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  • Oxford University Press (OUP)  (16)
  • Yang, Jia  (16)
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  • Oxford University Press (OUP)  (16)
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  • 1
    Online Resource
    Online Resource
    Pu-miR172d regulates stomatal density and water-use efficiency via targeting PuGTL1 in poplar
    Oxford University Press (OUP) ; 2021
    In:  Journal of Experimental Botany Vol. 72, No. 4 ( 2021-02-24), p. 1370-1383
    Details
    In: Journal of Experimental Botany, Oxford University Press (OUP), Vol. 72, No. 4 ( 2021-02-24), p. 1370-1383
    Abstract: miRNAs play essential regulatory roles in many aspects of plant development and in responses to abiotic and biotic stresses. Here, we characterize Pu-miR172d, which acts as a negative regulator of stomatal density by directly repressing the expression of PuGTL1 in Populus ussuriensis. Quantitative real-time PCR and GUS reporter analyses showed that Pu-miR172d was strongly expressed in the guard cells of young leaves. Overexpression of Pu-miR172d significantly decreased stomatal density, resulting in increases in water use efficiency (WUE) and drought tolerance by reducing net photosynthetic rate, stomatal conductance, and transpiration. Molecular analysis showed that PuGTL1 was a major target of Pu-miR172d cleavage. Moreover, PuGTL1-SRDX plants, in which PuGTL1 is suppressed, phenocopied Pu-miR172d-overexpression lines with reduced stomatal density and enhanced WUE. The expression of PuSDD1, a negative regulator of stomatal development, was significantly increased in young leaves of both Pu-miR172d-overexpression and PuGTL1-SRDX plants. RNA-seq analysis of mature leaves indicated that overexpression of Pu-miR172d decreased the expression of many genes related to photosynthesis. Our findings show that the Pu-miR172d/PuGTL1/PuSDD1 module plays an important role in stomatal differentiation, and hence it is a potential target for engineering improved drought tolerance in poplar.
    Type of Medium: Online Resource
    ISSN: 0022-0957 , 1460-2431
    URL: Article
    DOI: 10.1093/jxb/eraa493
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1466717-4
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    P0592RISK FACTORS FOR SEPSIS ASSCOCIATED-ACUTE KIDNEY INJURY IN INTENSIVE CARE UNIT PATIENTS
    Oxford University Press (OUP) ; 2020
    In:  Nephrology Dialysis Transplantation Vol. 35, No. Supplement_3 ( 2020-06-01)
    Details
    In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 35, No. Supplement_3 ( 2020-06-01)
    Abstract: To explore the risk factors of acute kidney injury in patients with sepsis in intensive care unit (ICU). Method The medical records of patients diagnosed with sepsis in ICU of west China hospital of Sichuan university from March 2009 to June 2016 were retrospectively analyzed. Differences between AKI group and Non-AKI group in general data, background disease, ICU entry and exit dates, complications, laboratory data and other related data were analyzed through univariate and multivariate statistical methods. Results A total of 2331 patients with sepsis were included in the study, including 626 patients in the AKI group and 1695 patients in the Non-AKI group. The multivariate logistic regression analysis confirmed that age & gt;40 yr. [odds ratio (OR) =2.811], diabetes (OR=2.818), hypertension/coronary heart disease (OR=1.781), CKD (OR=13.221), the length of ICU stay ≥14 days (OR=3.327), heart failure (OR=2.316), ARDS (OR=2.105), SAP (OR=2.566), hypotension (OR=2.048), hypoproteinemia (OR=1.607), lactic acidosis (OR=2.380), hypoproteinemia (OR=1.607), organ failure & gt;1 (OR=4.604),WBC & gt; 10 ×109/L (OR=4.197), serum creatinine (OR=4.535), PCT (OR=1.808), Cys-C (OR=7.066), mild anemia (OR=2.321), moderate anemia (OR=4.047), and severe anemia (OR=6.100) were all independent risk factors of SA-AKI. Conclusion A variety of risk factors are related to the occurrence of SA-AKI. Early identification and monitoring of risk factors for SA-AKI and early prevention of AKI can improve the prognosis of sepsis patients.
    Type of Medium: Online Resource
    ISSN: 0931-0509 , 1460-2385
    URL: Article
    DOI: 10.1093/ndt/gfaa142.P0592
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1465709-0
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  • 3
    Online Resource
    Online Resource
    No Evidence for Widespread Positive Selection Signatures in Common Risk Alleles Associated with Schizophrenia
    Oxford University Press (OUP) ; 2020
    In:  Schizophrenia Bulletin Vol. 46, No. 3 ( 2020-04-10), p. 603-611
    Details
    In: Schizophrenia Bulletin, Oxford University Press (OUP), Vol. 46, No. 3 ( 2020-04-10), p. 603-611
    Abstract: Schizophrenia poses an evolutionary-genetic paradox as it exhibits strongly negative fitness effects (early mortality and decreased fecundity), yet it persists at a prevalence of approximately 1% worldwide. Evidence from several studies have suggested that schizophrenia is evolved and maintained in part as a maladaptive byproduct of recent positive selection and adaptive evolution in human beings. However, inconsistent results have been also proposed, challenging the recent positive selection theory to explain the high population frequency of schizophrenia-associated alleles. Here, we used public domain data to locate signatures of positive selection based on genetic diversity, derived allele frequency, differentiation between populations, and long haplotypes at schizophrenia-associated single nucleotide polymorphisms (SNPs) and randomly selected SNPs (as negative controls). We found evidence for positive selection at 10 out of the 105 schizophrenia-associated SNPs, while 5 of these SNPs involved positive selection for the protective allele. Taken together, the absence of widespread positive selection signals at the schizophrenia-associated SNPs, along with the fact that half of the positive selection favored the protective allele, provide little evidence supporting the positive selection theory in schizophrenia.
    Type of Medium: Online Resource
    ISSN: 0586-7614 , 1745-1701
    URL: Article
    DOI: 10.1093/schbul/sbz048
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2180196-4
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis
    Oxford University Press (OUP) ; 2020
    In:  Protein & Cell Vol. 11, No. 11 ( 2020-11), p. 852-857
    Details
    In: Protein & Cell, Oxford University Press (OUP), Vol. 11, No. 11 ( 2020-11), p. 852-857
    Type of Medium: Online Resource
    ISSN: 1674-800X , 1674-8018
    URL: Article
    DOI: 10.1007/s13238-020-00746-2
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2543451-2
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  • 5
    Online Resource
    Online Resource
    P0632RISK FACTORS FOR ACUTE KIDNEY INJURE AMONG PATIENTS WITH RHABDOMYOLYSIS
    Oxford University Press (OUP) ; 2020
    In:  Nephrology Dialysis Transplantation Vol. 35, No. Supplement_3 ( 2020-06-01)
    Details
    In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 35, No. Supplement_3 ( 2020-06-01)
    Abstract: Rhabdomyolysis (RM) is a syndrome characterized by the abruption of the integrity of skeletal muscle cells with subsequent release of intracellular components into extracellular fluid and circulation. Acute kidney injury (AKI) is a life-threatening complication of rhabdomyolysis. The aim of this study was to assess patients at high risk for the occurrence of AKI defined by KDIGO criteria and in-hospital mortality. Method We performed a retrospective study of patients with creatine kinase levels in excess of 1000 U/L, admitted in West China Hospital of Sichuan University from January 2011 to march 2019. The sociodemographic, clinical and laboratory data of the patients were obtained in an electronic medical record database. Univariate and multiple regression analyses were conducted. Results 329 patients were included in our study. The incidence of AKI was 61.4%, the overall mortality was 19.8%, and patients with AKI tend to have higher mortality than those without AKI (24.8% versus 11.8%, P & lt; 0.01). The clinical conditions most frequently associated with rhabdomyolysis were trauma (28.3%), infection (14.6%), bee stings (12.8%), thoracic and abdominal operations (11.2%) and exercise (7.0%). Patients resulted from sepsis, bee stings and acute alcoholism were susceptible to AKI. The risk factors for the occurrence of AKI among rhabdomyolysis patients included age≥60 (OR 3.070), chronic alcoholism (OR 3.256), hypertension (OR 4.252), multiple organ dysfunction syndrome (OR 7.244), elevated white blood cell counts (OR 1.047) and serum phosphorus (OR 5.526). Age≥60 (OR 3.188), multiple organ dysfunction syndrome (OR 2.262), diabetes (OR 2.746) and elevated prothrombin time (OR 1.079) were independent risk factors for in-hospital mortality of rhabdomyolysis patients with AKI. Conclusion AKI is independently associated with mortality in rhabdomyolysis patients. Several risk factors were found to be associated with the occurrence of AKI and in-hospital mortality. The findings aiming to suggest early prevention of AKI should target on patients with high risk and more effective management to improve the quality of medical care.
    Type of Medium: Online Resource
    ISSN: 0931-0509 , 1460-2385
    URL: Article
    DOI: 10.1093/ndt/gfaa142.P0632
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1465709-0
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  • 6
    Online Resource
    Online Resource
    P0626THE RISK FACTORS OF ACUTE KIDNEY INJURY CAUSED BY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
    Oxford University Press (OUP) ; 2020
    In:  Nephrology Dialysis Transplantation Vol. 35, No. Supplement_3 ( 2020-06-01)
    Details
    In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 35, No. Supplement_3 ( 2020-06-01)
    Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome caused by uncontrolled natural killer (NK) cell and cytotoxic T cell activation, resulting in the overproduction of proinflammatory cytokines and hemophagocytosis. Acute kidney injury (AKI) characterized by rapid loss of renal excretion function is the most common complication of HLH in the kidney. In this retrospective study, we aimed to find the risk factors of AKI in patients with HLH. Method This study included adult patients with HLH admitted in West China Hospital of Sichuan University from January 2009 to June 2019. Patients with HLH were excluded from the study if they had a functioning kidney transplant, received renal replacement therapy (RRT) in the past month, suffered from end-stage renal disease (ESRD) or had the renal malignant tumor. The diagnosis of HLH was based on the HLH diagnostic criteria revised by the Histocyte Society in 2004 and AKI was defined according to the 2012 KDIGO (Kidney Disease: Improving Global Outcomes) guideline. We collected basic information, clinical manifestations and laboratory data of patients from electronic medical records. Results We analyzed 294 patients this time, of whom 95 (32.3%) developed AKI. The patients were divided into two groups according to the occurrence of AKI. The mortality rate in the AKI group was significantly higher than that in the non-AKI group (40.0% VS 12.6%; p & lt;0.001). The risk factors of AKI in patients with HLH were hyperphosphatemia [Odds Ratio (OR) 3.825; 95% Confidence Interval (CI) 1.647-8.886; p=0.002] ,heart failure (OR 2.972; 95% CI 1.029-8.584; p=0.044), increased heart rate (OR 1.025; 95% CI 1.008-1.043; p=0.004), prolonged prothrombin time (OR 1.025; 95% CI 1.001-1.049; p=0.041), elevated total bilirubin level (OR 1.003; 95% CI 1.000-1.007; p=0.030), and hypoproteinemia (OR 0.915; 95% CI 0.842-0.994; p=0.035). Conclusion The incidence of AKI in HLH patients is frequent, and the risk of death in HLH patients with AKI is significantly higher. The occurrence of AKI in patients with HLH is related to hyperphosphatemia, heart failure, increased heart rate, prolonged prothrombin time, elevated total bilirubin level, and hypoproteinemia.
    Type of Medium: Online Resource
    ISSN: 0931-0509 , 1460-2385
    URL: Article
    DOI: 10.1093/ndt/gfaa142.P0626
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1465709-0
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  • 7
    Online Resource
    Online Resource
    Lysosomal control of dendritic cell function
    Oxford University Press (OUP) ; 2023
    In:  Journal of Leukocyte Biology ( 2023-09-29)
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), ( 2023-09-29)
    Abstract: Lysosomal compartments undergo extensive remodeling during dendritic cell (DC) activation to meet the dynamic functional requirements of DCs. Instead of being regarded as stationary and digestive organelles, recent studies have increasingly appreciated the versatile roles of lysosomes in regulating key aspects of DC biology. Lysosomes actively control DC motility by linking calcium efflux to the actomyosin contraction, while enhanced DC lysosomal membrane permeability (LMP) contributes to the inflammasome activation. Besides, lysosomes provide a platform for the transduction of innate immune signaling and the intricate host-pathogen interplay. Lysosomes and lysosome-associated structures are also critically engaged in antigen presentation and cross-presentation processes, which are pivotal for the induction of antigen specific adaptive immune response. Through the current review, we emphasize that lysosome targeting strategies serve as vital DC based immunotherapies in fighting against tumor, infectious diseases and autoinflammatory disorders.
    Type of Medium: Online Resource
    ISSN: 1938-3673
    URL: Article
    DOI: 10.1093/jleuko/qiad117
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2026833-6
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  • 8
    Online Resource
    Online Resource
    MO412THE RISK FACTORS OF ACUTE KIDNEY INJURY CAUSED BY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
    Oxford University Press (OUP) ; 2021
    In:  Nephrology Dialysis Transplantation Vol. 36, No. Supplement_1 ( 2021-05-29)
    Details
    In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 36, No. Supplement_1 ( 2021-05-29)
    Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by overproduction of proinflammatory cytokines and hemophagocytosis. Acute kidney injury (AKI) is the most common complication of HLH in the kidney, which is a strong predictor of poor prognosis. In this retrospective study, we aimed to find the risk factors of AKI in patients with HLH. Method We screened all adult patients with HLH admitted to West China Hospital of Sichuan University from January 2009 to June 2019. Patients in this study were secondary HLH according to the HLH diagnostic criteria revised by the Histocyte Society in 2004. Patients with HLH were excluded from the study if they had a functioning kidney transplant, received renal replacement therapy (RRT) in the past month, suffered from end-stage renal disease (ESRD), or had the renal malignant tumor. We collected basic information, clinical manifestations, and laboratory data of patients from electronic medical records. Results A total of 600 patients with confirmed diagnosis of secondary HLH are included in our analysis. There are 199(33.2%)HLH-induced AKI patients, among whom 37.2%, 32.7%, and 30.2% are classified as AKI I, II, and III, respectively, according to the 2012 KDIGO (Kidney Disease: Improving Global Outcomes) guideline. Overall hospital mortality is 176(29.3%), and the number of deaths in patients with AKI was much higher than that in patients without AKI (53.3% versus 17.5%, P & lt; 0.001). The risk factors of AKI in patients with HLH were hyperphosphatemia (P & lt;0.001, OR 5.448, 95%CI 2.951-10.059) , vasopressor(P & lt;0.001, OR 3.485, 95%CI 2.114-5.746), heart failure (P=0.044, 0R 2.336, 95%CI 1.022-5.340), gastrointestinal symptoms (P=0.043, OR 1.877, 95%CI 1.021-3.453), increased heart rate (P=0.005, OR 1.017, 95%CI 1.005-1.029), elevated total bilirubin level(P & lt;0.001, OR 1.004, 95%CI 1.002-1.007), and hypoproteinemia (P=0.034, OR 0.939, 95%CI 0.886-0.995). Conclusion The incidence of AKI was higher in patients with HLH, and the risk of death was significantly higher in HLH patients with AKI. A variety of risk factors are related to the occurrence of HLH-induced AKI. Identifying and correcting them early in clinical diagnosis and treatment may reduce the incidence of AKI in patients with HLH and improve the prognosis of them.
    Type of Medium: Online Resource
    ISSN: 0931-0509 , 1460-2385
    URL: Article
    DOI: 10.1093/ndt/gfab083.004
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1465709-0
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  • 9
    Online Resource
    Online Resource
    Molecular mechanisms underlying human spatial cognitive ability revealed with neurotransmitter and transcriptomic mapping
    Oxford University Press (OUP) ; 2023
    In:  Cerebral Cortex ( 2023-10-06)
    Details
    In: Cerebral Cortex, Oxford University Press (OUP), ( 2023-10-06)
    Abstract: Mental rotation, one of the cores of spatial cognitive abilities, is closely associated with spatial processing and general intelligence. Although the brain underpinnings of mental rotation have been reported, the cellular and molecular mechanisms remain unexplored. Here, we used magnetic resonance imaging, a whole-brain spatial distribution atlas of 19 neurotransmitter receptors, transcriptomic data from Allen Human Brain Atlas, and mental rotation performances of 356 healthy individuals to identify the genetic/molecular foundation of mental rotation. We found significant associations of mental rotation performance with gray matter volume and fractional amplitude of low-frequency fluctuations in primary visual cortex, fusiform gyrus, primary sensory-motor cortex, and default mode network. Gray matter volume and fractional amplitude of low-frequency fluctuations in these brain areas also exhibited significant sex differences. Importantly, spatial correlation analyses were conducted between the spatial patterns of gray matter volume or fractional amplitude of low-frequency fluctuations with mental rotation and the spatial distribution patterns of neurotransmitter receptors and transcriptomic data, and identified the related genes and neurotransmitter receptors associated with mental rotation. These identified genes are localized on the X chromosome and are mainly involved in trans-synaptic signaling, transmembrane transport, and hormone response. Our findings provide initial evidence for the neural and molecular mechanisms underlying spatial cognitive ability.
    Type of Medium: Online Resource
    ISSN: 1047-3211 , 1460-2199
    URL: Article
    DOI: 10.1093/cercor/bhad368
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1483485-6
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Isolation of a Poterioochromonas capable of feeding on Microcystis aeruginosa and degrading microcystin-LR
    Oxford University Press (OUP) ; 2008
    In:  FEMS Microbiology Letters Vol. 288, No. 2 ( 2008-11), p. 241-246
    Details
    In: FEMS Microbiology Letters, Oxford University Press (OUP), Vol. 288, No. 2 ( 2008-11), p. 241-246
    Type of Medium: Online Resource
    ISSN: 0378-1097 , 1574-6968
    URL: Issue
    URL: Article
    DOI: 10.1111/fml.2008.288.issue-2
    DOI: 10.1111/j.1574-6968.2008.01355.x
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2008
    detail.hit.zdb_id: 1501716-3
    SSG: 12
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