In:
CNS Spectrums, Cambridge University Press (CUP), Vol. 26, No. 3 ( 2021-06), p. 299-306
Abstract:
It is well-known that attention deficit hyperactivity disorder (ADHD) is associated with changes in the dopaminergic system. However, the relationship between central dopaminergic tone and the blood oxygen level-dependent (BOLD) signal during receipt of rewards and penalties in the corticostriatal pathway in adults with ADHD is unclear. Methods Single-photon emission computed tomography with [ 99m TC]TRODAT-1 was used to assess striatal dopamine transporter (DAT) availability. Event-related functional magnetic resonance imaging was conducted on subjects performing the Iowa Gambling Test. Result DAT availability was found to be associated with the BOLD response, which was a covariate of monetary loss, in the medial prefrontal cortex ( r = 0.55, P = .03), right ventral striatum ( r = 0.69, P = .003), and right orbital frontal cortex ( r = 0.53, P = .03) in adults with ADHD. However, a similar correlation was not found in the controls. Conclusions The results confirmed that dopaminergic tone may play a different role in the penalty-elicited response of adults with ADHD. It is plausible that a lower neuro-threshold accompanied by insensitivity to punishment could be exacerbated by the hypodopaminergic tone in ADHD.
Type of Medium:
Online Resource
ISSN:
1092-8529
,
2165-6509
DOI:
10.1017/S1092852920001133
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2021
detail.hit.zdb_id:
2149753-9
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