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  • Hindawi Limited  (54)
  • Xu, Hao  (54)
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  • Hindawi Limited  (54)
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  • 1
    Online Resource
    Online Resource
    Effect of adjuvant drug therapy after varicocelectomy on fertility outcome in males with varicocele-associated infertility: Systematic review and meta-analysis
    Hindawi Limited ; 2018
    In:  Andrologia Vol. 50, No. 8 ( 2018-10), p. e13070-
    Details
    In: Andrologia, Hindawi Limited, Vol. 50, No. 8 ( 2018-10), p. e13070-
    Type of Medium: Online Resource
    ISSN: 0303-4569
    URL: Issue
    URL: Article
    DOI: 10.1111/and.2018.50.issue-8
    DOI: 10.1111/and.13070
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2009045-6
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  • 2
    Online Resource
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    Identification of a Novel Metastasis-Related miRNAs-Based Signature for Predicting the Prognosis of Hepatocellular Carcinoma
    Hindawi Limited ; 2021
    In:  Journal of Oncology Vol. 2021 ( 2021-1-31), p. 1-14
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2021 ( 2021-1-31), p. 1-14
    Abstract: Hepatocellular carcinoma (HCC) is one of the most common internal malignancies worldwide and is associated with a poor prognosis. Abnormal expression of miRNAs is believed to play a role in the recurrent metastasis of HCC. However, limited studies on the role of miRNAs in HCC metastasis have been carried out. Therefore, this study is aimed at exploring the potential value of metastasis-related miRNAs (MRMs) in HCC. We retrieved MRMs were from the Human Cancer Metastasis Database. Differential miRNAs were identified for tumor samples of HCC patients and normal samples based on the TCGA database. Further, univariate and multivariate Cox regression analyses were used to screen MRMs known to be independent prognostic factors in HCC. These MRMs were then used to build a prognostic signature. All patients were classified into high-risk and low-risk groups based on the median of the signature scores. Moreover, GO and KEGG pathway enrichment analyses were performed to predict the function of these MRMs. Finally, a nomogram was constructed to predict the OS of patients at 1, 2, and 3 years. In our study, a total of seven prognostic MRMs (miR-140-3p, miR-9-5p, miR-942-5p, miR-324-3p, miR-29c-5p, miR-551a, and miR-149-5p) were identified and used for constructing the prognostic signature based on the training cohort. Patients in the low-risk HCC group showed better overall survival (OS) than those in the high-risk group. The results were validated using the validation cohort. In summary, the findings of this study provide evidence that MRMs-based prognostic signature is an independent biomarker in the prognosis of HCC patients.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2021/6629633
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2461349-6
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  • 3
    Online Resource
    Online Resource
    Randomized, Double-Blinded, Multicenter, Placebo-Controlled Trial of Shenfu Injection for Treatment of Patients with Chronic Heart Failure during the Acute Phase of Symptom Aggravation (Yang and Qi Deficiency Syndrome)
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-02-25), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-02-25), p. 1-8
    Abstract: Background . Shenfu injection (SFI) has shown a remarkable therapeutic effect in patients with chronic heart failure (CHF) during the acute phase of symptom aggravation since it became commercially available in 1987. However, the therapeutic effect of SFI has not been validated in a standard clinical study. As a pilot clinical trial, this study aimed to evaluate the safety and efficacy of SFI for treatment of CHF patients during the acute phase. Methods . A total of 160 patients experiencing acute phase CHF were enrolled in this study and randomly assigned to receive the placebo (placebo group, 150 ml glucose (GS)) or SFI (SFI group, 50 ml SFI + 100 ml GS) in addition to their standard medications for CHF treatment. The treatment lasted for 7 ± 1 days, and the follow-up continued for 28 ± 3 days after treatment. The primary endpoints were New York Heart Association (NYHA) classification and Traditional Chinese Medicine (TCM) syndrome scores. Results . After 7±1 days of treatment, the efficacy of SFI according to improvements in NYHA and TCM syndrome scores in the SFI group (78.38% and 89.19%, respectively) was significantly higher than that in the placebo group (61.43% and 60.00%, respectively; P 〈 0.05). The SFI group had a longer increase in amplitude than the placebo group (113.00 m versus 82.99 m, P 〈 0.05). The incidence of adverse events and other safety indices showed no significant differences between the two groups. Conclusion . SFI combined with conventional therapy for treatment of CHF during acute symptom aggravation ameliorated the cardiac dysfunction and clinical symptoms and improved the patients’ quality of life without any significant AEs compared with the conventional therapy alone.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/9297163
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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  • 4
    Online Resource
    Online Resource
    Removal of Matrix Interferences by Nano-MgO and Co-Adsorbents for Accurate Multi-Pesticide Residue Analysis in the Chinese Medicinal Herb, Paeoniae Radix Alba
    Hindawi Limited ; 2021
    In:  Journal of Analytical Methods in Chemistry Vol. 2021 ( 2021-2-4), p. 1-10
    Details
    In: Journal of Analytical Methods in Chemistry, Hindawi Limited, Vol. 2021 ( 2021-2-4), p. 1-10
    Abstract: A simple, accurate, and high-throughput analytical method was developed to detect 123 pesticide residues in Chinese medicinal herb Paeoniae Radix Alba (PRA) by introducing nano-MgO as a highly efficient purification material based on quick, easy, cheap, effective, rugged, and safe (QuEChERS) design concept. Various PRA samples were extracted using 8 mL 0.5% acetic acid-acetonitrile solution and purified by a dispersive solid-phase extraction method with 30 mg nano-MgO, 40 mg primary secondary amine (PSA), and 40 mg octadecylsilane (C18) as the cleanup adsorbents, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). 70.7% of pesticides showed a weak matrix effect after the purification process, indicating that this method can give the precise quantitative analysis of trace pesticides residue. The method was systematically validated under optimal conditions in five different kinds of PRA samples; good linearity was observed in the concentration range of 0.5–250 μg/L or 1–250 μg/L. Pesticide recovery in each sample spiked at concentrations of 20, 50, and 200 μg/kg ranged from 98.0% to 111% and the mean relative standard deviation ranged from 2.72% to 5.70%. Furthermore, the method comparison with the traditional QuEChERS method suggested the feasibility, advantages, and potential application prospect of the present method for the multi-pesticide residue analysis in various PRA samples.
    Type of Medium: Online Resource
    ISSN: 2090-8873 , 2090-8865
    URL: Article
    DOI: 10.1155/2021/6626257
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2654178-6
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  • 5
    Online Resource
    Online Resource
    Combination of Chinese Herbal Medicines and Conventional Treatment versus Conventional Treatment Alone in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention (5C Trial): An Open-Label Randomized Controlled, Multicenter Study
    Hindawi Limited ; 2013
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2013 ( 2013), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
    Abstract: Aims. To evaluate the efficacy of Chinese herbal medicines (CHMs) plus conventional treatment in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods and Results. Participants ( n = 808 ) with ACS who underwent PCI from thirteen hospitals of mainland China were randomized into two groups: CHMs plus conventional treatment group (treatment group) or conventional treatment alone group (control group). All participants received conventional treatment, and participants in treatment group additionally received CHMs for six months. The primary endpoint was the composite of cardiac death, nonfatal recurrent MI, and ischemia-driven revascularization. Secondary endpoint was the composite of readmission for ACS, stroke, or congestive heart failure. The safety endpoint involved occurrence of major bleeding events. The incidence of primary endpoint was 2.7% in treatment group versus 6.2% in control group (HR, 0.43; 95% CI, 0.21 to 0.87; P = 0.015 ). The incidence of secondary endpoint was 3.5% in treatment group versus 8.7% in control group (HR, 0.39; 95% CI, 0.21 to 0.72; P = 0.002 ). No major bleeding events were observed in any participant. Conclusion. Treatment with CHMs plus conventional treatment further reduced the occurrence of cardiovascular events in patients with ACS after PCI without increasing risk of major bleeding.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2013/741518
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2148302-4
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  • 6
    Online Resource
    Online Resource
    On-Chip Embedded Debugging System Based on Leach Algorithm Parameter on Detection of Wireless Sensor Networks
    Hindawi Limited ; 2020
    In:  Mathematical Problems in Engineering Vol. 2020 ( 2020-09-07), p. 1-7
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2020 ( 2020-09-07), p. 1-7
    Abstract: Leach (low energy adaptive clustering hierarchy) algorithm is a self-clustering topology algorithm. Its execution process is cyclical. Each cycle is divided into two phases: cluster building phase and stable data communication phase. In the stage of cluster building, the adjacent nodes cluster dynamically and randomly generate cluster heads. In the data communication phase, the nodes in the cluster send the data to the cluster head, and the cluster head performs data fusion and sends the results to the aggregation node. Because the cluster head needs to complete data fusion, communication with the convergence node and other works, the energy consumption is large. Leach algorithm can ensure that each node acts as cluster head with equal probability, so that the nodes in the network consume energy relatively evenly. The basic idea of Leach algorithm is to randomly select cluster head nodes in a circular way. It evenly distributes the energy load of the whole network to each sensor node in the network. It can reduce network energy consumption and improve network life cycle. Leach repeatedly performs cluster refactoring during its operation. This paper studies the parameter detection of wireless sensor network based on Leach algorithm on the on-chip embedded debugging system. Because the classical low-power adaptive clustering layered protocol (Leach) has the problem of energy imbalance and short node life cycle, this paper uses embedded debugging technology based on Leach algorithm and the residual energy and position of nodes in wireless sensor networks were tested for research. This Leach algorithm uses the concept of wheel. Each round consists of two phases: initialization and stabilization. In the initialization stage, each node generates a random number between 0 and 1. If the random number generated by a node is less than the set threshold T (n), the node publishes a message that it is a cluster head. Through the research on the parameter detection, the simulation results show that the research in this paper has good feasibility and rationality.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2020/7249674
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 7
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    Identification of snoRNA SNORA71A as a Novel Biomarker in Prognosis of Hepatocellular Carcinoma
    Hindawi Limited ; 2020
    In:  Disease Markers Vol. 2020 ( 2020-09-27), p. 1-7
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2020 ( 2020-09-27), p. 1-7
    Abstract: Background . Small nucleolar RNAs (snoRNAs) have been proved to play important roles in various cellular physiological process. Recently, dysregulation of snoRNA SNORA71A has been found involved in tumorigenesis of various malignant cancers. However, the emerging effects of SNORA71A in hepatocellular carcinoma (HCC) remain largely unclear. In this study, we aimed to explore the SNORA71A expression and its underlying significance in HCC. Methods . Expression of SNORA71A in cell lines and clinical specimens was measured by quantitative real-time PCR. Then, all enrolled HCC patients were divided into low and high SNORA71A expression subgroups and then they were compared in the aspects of clinical features as well as survival outcome by respective statistical analysis methods. Results . SNORA71A was significantly downexpressed in SK-HEP-1 ( P = 0.001 ), Huh-7 ( P 〈 0.001 ), Hep3B ( P 〈 0.001 ), and clinical HCC specimens ( P = 0.006 ). Comparing the clinical features between SNORA71A expression subgroups, it showed that low SNORA71A expression was significantly associated with large tumor diameter, multiple lesions, capsular invasion, bad tumor differentiation, and TNM stage ( P 〈 0.05 ). Furthermore, it was found that HCC patients with lower SNORA71A expression had higher risk in postoperative tumor relapse (median time: 9.5 vs. 35.2 months; low vs. high; P 〈 0.001 ) and poor overall survival (median time: 36.8 vs. 52.9 months; low vs. high; P 〈 0.001 ). Besides, SNORA71A expression served as independent risk factors for tumor-free ( HR = 0.450 ; 95% CI [0.263-0.770]; P = 0.004 ) and long-term survival ( HR = 0.289 ; 95% CI [0.127-0.657]; P = 0.003 ). Conclusions . Our study for the first time demonstrated that downregulation of SNORA71A could serve as a novel biomarker for clinical assessment and prognostic prediction of HCC patients.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2020/8879944
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2033253-1
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  • 8
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    Downregulation of snoRNA SNORA52 and Its Clinical Significance in Hepatocellular Carcinoma
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-6-3), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-6-3), p. 1-7
    Abstract: Hepatocellular carcinoma (HCC) is one of the most common and aggressive tumors in the world while the accuracy of the present tests for detecting HCC is poor. A novel diagnostic and prognostic biomarker for HCC is urgently needed. Overwhelming evidence has demonstrated the regulatory roles of small nucleolar RNA (snoRNA) in carcinogenesis. This study is aimed at analyzing the expression of a snoRNA, SNORA52, in HCC and exploring the correlation between its expression and various clinical characteristics of HCC patients. By using quantitative real-time PCR, we found that SNORA52 was downregulated in HCC cell lines ( P 〈 0.05 ) and HCC tissues ( P 〈 0.001 ). Correlation analysis showed that the expression of SNORA52 was obviously associated with tumor size ( P = 0.011 ), lesion number ( P = 0.007 ), capsular invasion ( P = 0.011 ), tumor differentiation degree ( P = 0.046 ), and TNM stage ( P = 0.004 ). The disease-free survival (DFS) and overall survival (OS) analysis showed that patients with lower SNORA52 expression had a worse prognosis ( P 〈 0.001 ). Univariate and multivariate Cox regression analysis showed that SNORA52 expression was a completely independent prognostic factor to predict DFS ( P = 0.009 ) and OS ( P = 0.012 ) of HCC patients. Overall, our findings showed SNORA52 expression levels were downregulated in HCC tissues and correlated with multiple clinical variables, and SNORA52 was an independent prognostic factor for HCC patients, which suggested that SNORA52 could function as a potential diagnostic and prognostic biomarker for HCC patients.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/7020637
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
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  • 9
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    Preparation of a New Borehole Sealing Material of Coal Seam Water Infusion
    Hindawi Limited ; 2018
    In:  Advances in Materials Science and Engineering Vol. 2018 ( 2018), p. 1-7
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2018 ( 2018), p. 1-7
    Abstract: To improve the borehole sealing effect of coal seam water infusion, especially that of coal seam with low permeability and high rigidity, this study investigated the performance test optimization of two cement-based sealing materials. The borehole sealing effect of this coal seam requires high-pressure water infusion. Result shows that when the water-cement ratio is 0.4 and the amount of fiber expansive agent is 10%, the new borehole sealing material displays microexpansion. In addition, the 1-day compressive strength reaches 16 MPa. This result satisfies the material compressive strength requirement under 30 MPa high-pressure water infusion. The sealing performance is also excellent. According to the scanning electron microscopy analysis of new borehole and traditional borehole sealing materials, the surface of new borehole sealing material shows no holes and possesses compactness. The sealing effect is superior to that of other traditional sealing materials. This effect can satisfy the sealing requirement of coal seam water infusion. The new borehole sealing material is considerably significant for the improvement of the water infusion effect.
    Type of Medium: Online Resource
    ISSN: 1687-8434 , 1687-8442
    URL: Article
    DOI: 10.1155/2018/5924614
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2501025-6
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  • 10
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    Chinese Herbal Medicines Might Improve the Long-Term Clinical Outcomes in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention: Results of a Decision-Analytic Markov Model
    Hindawi Limited ; 2015
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2015 ( 2015), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-9
    Abstract: Aims . The priority of Chinese herbal medicines (CHMs) plus conventional treatment over conventional treatment alone for acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) was documented in the 5C trial (chictr.org number: ChiCTR-TRC-07000021 ). The study was designed to evaluate the 10-year effectiveness of CHMs plus conventional treatment versus conventional treatment alone with decision-analytic model for ACS after PCI. Methods and Results . We constructed a decision-analytic Markov model to compare additional CHMs for 6 months plus conventional treatment versus conventional treatment alone for ACS patients after PCI. Sources of data came from 5C trial and published reports. Outcomes were expressed in terms of quality-adjusted life years (QALYs). Sensitivity analyses were performed to test the robustness of the model. The model predicted that over the 10-year horizon the survival probability was 77.49% in patients with CHMs plus conventional treatment versus 77.29% in patients with conventional treatment alone. In combination with conventional treatment, 6-month CHMs might be associated with a gained 0.20% survival probability and 0.111 accumulated QALYs, respectively. Conclusions . The model suggested that treatment with CHMs, as an adjunctive therapy, in combination with conventional treatment for 6 months might improve the long-term clinical outcome in ACS patients after PCI.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2015/639267
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2148302-4
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