In:
The Journal of Rheumatology, The Journal of Rheumatology, Vol. 42, No. 6 ( 2015-06), p. 943-947
Abstract:
To investigate the role of thrombospondin 1 (TSP-1) in RA. Methods. Expression of TSP-1 in synovial tissues was determined by immunohistochemistry. Expression of TSP-1 in rheumatoid fibroblast-like synovial cells (FLS) was investigated by quantitative real-time PCR and ELISA. Correlations among the plasma TSP-1 and other variables in patients with RA were examined. Results. Expression of TSP-1 was increased in rheumatoid synovial tissues. Transforming growth factor-β1 (TGF-β1) clearly increased TSP-1 expression in FLS on both mRNA and protein levels. Changes in plasma TSP-1 were associated with those in 28-joint Disease Activity Score-erythrocyte sedimentation rate and plasma TGF-β1. Conclusion. TSP-1 might be critically involved in the disease process of RA through the TGF-β1/TSP-1 axis.
Type of Medium:
Online Resource
ISSN:
0315-162X
,
1499-2752
DOI:
10.3899/jrheum.141292
Language:
English
Publisher:
The Journal of Rheumatology
Publication Date:
2015
Permalink