In:
Journal of Separation Science, Wiley, Vol. 43, No. 7 ( 2020-04), p. 1339-1347
Abstract:
Taxanes are natural anticancer constituents, and the sample preparation from matrix normally depends on organochlorine solvents. In this study, green and natural menthol‐based aqueous deep eutectic solvent was synthesized and used for sample preparation for taxanes. Five key parameters were optimized and the optimal preparation conditions were as follows: menthol/1‐propanol ratio 1:1 (mol/mol), solid–liquid ratio 1:30 g/mL, extraction time 30 min, ultrasonic power 250 W, and water content 80%. Under the above conditions, the total extraction efficiency of seven main taxanes was 1.25‐ to 1.44‐fold to the conventional methods. In addition, a high‐performance liquid chromatography method with C 18 column was established for quantitation of seven main taxanes in 〈 25 min, which had excellent linearity ( R 2 〉 0.9986), precision (relative standard deviation 〈 3.00%), repeatability (relative standard deviation 〈 3.69%), and recovery (90.26–109.00%). This method performed the extraction, and enrichment processes simultaneously, and it had advantages such as high extraction efficiency, simple operation, low cost, and eco‐friendliness. This work indicated that the natural menthol‐based deep eutectic solvent aqueous could be an excellent alternative to the sample preparation from Taxus or other plants.
Type of Medium:
Online Resource
ISSN:
1615-9306
,
1615-9314
DOI:
10.1002/jssc.201900754
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2037737-X
detail.hit.zdb_id:
2047990-6
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