GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Hindawi Limited  (2,204)
Material
Publisher
  • Hindawi Limited  (2,204)
Person/Organisation
Language
Years
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Epigenome-Wide Association Study Reveals Differential Methylation Sites and Association of Gene Expression Regulation with Ischemic Moyamoya Disease in Adults
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-3-24), p. 1-13
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-3-24), p. 1-13
    Abstract: Background. The association of DNA methylation with the pathogenesis of adult ischemic moyamoya disease (MMD) is unknown. Here, we investigated the genome-wide DNA methylation profiles in patients with MMD and identified the genes related to the pathogenesis of MMD. Methods. Whole blood samples were collected from 20 individuals, including 10 patients with ischemic moyamoya disease without any underlying disease and 10 healthy individuals. Genome-wide DNA methylation analysis was performed using Illumina 850K microarrays. Transcriptional correlation was verified using quantitative reverse transcription-polymerase chain reaction. In vitro experiments were used to analyze the association of functional defects with candidate epigenetic markers. Results. The genome-wide methylation level in the whole blood of adults with ischemic MMD was higher than that in the healthy individuals. In total, 759 methylation probes differed significantly between the case and control. The hypermethylated regions were mostly concentrated in the gene spacer regions. Among genes with the highest degree of the differential expression, KCNMA1 and GALNT2 were upregulated, whereas SOX6 and RBM33 were downregulated. Conclusions. This is the first study showing that the low expression of genes associated with epigenetic regulation, such as SOX6 and RBM33, may be related to vascular occlusion in MMD, whereas the overexpression of KCNMA1 and GALNT2 may be related to the vascular hyperplasia. The results suggest that DNA methylation was involved in the pathogenesis of MMD, and new pathogenic genes were proposed as biological markers.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/7192060
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Association of Uric Acid in Serum and Urine with Arterial Stiffness: Hanzhong Adolescent Hypertension Study
    Hindawi Limited ; 2020
    In:  Disease Markers Vol. 2020 ( 2020-07-17), p. 1-8
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2020 ( 2020-07-17), p. 1-8
    Abstract: Background . Hyperuricemia has long been associated with increased cardiovascular risk, and arterial stiffness is proposed as a mediator. The present study is aimed at examining the associations of uric acid (UA) in blood and urine with arterial stiffness in a Chinese cohort. Methods . A total of 2296 participants (mean age: 43.0 years) from our previously established cohort of Hanzhong Adolescent Hypertension Study were included. The participants were classified as subjects with or without arterial stiffness, which was defined as brachial-ankle pulse wave velocity baPWV ≥ 1400   cm / s and/or carotid intima-media thickness CIMT ≥ 0.9   mm . Multivariate regression analyses were used to examine the relationship between serum and urinary UA and the risk of arterial stiffness after adjusting for age, gender, systolic blood pressure, fasting glucose, BMI, heart rate, total cholesterol, and triglycerides. Results . baPWV was positively correlated with urinary uric acid/creatinine ratio (uUA/Cre) ( β = 0.061 , P 〈 0.001 ), while CIMT was correlated with uUA/Cre ( β = 0.085 , P 〈 0.001 ) and fractional excretion of uric acid (FEUA) ( β = 0.044 , P = 0.033 ) in all subjects. In addition, uUA/Cre was significantly associated with the risk of high baPWV [1.032 (1.019-1.045)] and arterial stiffness [1.028 (1.016-1.040)] . Conclusion . Our study showed that urinary UA excretion was significantly associated with the risk of arterial stiffness in Chinese adults. These findings suggest that UA, especially urinary UA, may be used as a simple, noninvasive marker for early detection of arterial stiffness in otherwise healthy subjects.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2020/1638515
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2033253-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Model Optimization of Shale Gas Reservoir Volume Fracturing Dissolved Gas Simulation Adsorbed Gas
    Hindawi Limited ; 2021
    In:  Geofluids Vol. 2021 ( 2021-2-18), p. 1-15
    Details
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-2-18), p. 1-15
    Abstract: Shale reservoirs have some natural fractures with a certain density and connectivity. The basic percolation model of shale gas reservoir: the black oil model of gas-water phase is used as the basic model, and the dissolved gas is used to simulate adsorbed gas. Accurate description of natural fractures: random distributed discrete fracture model is used as the basic model to describe natural fractures. By comparing the calculation results of single medium (including random distributed discrete fracture model) and double medium model, the model for predicting shale gas productivity is optimized.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2021/6631994
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer’s Disease via Intranasal Administration
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-1-25), p. 1-16
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-1-25), p. 1-16
    Abstract: Osthole (OST) is a natural coumarin compound that exerts multiple pharmacologic effects. However, the poor water solubility and the low oral absorption of OST limit its clinical application for the treatment of neurologic diseases. A suitable preparation needs to be tailored to evade these unfavourable properties of OST. In this study, an OST nanoemulsion (OST-NE) was fabricated according to the pseudoternary phase diagram method, which was generally used to optimize the prescription in light of the solubility of OST in surfactants and cosurfactants. The final composition of OST-NE was 3.6% of ethyl oleate as oil phase, 11.4% of the surfactant (polyethylene glycol ester of 15-hydroxystearic acid: polyoxyethylene 35 castor oil = 1 : 1 ), 3% of polyethylene glycol 400 as cosurfactant, and 82% of the aqueous phase. The pharmacokinetic study of OST-NE showed that the brain-targeting coefficient of OST was larger by the nasal route than that by the intravenous route. Moreover, OST-NE inhibited cell death, decreased the apoptosis-related proteins (Bax and caspase-3), and enhanced the activity of antioxidant enzymes (superoxide dismutase and glutathione) in L-glutamate-induced SH-SY5Y cells. OST-NE improved the spatial memory ability, increased the acetylcholine content in the cerebral cortex, and decreased the activity of acetylcholinesterase in the hippocampus of Alzheimer’s disease model mice. In conclusion, this study indicates that the bioavailability of OST was improved by using the OST-NE via the nasal route. A low dose of OST-NE maintained the neuroprotective effects of OST, such as inhibiting apoptosis and oxidative stress and regulating the cholinergic system. Therefore, OST-NE can be used as a possible alternative to improve its bioavailability in the prevention and treatment of Alzheimer’s disease.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/8844455
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Effect of adjuvant drug therapy after varicocelectomy on fertility outcome in males with varicocele-associated infertility: Systematic review and meta-analysis
    Hindawi Limited ; 2018
    In:  Andrologia Vol. 50, No. 8 ( 2018-10), p. e13070-
    Details
    In: Andrologia, Hindawi Limited, Vol. 50, No. 8 ( 2018-10), p. e13070-
    Type of Medium: Online Resource
    ISSN: 0303-4569
    URL: Issue
    URL: Article
    DOI: 10.1111/and.2018.50.issue-8
    DOI: 10.1111/and.13070
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2009045-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Recognition of Electromagnetic Signals Based on the Spiking Convolutional Neural Network
    Hindawi Limited ; 2022
    In:  Wireless Communications and Mobile Computing Vol. 2022 ( 2022-6-24), p. 1-9
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2022 ( 2022-6-24), p. 1-9
    Abstract: Feature extraction and recognition of signals are the bases of a cognitive radio. Traditional manual extraction for signals’ features becomes difficult in the complex electromagnetic environment. Although convolutional neural networks (CNNs) can extract signal features automatically, they have low accuracy in recognizing electromagnetic signals at low signal-to-noise ratios (SNRs) due to the agility of signals. Considering the great potential of spiking neural networks (SNNs) in classification, a spiking convolution neural network (SCNN) for the recognition of electromagnetic signals is proposed in this paper. The SCNN effectively integrates the extraction ability of spatial features in CNNs and temporal features in SNNs. Since the SCNN is difficult to train, the strategy of surrogate gradient is proposed to train it. By taking the 2-dimensional time-frequency distribution of 6 signals as input, the SCNN can effectively identify different signals at low SNRs. The method proposed in this paper contributes to promote the research and application of SNNs in the recognition of electromagnetic signals.
    Type of Medium: Online Resource
    ISSN: 1530-8677 , 1530-8669
    URL: Article
    DOI: 10.1155/2022/2395996
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2045240-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Securing Topology Control in SDWSNs Using Identity-Based Cryptography
    Hindawi Limited ; 2023
    In:  Journal of Sensors Vol. 2023 ( 2023-7-19), p. 1-20
    Details
    In: Journal of Sensors, Hindawi Limited, Vol. 2023 ( 2023-7-19), p. 1-20
    Abstract: In software-defined wireless sensor networks (SDWSNs), topology control is a fundamental procedure to maintain the global network topology. However, the open wireless channels of SDWSNs make it possible for an attacker to eavesdrop, replay, or modify the topology messages, thus posing a great threat to the network operations. The security of SDWSN topology control has not received enough attention yet. Identity-based cryptography (IBC) may be fitter for SDWSNs due to its capability of generating the public key from the node identity directly, compared with traditional cryptography. In particular, identity-based combined encryption and signature cryptography (IBCES) could encrypt and sign the messages using the same identity. As such, to secure the confidentiality, integrity, and authentication of topology information, we put forward a secure topology control mechanism based on IBCES. First, we use an identity-based encryption authenticated key agreement scheme to implement the authentication of neighbor nodes and hop-to-hop verification via secure neighbor discovery and topology discovery processes. Then through the node admission and key establishment process, the end-to-end secure channels are established between the nodes, sinks, and Controller. Finally, secure topology collection and management processes supporting flat and hierarchical network structures are designed to guarantee the security of topology information. Theoretical analysis shows that our methods could satisfy the security needs of SDWSN topology control and resist several security attacks. The experimental results indicate that our mechanisms are suitable for SDWSNs.
    Type of Medium: Online Resource
    ISSN: 1687-7268 , 1687-725X
    URL: Article
    DOI: 10.1155/2023/6187353
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2397931-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Rh-CXCL-12 Attenuates Neuronal Pyroptosis after Subarachnoid Hemorrhage in Rats via Regulating the CXCR4/NLRP1 Pathway
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-11-9), p. 1-14
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-11-9), p. 1-14
    Abstract: Subarachnoid hemorrhage (SAH) is a cerebrovascular disease associated with high morbidity and mortality. CXCR4 provides neuroprotective effects, which can alleviate brain injury and inflammation induced by stroke. Previous studies have suggested that CXCR4 reduces the pyroptosis of LPS-stimulated BV2 cells. The purpose of this study was to evaluate the antipyroptosis effects and mechanisms of CXCR4 after SAH. SAH animal model was induced via endovascular perforation. A total of 136 male Sprague-Dawley rats were used. Recombinant human cysteine-X-cysteine chemokine ligand 12 (rh-CXCL-12) was administered intranasally at 1 h after SAH induction. To investigate the underlying mechanism, the inhibitor of CXCR4, AMD3100, was administered intraperitoneally at 1 h before SAH. The neurobehavior tests were assessed, followed by performing Western blot and immunofluorescence staining. The Western blot results suggested that the expressions of endogenous CXCL-12, CXCR4, and NLRP1 were increased and peaked at 24 h following SAH. Immunofluorescence staining showed that CXCR4 was expressed on neurons, microglia, and astrocytes. Rh-CXCL-12 treatment improved the neurological deficits and reduced the number of FJC-positive cells, IL-18-positive neurons, and cleaved caspase-1(CC-1)-positive neurons after SAH. Meanwhile, rh-CXCL-12 treatment increased the levels of CXCL-12 and CXCR4, and reduced the levels of NLRP1, IL-18, IL-1β, and CC-1. Moreover, the administration of AMD3100 abolished antipyroptosis effects of CXCL-12 and its regulation of CXCR4 post-SAH. The CXCR4/NLRP1 signaling pathway may be involved in CXCL-12-mediated neuronal pyroptosis after SAH. Early administration of CXCL-12 may be a preventive and therapeutic strategy against brain injury after SAH.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/6966394
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Activation of Endocannabinoid Receptor 2 as a Mechanism of Propofol Pretreatment-Induced Cardioprotection against Ischemia-Reperfusion Injury in Rats
    Hindawi Limited ; 2017
    In:  Oxidative Medicine and Cellular Longevity Vol. 2017 ( 2017), p. 1-18
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2017 ( 2017), p. 1-18
    Abstract: Propofol pretreatment before reperfusion, or propofol conditioning, has been shown to be cardioprotective, while its mechanism is unclear. The current study investigated the roles of endocannabinoid signaling in propofol cardioprotection in an in vivo model of myocardial ischemia/reperfusion (I/R) injury and in in vitro primary cardiomyocyte hypoxia/reoxygenation (H/R) injury. The results showed that propofol conditioning increased both serum and cell culture media concentrations of endocannabinoids including anandamide (AEA) and 2-arachidonoylglycerol (2-AG) detected by LC-MS/MS. The reductions of myocardial infarct size in vivo and cardiomyocyte apoptosis and death in vitro were accompanied with attenuations of oxidative injuries manifested as decreased reactive oxygen species (ROS), malonaldehyde (MDA), and MPO (myeloperoxidase) and increased superoxide dismutase (SOD) production. These effects were mimicked by either URB597, a selective endocannabinoids degradation inhibitor, or VDM11, a selective endocannabinoids reuptake inhibitor. In vivo study further validated that the cardioprotective and antioxidative effects of propofol were reversed by selective CB2 receptor antagonist AM630 but not CB1 receptor antagonist AM251. We concluded that enhancing endogenous endocannabinoid release and subsequent activation of CB2 receptor signaling represent a major mechanism whereby propofol conditioning confers antioxidative and cardioprotective effects against myocardial I/R injury.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2017/2186383
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2455981-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Simulation of the Residual Stress of the Y2O3/Al2O3 Composite Deuterium Permeation Barrier under Thermal Shock
    Hindawi Limited ; 2021
    In:  International Journal of Photoenergy Vol. 2021 ( 2021-2-22), p. 1-12
    Details
    In: International Journal of Photoenergy, Hindawi Limited, Vol. 2021 ( 2021-2-22), p. 1-12
    Abstract: A deuterium permeation barrier is an essential part in the core component of nuclear reactors. It can protect the structure made of steel from being penetrated by deuterium in a fusion reactor. However, residual stress induced in the operation would dramatically influence the mechanical endurance of the coating, threatening the safety of the facilities. In this paper, finite element analysis was conducted to investigate the residual stress in nanoscale Al2O3 and Y2O3 coatings and their composites under thermal shock, from 700°C to 25°C. The max principal stress is assumed as the cause of crack initiation in the coating, because ceramics are brittle and fragile under tensile stress. Max shear stress and max Mises stress in the systems are also analyzed, and the effect of thickness in the range 100 nm to 1000 nm was investigated. The max principal stress in Al2O3 coating reaches its maximum value, 1.33 GPa, when the thickness of coating reaches 450 nm. And the max principal stress decreases at a very low rate as the thickness increases exceeding 450 nm. The max principal stress in Y2O3 coating increases rapidly as the thickness increases when the thickness of the coating is below 250 nm, and the max principal stress is at about 0.9 GPa when the thickness exceeds 500 nm. The max principal stress in the Y2O3/Al2O3 (150 nm) composite coating occurs in the Al2O3 layer and shows no difference from the single layer of 150 nm thick Al2O3 coating. The max principal stress site of all three kinds of coating is located at the edge of the coating 25 nm away from the interface. The result shows that residual thermal stress in the coating increases as the thickness increases when the thickness of the coating is below 200 nm due to the stress singularity of the interface. And as the thickness exceeds 500 nm, the increase in thickness has little impact on the residual thermal stress in the coating. Coating an Y2O3 top layer will not introduce any more residual thermal stress under the thermal shock condition. The Y2O3 coating causes much less residual stress under thermal shock compared with Al2O3 owing to its much lower Young’s modulus. The max principal stress in the 300 nm thick Y2O3 coating is 0.85 GPa while that of the Al2O3 coating is 1.16 GPa. The max residual stress of the composite Y2O3/Al2O3 (150 nm) coating is determined by the Al2O3 layer.
    Type of Medium: Online Resource
    ISSN: 1687-529X , 1110-662X
    URL: Article
    DOI: 10.1155/2021/6684802
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2028941-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...