In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 11 ( 2022-11-4), p. e0275832-
Kurzfassung:
Studies from Asia, Europe and the USA indicate that widely available haematological parameters could be used to determine the clinical severity of Coronavirus disease 2019 (COVID-19) and predict management outcome. There is limited data from Africa on their usefulness in patients admitted to Intensive Care Units (ICUs). We performed an evaluation of baseline haematological parameters as prognostic biomarkers in ICU COVID-19 patients. Methods Demographic, clinical and laboratory data were collected prospectively on patients with confirmed COVID-19, admitted to the adult ICU in a tertiary hospital in Cape Town, South Africa, between March 2020 and February 2021. Robust Poisson regression methods and receiver operating characteristic (ROC) curves were used to explore the association of haematological parameters with COVID-19 severity and mortality. Results A total of 490 patients (median age 54.1 years) were included, of whom 237 (48%) were female. The median duration of ICU stay was 6 days and 309/490 (63%) patients died. Raised neutrophil count and neutrophil/lymphocyte ratio (NLR) were associated with worse outcome. Independent risk factors associated with mortality were age (ARR 1.01, 95%CI 1.0–1.02; p = 0.002); female sex (ARR 1.23, 95%CI 1.05–1.42; p = 0.008) and D-dimer levels (ARR 1.01, 95%CI 1.002–1.03; p = 0.016). Conclusions Our study showed that raised neutrophil count, NLR and D-dimer at the time of ICU admission were associated with higher mortality. Contrary to what has previously been reported, our study revealed females admitted to the ICU had a higher risk of mortality.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0275832
DOI:
10.1371/journal.pone.0275832.g001
DOI:
10.1371/journal.pone.0275832.g002
DOI:
10.1371/journal.pone.0275832.g003
DOI:
10.1371/journal.pone.0275832.t001
DOI:
10.1371/journal.pone.0275832.t002
DOI:
10.1371/journal.pone.0275832.t003
DOI:
10.1371/journal.pone.0275832.t004
DOI:
10.1371/journal.pone.0275832.s001
DOI:
10.1371/journal.pone.0275832.s002
DOI:
10.1371/journal.pone.0275832.s003
DOI:
10.1371/journal.pone.0275832.s004
DOI:
10.1371/journal.pone.0275832.r001
DOI:
10.1371/journal.pone.0275832.r002
DOI:
10.1371/journal.pone.0275832.r003
DOI:
10.1371/journal.pone.0275832.r004
DOI:
10.1371/journal.pone.0275832.r005
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2022
ZDB Id:
2267670-3
Permalink