markers and optic nerve head (ONH) blood flow in normal-tension glaucoma (NTG) patients, as well as sex differences in this association. Methods This was a cross-sectional study of 235 eyes with NTG of 134 patients (56 male, 78 female; mean age, 60.9±14.1 years). Laser speckle flowgraphy (LSFG) was used to measure ONH blood flow (mean blur rate in the tissue area of the ONH; MBR-T) and LSFG pulse-waveform parameters, including flow acceleration index in the tissue area of the ONH (FAI-T). Oxidative stress markers, diacron-reactive oxygen metabolites (d-ROMs), and biological antioxidant potential (BAP) were measured with a free radical elective evaluator. Spearman’s rank correlation test and a multivariate linear mixed-effect model were used to investigate factors associated with ONH blood flow. Results MBR-T was significantly correlated with age (rs = -0.28, p 〈 0.001), mean arterial pressure (rs = -0.20, p = 0.002), intraocular pressure (rs = 0.24, p 〈 0.001), peripapillary retinal nerve fiber layer thickness (rs = 0.62, p 〈 0.001), and disc area (rs = -0.26, p 〈 0.001), but not with serum d-ROM level. Separate analyses of the subjects divided by sex showed that BAP was positively correlated to MBR-T (rs = 0.21, p = 0.036) and FAI-T (rs = 0.36, p 〈 0.001) only in male subjects. Similarly, BAP was significantly associated with MBR-T (β = 0.25, p = 0.026) and FAI-T (β = 0.37, p 〈 0.001) in male subjects in a multivariate linear mixed-effect model. Conclusion A lower serum antioxidant level, as indicated by BAP, was associated with reduced ONH blood flow only in male NTG patients. Our findings suggest that there are sex differences in the involvement of oxidative stress in the pathogenesis of reduced ocular blood flow in NTG.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0282047
DOI:
10.1371/journal.pone.0282047.t001
DOI:
10.1371/journal.pone.0282047.t002
DOI:
10.1371/journal.pone.0282047.t003
DOI:
10.1371/journal.pone.0282047.t004
DOI:
10.1371/journal.pone.0282047.s001
DOI:
10.1371/journal.pone.0282047.s002
DOI:
10.1371/journal.pone.0282047.s003
DOI:
10.1371/journal.pone.0282047.r001
DOI:
10.1371/journal.pone.0282047.r002
DOI:
10.1371/journal.pone.0282047.r003
DOI:
10.1371/journal.pone.0282047.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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