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  • Hindawi Limited  (27)
  • Xu, Hao  (27)
  • 2020-2024  (27)
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  • Hindawi Limited  (27)
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Language
Years
  • 2020-2024  (27)
Year
  • 1
    Online Resource
    Online Resource
    Identification of a Novel Metastasis-Related miRNAs-Based Signature for Predicting the Prognosis of Hepatocellular Carcinoma
    Hindawi Limited ; 2021
    In:  Journal of Oncology Vol. 2021 ( 2021-1-31), p. 1-14
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2021 ( 2021-1-31), p. 1-14
    Abstract: Hepatocellular carcinoma (HCC) is one of the most common internal malignancies worldwide and is associated with a poor prognosis. Abnormal expression of miRNAs is believed to play a role in the recurrent metastasis of HCC. However, limited studies on the role of miRNAs in HCC metastasis have been carried out. Therefore, this study is aimed at exploring the potential value of metastasis-related miRNAs (MRMs) in HCC. We retrieved MRMs were from the Human Cancer Metastasis Database. Differential miRNAs were identified for tumor samples of HCC patients and normal samples based on the TCGA database. Further, univariate and multivariate Cox regression analyses were used to screen MRMs known to be independent prognostic factors in HCC. These MRMs were then used to build a prognostic signature. All patients were classified into high-risk and low-risk groups based on the median of the signature scores. Moreover, GO and KEGG pathway enrichment analyses were performed to predict the function of these MRMs. Finally, a nomogram was constructed to predict the OS of patients at 1, 2, and 3 years. In our study, a total of seven prognostic MRMs (miR-140-3p, miR-9-5p, miR-942-5p, miR-324-3p, miR-29c-5p, miR-551a, and miR-149-5p) were identified and used for constructing the prognostic signature based on the training cohort. Patients in the low-risk HCC group showed better overall survival (OS) than those in the high-risk group. The results were validated using the validation cohort. In summary, the findings of this study provide evidence that MRMs-based prognostic signature is an independent biomarker in the prognosis of HCC patients.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2021/6629633
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2461349-6
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  • 2
    Online Resource
    Online Resource
    Removal of Matrix Interferences by Nano-MgO and Co-Adsorbents for Accurate Multi-Pesticide Residue Analysis in the Chinese Medicinal Herb, Paeoniae Radix Alba
    Hindawi Limited ; 2021
    In:  Journal of Analytical Methods in Chemistry Vol. 2021 ( 2021-2-4), p. 1-10
    Details
    In: Journal of Analytical Methods in Chemistry, Hindawi Limited, Vol. 2021 ( 2021-2-4), p. 1-10
    Abstract: A simple, accurate, and high-throughput analytical method was developed to detect 123 pesticide residues in Chinese medicinal herb Paeoniae Radix Alba (PRA) by introducing nano-MgO as a highly efficient purification material based on quick, easy, cheap, effective, rugged, and safe (QuEChERS) design concept. Various PRA samples were extracted using 8 mL 0.5% acetic acid-acetonitrile solution and purified by a dispersive solid-phase extraction method with 30 mg nano-MgO, 40 mg primary secondary amine (PSA), and 40 mg octadecylsilane (C18) as the cleanup adsorbents, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). 70.7% of pesticides showed a weak matrix effect after the purification process, indicating that this method can give the precise quantitative analysis of trace pesticides residue. The method was systematically validated under optimal conditions in five different kinds of PRA samples; good linearity was observed in the concentration range of 0.5–250 μg/L or 1–250 μg/L. Pesticide recovery in each sample spiked at concentrations of 20, 50, and 200 μg/kg ranged from 98.0% to 111% and the mean relative standard deviation ranged from 2.72% to 5.70%. Furthermore, the method comparison with the traditional QuEChERS method suggested the feasibility, advantages, and potential application prospect of the present method for the multi-pesticide residue analysis in various PRA samples.
    Type of Medium: Online Resource
    ISSN: 2090-8873 , 2090-8865
    URL: Article
    DOI: 10.1155/2021/6626257
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2654178-6
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  • 3
    Online Resource
    Online Resource
    On-Chip Embedded Debugging System Based on Leach Algorithm Parameter on Detection of Wireless Sensor Networks
    Hindawi Limited ; 2020
    In:  Mathematical Problems in Engineering Vol. 2020 ( 2020-09-07), p. 1-7
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2020 ( 2020-09-07), p. 1-7
    Abstract: Leach (low energy adaptive clustering hierarchy) algorithm is a self-clustering topology algorithm. Its execution process is cyclical. Each cycle is divided into two phases: cluster building phase and stable data communication phase. In the stage of cluster building, the adjacent nodes cluster dynamically and randomly generate cluster heads. In the data communication phase, the nodes in the cluster send the data to the cluster head, and the cluster head performs data fusion and sends the results to the aggregation node. Because the cluster head needs to complete data fusion, communication with the convergence node and other works, the energy consumption is large. Leach algorithm can ensure that each node acts as cluster head with equal probability, so that the nodes in the network consume energy relatively evenly. The basic idea of Leach algorithm is to randomly select cluster head nodes in a circular way. It evenly distributes the energy load of the whole network to each sensor node in the network. It can reduce network energy consumption and improve network life cycle. Leach repeatedly performs cluster refactoring during its operation. This paper studies the parameter detection of wireless sensor network based on Leach algorithm on the on-chip embedded debugging system. Because the classical low-power adaptive clustering layered protocol (Leach) has the problem of energy imbalance and short node life cycle, this paper uses embedded debugging technology based on Leach algorithm and the residual energy and position of nodes in wireless sensor networks were tested for research. This Leach algorithm uses the concept of wheel. Each round consists of two phases: initialization and stabilization. In the initialization stage, each node generates a random number between 0 and 1. If the random number generated by a node is less than the set threshold T (n), the node publishes a message that it is a cluster head. Through the research on the parameter detection, the simulation results show that the research in this paper has good feasibility and rationality.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2020/7249674
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 4
    Online Resource
    Online Resource
    Identification of snoRNA SNORA71A as a Novel Biomarker in Prognosis of Hepatocellular Carcinoma
    Hindawi Limited ; 2020
    In:  Disease Markers Vol. 2020 ( 2020-09-27), p. 1-7
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2020 ( 2020-09-27), p. 1-7
    Abstract: Background . Small nucleolar RNAs (snoRNAs) have been proved to play important roles in various cellular physiological process. Recently, dysregulation of snoRNA SNORA71A has been found involved in tumorigenesis of various malignant cancers. However, the emerging effects of SNORA71A in hepatocellular carcinoma (HCC) remain largely unclear. In this study, we aimed to explore the SNORA71A expression and its underlying significance in HCC. Methods . Expression of SNORA71A in cell lines and clinical specimens was measured by quantitative real-time PCR. Then, all enrolled HCC patients were divided into low and high SNORA71A expression subgroups and then they were compared in the aspects of clinical features as well as survival outcome by respective statistical analysis methods. Results . SNORA71A was significantly downexpressed in SK-HEP-1 ( P = 0.001 ), Huh-7 ( P 〈 0.001 ), Hep3B ( P 〈 0.001 ), and clinical HCC specimens ( P = 0.006 ). Comparing the clinical features between SNORA71A expression subgroups, it showed that low SNORA71A expression was significantly associated with large tumor diameter, multiple lesions, capsular invasion, bad tumor differentiation, and TNM stage ( P 〈 0.05 ). Furthermore, it was found that HCC patients with lower SNORA71A expression had higher risk in postoperative tumor relapse (median time: 9.5 vs. 35.2 months; low vs. high; P 〈 0.001 ) and poor overall survival (median time: 36.8 vs. 52.9 months; low vs. high; P 〈 0.001 ). Besides, SNORA71A expression served as independent risk factors for tumor-free ( HR = 0.450 ; 95% CI [0.263-0.770]; P = 0.004 ) and long-term survival ( HR = 0.289 ; 95% CI [0.127-0.657]; P = 0.003 ). Conclusions . Our study for the first time demonstrated that downregulation of SNORA71A could serve as a novel biomarker for clinical assessment and prognostic prediction of HCC patients.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2020/8879944
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2033253-1
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  • 5
    Online Resource
    Online Resource
    Downregulation of snoRNA SNORA52 and Its Clinical Significance in Hepatocellular Carcinoma
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-6-3), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-6-3), p. 1-7
    Abstract: Hepatocellular carcinoma (HCC) is one of the most common and aggressive tumors in the world while the accuracy of the present tests for detecting HCC is poor. A novel diagnostic and prognostic biomarker for HCC is urgently needed. Overwhelming evidence has demonstrated the regulatory roles of small nucleolar RNA (snoRNA) in carcinogenesis. This study is aimed at analyzing the expression of a snoRNA, SNORA52, in HCC and exploring the correlation between its expression and various clinical characteristics of HCC patients. By using quantitative real-time PCR, we found that SNORA52 was downregulated in HCC cell lines ( P 〈 0.05 ) and HCC tissues ( P 〈 0.001 ). Correlation analysis showed that the expression of SNORA52 was obviously associated with tumor size ( P = 0.011 ), lesion number ( P = 0.007 ), capsular invasion ( P = 0.011 ), tumor differentiation degree ( P = 0.046 ), and TNM stage ( P = 0.004 ). The disease-free survival (DFS) and overall survival (OS) analysis showed that patients with lower SNORA52 expression had a worse prognosis ( P 〈 0.001 ). Univariate and multivariate Cox regression analysis showed that SNORA52 expression was a completely independent prognostic factor to predict DFS ( P = 0.009 ) and OS ( P = 0.012 ) of HCC patients. Overall, our findings showed SNORA52 expression levels were downregulated in HCC tissues and correlated with multiple clinical variables, and SNORA52 was an independent prognostic factor for HCC patients, which suggested that SNORA52 could function as a potential diagnostic and prognostic biomarker for HCC patients.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/7020637
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
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  • 6
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    Online Resource
    Plasma Spectroscopy on Hydrogen-Carbon-Oxygen Foam Targets Driven by Laser-Generated Hohlraum Radiation
    Hindawi Limited ; 2022
    In:  Laser and Particle Beams Vol. 2022 ( 2022-6-17), p. 1-9
    Details
    In: Laser and Particle Beams, Hindawi Limited, Vol. 2022 ( 2022-6-17), p. 1-9
    Abstract: The laboratory generation and diagnosis of uniform near-critical-density (NCD) plasmas play critical roles in various studies and applications, such as fusion science, high energy density physics, astrophysics as well as relativistic electron beam generation. Here we successfully generated the quasistatic NCD plasma sample by heating a low-density tri-cellulose acetate (TCA) foam with the high-power-laser-driven hohlraum radiation. The temperature of the hohlraum is determined to be 20 eV by analyzing the spectra obtained with the transmission grating spectrometer. The single-order diffraction grating was employed to eliminate the high-order disturbance. The temperature of the heated foam is determined to be T = 16.8 ± 1.1 eV by analyzing the high-resolution spectra obtained with a flat-field grating spectrometer. The electron density of the heated foam is about N e = 4.0 ± 0.3 × 10 20 cm − 3 under the reasonable assumption of constant mass density.
    Type of Medium: Online Resource
    ISSN: 1469-803X , 0263-0346
    URL: Article
    DOI: 10.1155/2022/3049749
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2021816-3
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  • 7
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    Online Resource
    An isolated hypogonadotropic hypogonadism male with a novel de novo FGFR1 mutation fathered a normal son evidenced by prenatal genetic diagnosis
    Hindawi Limited ; 2020
    In:  Andrologia Vol. 52, No. 11 ( 2020-12)
    Details
    In: Andrologia, Hindawi Limited, Vol. 52, No. 11 ( 2020-12)
    Type of Medium: Online Resource
    ISSN: 0303-4569 , 1439-0272
    URL: Issue
    URL: Article
    DOI: 10.1111/and.v52.11
    DOI: 10.1111/and.13821
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2009045-6
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  • 8
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    Online Resource
    Cloning of rpl10 in spotted knifejaw ( Oplegnathus punctatus ) and expression pattern analysis after iridovirus infection
    Hindawi Limited ; 2020
    In:  Aquaculture Research Vol. 51, No. 3 ( 2020-03), p. 1256-1263
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 51, No. 3 ( 2020-03), p. 1256-1263
    Type of Medium: Online Resource
    ISSN: 1355-557X , 1365-2109
    URL: Issue
    URL: Article
    DOI: 10.1111/are.v51.3
    DOI: 10.1111/are.14476
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 9
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    Online Resource
    Fang-Ji-Huang-Qi-Tang Attenuates Degeneration of Early-Stage KOA Mice Related to Promoting Joint Lymphatic Drainage Function
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-03-20), p. 1-10
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-03-20), p. 1-10
    Abstract: Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the breakdown of articular cartilage, subchondral bone remodeling, and inflammation of the synovium. In this study, we investigated whether Fang-Ji-Huang-Qi-Tang (FJHQT) decoction improved the joint structure of OA or delayed the process of knee joint degeneration in OA mice by promoting lymphatic drain function. The mice were randomly divided into four groups, the sham group, the PBS group, the FJHQT-treated group, and the Mobic-treated group. The mice in each group were tested for lymphatic draining function at 4, 6, 8, and 10 weeks postsurgery (WPS), then sacrificed ( N  = 10/group). Using a near-infrared indocyanine green (NIR-ICG) lymphatic imaging system, we found that the lymphatic drain function was significantly reduced in the PBS group compared with the sham group. After treatment with the FJHQT decoction, the lymphatic draining function improved at 4 wps and 6 wps. The results of the analysis indicated a strong correlation between lymphatic draining function (ICG clearance) and the degree of joint structural damage (OARSI score). By Alcian blue/orange G (ABOG) staining of the paraffin sections, the FJHQT-treated group exhibited less cartilage destruction and lower OARSI scores. Moreover, the result of immunohistochemical staining (IHC) shows that FJHQT decoction increased the content of type II collagen in knee joints of OA mice at 4 wps and 6 wps. By the double immunofluorescence staining of podoplanin and smooth muscle actin in the paraffin sections, the capillaries and mature lymphatics in the FJHQT group increased at 4 wps. In conclusion, the FJHQT decoction can increase lymphatic vessel number, promote joint lymphatic draining function, and postpone knee osteoarthritis pathologic progression in the early stage of a collagen-induced mouse model. Therefore, the application of sufficient lymphatic drainage in the knee joint may be a new treatment method for knee joint osteoarthritis (KOA).
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2020/3471681
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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  • 10
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    Reversal of idiopathic hypogonadotropic hypogonadism in a Chinese male cohort
    Hindawi Limited ; 2022
    In:  Andrologia Vol. 54, No. 11 ( 2022-12)
    Details
    In: Andrologia, Hindawi Limited, Vol. 54, No. 11 ( 2022-12)
    Type of Medium: Online Resource
    ISSN: 0303-4569 , 1439-0272
    URL: Issue
    URL: Article
    DOI: 10.1111/and.v54.11
    DOI: 10.1111/and.14583
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2009045-6
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