In:
Journal of Chemical Research, SAGE Publications, Vol. 39, No. 9 ( 2015-09), p. 550-552
Abstract:
Two novel syntheses of the flavone luteolin are described. In the first, 3,5-dimethoxyphenol was converted to 2-hydroxy-4,6-dimethoxyacetophenone and then by condensation with 3,4-dimethoxybenzaldehyde to 2′-hydroxy-3,4,4′,6′-tetramethoxychalcone. In the second, the chalcone step was prepared in which 3,5-dimethoxyphenol was acylated with 3,4-dimethoxycinnamoyl chloride. The chalcone was then cyclised with iodine and demethylated with pyridine hydrochloride to form luteolin in 47% and 40% overall yield, respectively. Several disadvantages of previous syntheses like long reaction time, harsh reaction conditions and low overall yield have been overcome.
Type of Medium:
Online Resource
ISSN:
1747-5198
,
2047-6507
DOI:
10.3184/174751915X14404221529907
Language:
English
Publisher:
SAGE Publications
Publication Date:
2015
detail.hit.zdb_id:
3010810-X
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