In:
Acta Radiologica, SAGE Publications, Vol. 61, No. 10 ( 2020-10), p. 1350-1358
Abstract:
Phase-contrast magnetic resonance imaging (PC-MRI) can determine pulmonary hemodynamics non-invasively. Pulmonary hypertension causes changes in pulmonary hemodynamics and is a factor for acute exacerbation and death in interstitial lung diseases (ILD). Purpose To determine associations between pulmonary hemodynamics measured by PC-MRI and short-term mortality in patients with ILD. Material and Methods Pulmonary hemodynamics, measured by PC-MRI in 43 patients with ILD, were reviewed retrospectively. Evaluation parameters included heart rate, right cardiac output, average flow, average velocity, acceleration time, acceleration volume (AV), maximal change in flow rate during ejection (M), M/AV, maximum area, minimum area, and relative area change in the pulmonary artery (PA). All causes of death within one year from the day of the MRI examination were assessed by reviewing medical records. Associations between evaluation parameters and outcome were determined by univariate and multivariate Cox regression analysis. Results Six patients (13.9%) died by the one-year follow-up. Age (hazard ratio [HR] 1.116, 95% confidence interval [CI] 1.015–1.269), average flow (HR 0.932, 95% CI 0.870–0.984), average velocity (HR 0.778, 95% CI 0.573–0.976), right cardiac output (HR 0.870, 95% CI 0.758–0.967), AV (HR 0.840, 95% CI 0.669–0.985), M/AV (HR 1.008, 95% CI 1.001–1.014), and PA relative area change (HR 0.715, 95% CI 0.459–0.928) predicted death in univariate Cox analysis. Multivariate Cox analysis showed decreased right cardiac output (HR 0.547, 95% CI 0.160–0.912) and decreased PA relative area change (HR 0.538, 95% CI 0.177–0.922) were independently associated with death. Conclusion Reduction in right cardiac output and decreased PA relative area change, detected by PC-MRI, were associated with increased mortality in ILD.
Type of Medium:
Online Resource
ISSN:
0284-1851
,
1600-0455
DOI:
10.1177/0284185120901503
Language:
English
Publisher:
SAGE Publications
Publication Date:
2020
detail.hit.zdb_id:
2024579-8
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