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  • Frontiers Media SA  (4)
  • Xu, Hong  (4)
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  • Frontiers Media SA  (4)
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  • 1
    Online Resource
    Online Resource
    Table_1.docx
    Frontiers Media SA ; 2023
    In:  Frontiers in Oncology Vol. 13 ( 2023-8-11)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 13 ( 2023-8-11)
    Abstract: This study aimed to provide a realistic observation of survival by major site for 48,866 cancer patients treated at a tertiary cancer hospital in a rural area of China. Methods Patients with cancer registered between 2007 and 2017 in the Nantong rural area were followed up. The starting date for survival calculation was the date of the first diagnosis of cancer at the Nantong Tumor Hospital, and the closing date was December 31, 2020. Observed survival (OS) was analyzed according to ICD-10 site, sex, age, region, and hospitalization period using the life table method and compared using the Wilcoxon (Gehan) statistic. Results The overall 5-year OS rate was 40.48% for all 48,866 patients, 30.19% for males, and 51.90% for females. The top five cancer sites, accounting for 60.51% of the total cases, were the esophagus, lung, stomach, liver, and cervix, with 5-year OS rates of 33.72%, 18.64%, 32.10%, 19.04%, and 71.51%, respectively. The highest 5-year OS was observed in the thyroid (87.52%) and the lowest was in the pancreas (6.37%). Survival was significantly higher in younger patients than in older patients, with 5-year OSs of 69.26% and 19.84% in those aged 20-29 and 90-99 years, respectively. Five-year OSs improved significantly from 39.35% in 2007-2011 to 41.26% in 2012-2017. Conclusion Overall survival improved over the years, although the improvement at some sites was not significant. The observed survival varies from region to region, reflecting differences in the patterns of major sites, disparities in proportions of hospitalization, and demographic characteristics.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2023.1244545
    DOI: 10.3389/fonc.2023.1244545.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2649216-7
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Table6.XLSX
    Frontiers Media SA ; 2023
    In:  Frontiers in Earth Science Vol. 11 ( 2023-3-22)
    Details
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 11 ( 2023-3-22)
    Abstract: It is very important to improve the design of supports because the cut and cover method of layered backfill after construction is the primary method used to construct shallow buried sections of mountain tunnels. The Dujuan Valley Tunnel in Fenghua City is the subject of this research. First, a geometric model of a shallow buried section of a mountain tunnel and its construction parameters were used to develop the simplified bearing capacity analysis model for the covered arch. Second, a simplified method to calculate the internal force of the cover arch supporting structure was established by using the method of structural mechanics. Thus, a method was established to determine the safe thickness of the cover arch and to analyze the bearing capacity and stability of the enlarged foundation of the arch foot. Third, the influence of the tunnel burial depth, cap arch sag height, central angle, radius and arch foot width on the bearing characteristics of the cover arch support structure was discussed, and the optimal design principle of excavation in shallow buried sections of mountain tunnels was obtained. Finally, the calculation and evaluation of the design in an example case were used to determine the rationality of the method to design and optimize shallow buried sections of mountain tunnels with the cut and cover method.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/feart.2023.1092928
    DOI: 10.3389/feart.2023.1092928.s001
    DOI: 10.3389/feart.2023.1092928.s002
    DOI: 10.3389/feart.2023.1092928.s003
    DOI: 10.3389/feart.2023.1092928.s004
    DOI: 10.3389/feart.2023.1092928.s005
    DOI: 10.3389/feart.2023.1092928.s006
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2741235-0
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  • 3
    Online Resource
    Online Resource
    DataSheet2.pdf
    Frontiers Media SA ; 2022
    In:  Frontiers in Chemistry Vol. 10 ( 2022-7-18)
    Details
    In: Frontiers in Chemistry, Frontiers Media SA, Vol. 10 ( 2022-7-18)
    Abstract: We have designed and synthesized a novel simple colorimetric fluorescent probe with aggregation-induced emission (AIE) properties. Probe 5-(4-(diphenylamine)phenyl) thiophen-2-formaldehyde W exhibited a turn-on fluorescent response to cyanide ion (CN − ), which induces distinct visual color changes. Probe W exhibited a highly selective and sensitive ratiometric fluorescence response for the detection of CN − over a wide pH range (4–11) and in the presence of common interferents. The linear detection of CN − over the concentration range of 4.00–38.00 µM ( R 2 = 0.9916, RSD = 0.02) was monitored by UV-Vis absorption spectrometry (UV-Vis) with the limit of detection determined to be 0.48 µM. The linear detection of CN − over the concentration range of 8.00–38.00 µM was examined by fluorescence spectrophotometry ( R 2 = 0.99086, RSD = 0.031), and the detection limit was found to be 68.00 nM. The sensing mechanisms were confirmed by 1 H NMR spectroscopic titrations, X-ray crystallographic analysis, and HRMS. Importantly, probe W was found to show rapid response, high selectivity, and sensitivity for cyanide anions in real water samples, over the range of 100.17∼100.86% in artificial lake water and 100.54∼101.64% in running water by UV-Vis absorption spectrometry, and over the range of 99.42∼100.71% in artificial lake water and 100.59∼101.17% in running water by fluorescence spectrophotometry. Importantly, this work provides a simple and effective approach which uses an economically cheap and uncomplicated synthetic route for the selective, sensitive, and quantitative detection of CN − ions in systems relevant to the environment and health.
    Type of Medium: Online Resource
    ISSN: 2296-2646
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fchem.2022.923149
    DOI: 10.3389/fchem.2022.923149.s001
    DOI: 10.3389/fchem.2022.923149.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711776-5
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Electroacupuncture ameliorates inflammatory response induced by retinal ischemia-reperfusion injury and protects the retina through the DOR-BDNF/Trkb pathway
    Frontiers Media SA ; 2023
    In:  Frontiers in Neuroanatomy Vol. 16 ( 2023-1-5)
    Details
    In: Frontiers in Neuroanatomy, Frontiers Media SA, Vol. 16 ( 2023-1-5)
    Abstract: Objectives: Retinal ischemia-reperfusion injury (RIRI) is the common pathological basis of many ophthalmic diseases in the later stages, and inflammation is the primary damage mechanism of RIRI. Our study aimed to assess whether electroacupuncture (EA) has a protective effect against RIRI and to elucidate its related mechanisms. Methods: A high-intraocular pressure (HIOP) model was used to simulate RIRI in Wistar rats. EA was applied to the EA1 group [Jingming (BL1) + Shuigou (GV26)] and the EA2 group [Jingming (BL1) + Hegu (LI4)] respectively for 30 min starting immediately after the onset of reperfusion and repeated (30 min/time) at 12 h and then every 24 h until days 7 after reperfusion. The pathological changes in the retina were observed by H and E staining after HIOP. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was utilized to observe retinal cell apoptosis. The mRNA expression of IL1-β, TNF-α, IL-4, IL-10, δ-opioid receptor (DOR), brain-derived neurotrophic factor (BDNF), and tropomyosin-related kinase B (TrkB) in the retina was measured by quantitative real-time PCR. Results: HIOP caused structural disorders of the retina, decreased RGCs, and increased retinal cell apoptosis. At 1 and 3 days of RIRI, retinal apoptotic cells in the EA group were significantly reduced, while there was no distinct difference in the EA group compared with the HIOP group at 7 days of RIRI. Compared with that in the HIOP group, the expression of anti-inflammatory factors, DOR and TrkB was increased, and the expression of pro-inflammatory factors was decreased in the EA group. In contrast, HIOP had no appreciable effect on BDNF expression. Conclusion: EA at Jingming (BL1) and Shuigou (GV26) or at Jingming (BL1) and Hegu (LI4) may inhibit RIRI induced inflammation through activating the DOR-BDNF/TrkB pathway to protect the retina, especially the pair of Jingming (BL1) and Shuigou (GV26) has better inhibitory effects on inflammation.
    Type of Medium: Online Resource
    ISSN: 1662-5129
    URL: Article
    DOI: 10.3389/fnana.2022.1057929
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2452969-2
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