In:
Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 50, No. Suppl_1 ( 2019-02)
Abstract:
Introduction: Homocysteine is reportedly involved with direct endothelial damage that seems to cause vascular damage. Considering the racial differences in homocysteine levels and the atherosclerotic process in cerebral arteries, the impact of risk factors on stroke are likely different from those in Caucasians, however, to date, there are no Japanese cohort studies on the relationship between homocysteine levels and incidence of stroke. Therefore, we aimed to clarify the relationship between serum homocysteine levels and stroke risk in neurologically normal Japanese cohort. Materials and Methods: From January 2000 to December 2016, a total of 4,552 Japanese subjects voluntarily participated in a health checkup. Among the 4,552 subjects, the final analysis included 412 subjects (203 men and 209 women) aged 32-89 years (mean 65.1 ± 9.2) from whom we could obtain serum homocysteine levels and follow-up information with a mean interval of 7.6 years after the initial examination. The follow-up information about health conditions was obtained by annual mail inquiries. Homocysteine levels were categorized in quartiles of the baseline distribution, and the associations between the homocysteine level and demographics, vascular risk factors, asymptomatic lesions on MRI, cognitive functions, and incidence rates for stroke and all-cause of death were investigated. Results: After adjustment for the traditional cardiovascular risk factors, a higher homocysteine level was associated with silent brain infarctions [odds ratio for the highest vs the lowest quartile of homocysteine, 3.71 (95% confidence interval (CI): 1.04-13.2, P=0.04)] at baseline evaluation. During follow-up, there were 13 documented cases of stroke and 16 all-cause cases of deaths. In a Cox hazard model, homocysteine levels were significantly associated with incidence of stroke when fully adjusted for traditional cardiovascular risk factors. Participants with a higher homocysteine level had a 10.7-fold increased risk for stroke (95% CI, 1.09-104.1, P=0.04); however, there was no association between homocysteine levels and all-cause death. Conclusions: High serum homocysteine level was significantly associated with silent brain infarctions and incidence of stroke in Japanese.
Type of Medium:
Online Resource
ISSN:
0039-2499
,
1524-4628
DOI:
10.1161/str.50.suppl_1.WP231
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2019
detail.hit.zdb_id:
1467823-8
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