In:
FEBS Letters, Wiley, Vol. 504, No. 1-2 ( 2001-08-24), p. 73-77
Kurzfassung:
Treatment of Chinese hamster ovary K1 cells with phosphatidylserine (PS) caused typical apoptosis with distinct morphological and biochemical features in a dose‐ and time‐dependent manner. However, unlike camptothecin‐induced apoptosis, changes in mitochondrial transmembrane potential were not observed. In addition, cytochrome c release did not occur in PS‐induced apoptosis. A pan caspase inhibitor, Z‐VAD, significantly inhibited the apoptosis, but inhibitors of caspase‐1, ‐3, ‐8 and ‐9 did not. Activities of caspase‐1, ‐3, ‐8 and ‐9 were increased by treatment of the cells with camptothecin, but not with PS. These results suggest that PS‐induced apoptosis occurs without the collapse of mitochondrial transmembrane potential and without the release of cytochrome c , in a manner independent of caspase‐1, ‐3, ‐8 and ‐9.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(01)02771-5
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2001
ZDB Id:
212746-5
ZDB Id:
1460391-3
SSG:
12
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