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  • Wiley  (33)
  • Yang, Xiaoming  (33)
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  • Wiley  (33)
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  • 1
    Online Resource
    Online Resource
    Structurally Optimized Fluorinated Small‐Sized Graphene Oxide for Enhanced Magnetic Resonance Imaging during Pregnancy
    Wiley ; 2024
    In:  Advanced Functional Materials Vol. 34, No. 11 ( 2024-03)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 34, No. 11 ( 2024-03)
    Abstract: Gadolinium‐based complex contrast agents (GBCAs), frequently applied in magnetic resonance imaging (MRI), are associated with severe acute anaphylactic shock and incurable nephrogenic systemic fibrosis. Besides, the repeated use of GBCAs may result in the accumulation in various tissues. Given these potential adverse effects, GBCAs have not been well used during pregnancy. Herein, a novel metal‐free T 2 ‐weighted MRI nanoprobe, designated fluorinated small‐sized graphene oxide with optimized fluorine content (LF‐sGO), is developed via graphene oxide materials. By introducing specific polar C─F bonds onto the small‐sized graphene oxide (sGO) skeleton, the prepared nanoprobe exhibits excellent water solubility, as well as superior MRI capabilities, thereby furnishing high‐resolution MRI anatomical information. Furthermore, the free radicals on LF‐sGO stabilized by C─F bonds confer LF‐sGO enrichment in the tumor region, enabling comprehensive imaging capability. The cytotoxicity study in vitro indicates that LF‐sGO has the potential to serve as a biocompatible imaging probe. Moreover, detailed in vivo studies on pregnant mice and zebrafish adequately demonstrate that microinjection of LF‐sGO does not induce dysontogensis and teratogenesis. This study successfully showcases a metal‐free nanoprobe that exhibits exceptional MRI capabilities for the purpose of tumor diagnosis. Notably, this nanoprobe holds promise for safe and effective tumor diagnosis during pregnancy.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v34.11
    DOI: 10.1002/adfm.202310168
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    OsPKpα1 encodes a plastidic pyruvate kinase that affects starch biosynthesis in the rice endosperm
    Wiley ; 2018
    In:  Journal of Integrative Plant Biology Vol. 60, No. 11 ( 2018-11), p. 1097-1118
    Details
    In: Journal of Integrative Plant Biology, Wiley, Vol. 60, No. 11 ( 2018-11), p. 1097-1118
    Abstract: Pyruvate kinase (PK) is a key enzyme in glycolysis and carbon metabolism. Here, we isolated a rice ( Oryza sativa ) mutant, w59 , with a white‐core floury endosperm. Map‐based cloning of w59 identified a mutation in OsPKpα1 , which encodes a plastidic isoform of PK (PKp). OsPKpα1 localizes to the amyloplast stroma in the developing endosperm, and the mutation of OsPKpα1 in w59 decreases the plastidic PK activity, resulting in dramatic changes to the lipid biosynthesis in seeds. The w59 grains were also characterized by a marked decrease in starch content. Consistent with a decrease in number and size of the w59 amyloplasts, large empty spaces were observed in the central region of the w59 endosperm, at the early grain‐filling stage. Moreover, a phylogenetic analysis revealed four potential rice isoforms of OsPKp. We validated the in vitro PK activity of these OsPKps through reconstituting active PKp complexes derived from inactive individual OsPKps, revealing the heteromeric structure of rice PKps, which was further confirmed using a protein–protein interaction analysis. These findings suggest a functional connection between lipid and starch synthesis in rice endosperm amyloplasts.
    Type of Medium: Online Resource
    ISSN: 1672-9072 , 1744-7909
    URL: Issue
    URL: Article
    DOI: 10.1111/jipb.v60.11
    DOI: 10.1111/jipb.12692
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2130095-1
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore–microtubule attachments
    Wiley ; 2010
    In:  The EMBO Journal Vol. 29, No. 17 ( 2010-9-1), p. 2953-2965
    Details
    In: The EMBO Journal, Wiley, Vol. 29, No. 17 ( 2010-9-1), p. 2953-2965
    Type of Medium: Online Resource
    ISSN: 0261-4189 , 1460-2075
    URL: Article
    DOI: 10.1038/emboj.2010.174
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 1467419-1
    detail.hit.zdb_id: 586044-1
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    MTNR1B loss promotes chordoma recurrence by abrogating melatonin‐mediated β‐catenin signaling repression
    Wiley ; 2019
    In:  Journal of Pineal Research Vol. 67, No. 2 ( 2019-09)
    Details
    In: Journal of Pineal Research, Wiley, Vol. 67, No. 2 ( 2019-09)
    Abstract: Chordoma is an extremely rare malignant bone tumor with a high rate of relapse. While cancer stem cells (CSCs) are closely associated with tumor recurrence, which depend on its capacity to self‐renew and induce chemo‐/radioresistance, whether and how CSCs participate in chordoma recurrence remains unclear. The current study found that tumor cells in recurrent chordoma displayed more dedifferentiated CSC‐like properties than those in corresponding primary tumor tissues. Meanwhile, MTNR1B deletion along with melatonin receptor 1B (MTNR1B) down‐regulation was observed in recurrent chordoma. Further investigation revealed that activation of Gαi2 by MTNR1B upon melatonin stimulation could inhibit SRC kinase activity via recruiting CSK and SRC, increasing SRC Y530 phosphorylation, and decreasing SRC Y419 phosphorylation. This subsequently suppressed β‐catenin signaling and stemness via decreasing β‐catenin p‐Y86/Y333/Y654. However, MTNR1B loss in chordoma mediated increased CSC properties, chemoresistance, and tumor progression by releasing melatonin's repression of β‐catenin signaling. Clinically, MTNR1B deletion was found to correlate with patients’ survival. Together, our study establishes a novel convergence between melatonin and β‐catenin signaling pathways and reveals the significance of this cross talk in chordoma recurrence. Besides, we propose that MTNR1B is a potential biomarker for prediction of chordoma prognosis and selection of treatment options, and chordoma patients might benefit from targeting MTNR1B/Gαi2/SRC/β‐catenin axis.
    Type of Medium: Online Resource
    ISSN: 0742-3098 , 1600-079X
    URL: Issue
    URL: Article
    DOI: 10.1111/jpi.v67.2
    DOI: 10.1111/jpi.12588
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2027992-9
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  • 5
    Online Resource
    Online Resource
    miR‐486 regulates metastasis and chemosensitivity in hepatocellular carcinoma by targeting CLDN10 and CITRON
    Wiley ; 2015
    In:  Hepatology Research Vol. 45, No. 13 ( 2015-12), p. 1312-1322
    Details
    In: Hepatology Research, Wiley, Vol. 45, No. 13 ( 2015-12), p. 1312-1322
    Abstract: miRNA‐486 (miR‐486) was first identified from the human fetal liver cDNA library and considered to be associated with hepatocellular carcinoma (HCC) development. Its roles in regulation of HCC metastasis and chemosensitivity have not been explored yet. Methods miR‐486 expression in HCC tissues, cell lines and serum was evaluated by real‐time polymerase chain reaction. miR‐486 overexpression or downregulation in the cell lines SMMC‐7721/LM3 was conducted by lentivirus transfection. Cell proliferation, migration and apoptosis were quantitated using commercial assays. Matrix metalloproteinase activity was quantitated by gelatin zymography. The target genes of miR‐486 were screened by 3′‐untranslated region luciferase report assays and their function was validated by small RNA interference. Results We show here that miR‐486 is frequently down‐expressed in HCC tissues and cell lines. Lentivirus‐mediated restoration of miR‐486 in HCC cell lines resulted in significant reduction in the ability of cell growth, colony formation and migration. However, miR‐486 inhibition enhances proliferation and invasion of HCC cells. Two genes, CITRON and CLDN10 which regulate cell proliferation and invasion, respectively, were identified as the direct targets of miR‐486 in HCC cells. CITRON and CLDN10 knockdown by siRNA results in similar phenotypes of miR‐486 restoration in HCC cell lines. In addition, miR‐486 enhances the chemosensitivity of HCC cells to sorafenib. Conclusion Our data indicated that miR‐486 may function as a novel tumor suppressor in HCC.
    Type of Medium: Online Resource
    ISSN: 1386-6346 , 1872-034X
    URL: Issue
    URL: Article
    DOI: 10.1111/hepr.v45.13
    DOI: 10.1111/hepr.12500
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2006439-1
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  • 6
    Online Resource
    Online Resource
    Effects of defect dipoles on tunable dielectric response in relaxor ferroelectric ceramics
    Wiley ; 2020
    In:  Journal of the American Ceramic Society Vol. 103, No. 11 ( 2020-11), p. 6445-6452
    Details
    In: Journal of the American Ceramic Society, Wiley, Vol. 103, No. 11 ( 2020-11), p. 6445-6452
    Abstract: Tunable dielectric materials have drawn much attention due to their wide applications including capacitors and microwave tunable devices. Ferroelectrics materials have special spontaneous polarization which can be reversibly switched by an external electric field. Therefore, tunable dielectric constant can be easily achieved in ferroelectrics. However, the study of nonlinear dielectric response induced by defect dipoles is rarely concerned. Here, we report the effects of defect dipoles on tunable dielectric response under alternative current (AC) and direct current (DC) electric field in defect dipoles introduced Pb(Lu 1/2 Nb 1/2 )O 3 –PbTiO 3 ceramics. A modified Rayleigh model is proposed to successfully characterize dielectric nonlinearity and reveals the interaction between domain walls and defect dipoles. The defect dipoles had more sensitive effect on dielectric response under AC field than that of defect dipoles‐free samples. The drop of intrinsic dielectric contribution under AC field results from the detriment effect of defect dipoles. The irreversible contribution is altered by the movements of defect dipoles under AC field, subsequently inducing the nonlinearity of dielectric response. Samples with defect dipoles have larger tunable scope of dielectric properties than that of defect dipoles‐free samples. The present work discovers the potential of application of defect dipoles‐tuned dielectric response ferroelectrics in devices which requires both high AC and DC biases, and help to better understand the complex dielectric response of ferroelectrics.
    Type of Medium: Online Resource
    ISSN: 0002-7820 , 1551-2916
    URL: Issue
    URL: Article
    DOI: 10.1111/jace.v103.11
    DOI: 10.1111/jace.17383
    RVK:
    VA 1120
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2008170-4
    detail.hit.zdb_id: 219232-9
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  • 7
    Online Resource
    Online Resource
    Loss of exosomal miR‐26a‐5p contributes to endometrial cancer lymphangiogenesis and lymphatic metastasis
    Wiley ; 2022
    In:  Clinical and Translational Medicine Vol. 12, No. 5 ( 2022-05)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 12, No. 5 ( 2022-05)
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v12.5
    DOI: 10.1002/ctm2.846
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2697013-2
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  • 8
    Online Resource
    Online Resource
    Diffusion‐weighted MRI monitoring of pancreatic cancer response to radiofrequency heat‐enhanced intratumor chemotherapy
    Wiley ; 2013
    In:  NMR in Biomedicine Vol. 26, No. 12 ( 2013-12), p. 1762-1767
    Details
    In: NMR in Biomedicine, Wiley, Vol. 26, No. 12 ( 2013-12), p. 1762-1767
    Abstract: The aim of this study was to evaluate the feasibility of using diffusion‐weighted MRI to monitor the early response of pancreatic cancers to radiofrequency heat (RFH)‐enhanced chemotherapy. Human pancreatic carcinoma cells (PANC‐1) in different groups and 24 mice with pancreatic cancer xenografts in four groups were treated with phosphate‐buffered saline (PBS) as a control, RFH at 42 °C, gemcitabine and gemcitabine plus RFH at 42 °C. One day before and 1, 7 and 14 days after treatment, diffusion‐weighted MRI and T 2 ‐weighted imaging were applied to monitor the apparent diffusion coefficients (ADCs) of tumors and tumor growth. MRI findings were correlated with the results of tumor apoptosis analysis. In the in vitro experiments, the quantitative viability assay showed lower relative cell viabilities for treatment with gemcitabine plus RFH at 42 °C relative to treatment with RFH only and gemcitabine only (37 ± 5% versus 65 ± 4% and 58 ± 8%, respectively, p   〈  0.05). In the in vivo experiments, the combination therapy resulted in smaller relative tumor volumes than RFH only and chemotherapy only (0.82 ± 0.17 versus 2.23 ± 0.90 and 1.64 ± 0.44, respectively, p  = 0.003). In vivo , 14‐T MRI demonstrated a remarkable decrease in ADCs at day 1 and increased ADCs at days 7 and 14 in the combination therapy group. The apoptosis index in the combination therapy group was significantly higher than those in the chemotherapy‐only, RFH‐only and PBS treatment groups (37 ± 6% versus 20 ± 5%, 8 ± 2% and 3 ± 1%, respectively, p   〈  0.05). This study confirms that it is feasible to use MRI to monitor RFH‐enhanced chemotherapy in pancreatic cancers, which may present new options for the efficient treatment of pancreatic malignancies using MRI/RFH‐integrated local chemotherapy. Copyright © 2013 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0952-3480 , 1099-1492
    URL: Issue
    URL: Article
    DOI: 10.1002/nbm.v26.12
    DOI: 10.1002/nbm.3014
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2002003-X
    detail.hit.zdb_id: 1000976-0
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  • 9
    Online Resource
    Online Resource
    HPS protects the liver against steatosis, cell death, inflammation, and fibrosis in mice with steatohepatitis
    Wiley ; 2022
    In:  The FEBS Journal Vol. 289, No. 17 ( 2022-09), p. 5279-5304
    Details
    In: The FEBS Journal, Wiley, Vol. 289, No. 17 ( 2022-09), p. 5279-5304
    Abstract: Hepassocin (HPS) is a hepatokine associated with metabolic regulation and development of non‐alcoholic steatohepatitis (NASH). However, previous reports on HPS are controversial and its true function is not yet understood. Here, we demonstrated that hepatic HPS expression levels were upregulated in short‐term feeding and downregulated in long‐term feeding in high‐fat diet (HFD)‐ and methionine‐ and choline‐deficient (MCD) diet‐fed mice, as well as in genetically obese ( ob/ob ) mice. HFD‐ and MCD‐induced hepatic steatosis, inflammation, apoptosis, and fibrosis were more pronounced in HPS knockout mice than in the wild‐type mice. Moreover, HPS depletion aggravated HFD‐induced insulin resistance. By contrast, HPS administration improved MCD‐ or HFD‐induced liver phenotypes and insulin resistance in HPS knockout and wild‐type mice. Mechanistic studies revealed that MCD‐induced hepatic oxidative stress was significantly increased by HPS deficiency and could be attenuated by HPS administration. Furthermore, palmitic acid‐induced lipid accumulation and oxidative stress were exclusively enhanced in HPS knockout hepatocytes and diminished by HPS cotreatment. These data suggest that HPS ameliorates NASH in mice, at least in part, by inhibiting the oxidative stress. HPS expression levels are downregulated in human fatty liver tissues, suggesting that it may play an important protective role in NASH. Collectively, our findings provide clear genetic evidence that HPS has beneficial effects on the development of steatohepatitis in mice and suggest that upregulating HPS signaling may represent an effective treatment strategy for NASH.
    Type of Medium: Online Resource
    ISSN: 1742-464X , 1742-4658
    URL: Issue
    URL: Article
    DOI: 10.1111/febs.v289.17
    DOI: 10.1111/febs.16430
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2172518-4
    SSG: 12
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  • 10
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    Online Resource
    Yellow‐Fluorescence Carbon Dots Employed for pH Sensing and Detection of Tigecycline †
    Wiley ; 2023
    In:  Chinese Journal of Chemistry
    Details
    In: Chinese Journal of Chemistry, Wiley
    Abstract: Long‐wavelength fluorescence carbon dots (CDs) show great importance in multiple fields, especially for the biochemical sensing. Here, we proposed one type of CDs doped with nitrogen and sulfur through the hydrothermal method, which exhibited obvious yellow‐fluorescence in aqueous solution. Importantly, the fluorescence intensity of CDs decreased with pH decreasing in the acidic range, thus a linear relationship between pH and fluorescence intensity was established, exhibiting the potential of pH sensing. Additionally, introducing tigecycline into CDs resulted in their decreased fluorescence, thus, we further established a strategy of detecting tigecycline with the concentration range of 200 μM to 7 nM. Meanwhile, we elucidated the static quenching as the major mechanism for CDs responding tigecycline, which was induced by the formed new complex between CDs and tigecycline. Furthermore, the practicality of the method was verified by examining the recovery of tigecycline in the actual lake‐water samples.
    Type of Medium: Online Resource
    ISSN: 1001-604X , 1614-7065
    URL: Article
    DOI: 10.1002/cjoc.202300421
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2144352-X
    SSG: 6,25
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