In:
Natural Product Communications, SAGE Publications, Vol. 12, No. 6 ( 2017-06), p. 1934578X1701200-
Abstract:
Two new steroids, (24 R)-22, 23-dihydroxy-ergosta-4,6,8(14)-trien-3-one 23-β-D-glucopyranoside (1), and xylarester (2), together with 16 known compounds were isolated from the extract of endophytic Xylaria sp. solid culture. Their structures were elucidated by spectroscopic methods. Compound 2 has an unprecedent ergosta skeleton with a six-membered lactonic group in A ring. The X-ray single crystal diffraction data of 4,7-dihydroxy-13-tetradeca-2,5,8-trienolide (4) were also reported for the first time. The antibacterial, anti-acetylcholinesterase, nitric oxide inhibition and cytotoxic activities of 1–3 were investigated. Compound 1 showed cytotoxicity to MCF-7 with the ratio of inhibition at 72 % for a concentration at 40 μM.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X1701200617
Language:
English
Publisher:
SAGE Publications
Publication Date:
2017
detail.hit.zdb_id:
2430442-6
SSG:
15,3
Permalink