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  • 1
    Online Resource
    Online Resource
    Association of plasma neutrophil gelatinase-associated lipocalin and thoracic aorta calcification in maintenance hemodialysis patients with and without diabetes
    Springer Science and Business Media LLC ; 2022
    In:  BMC Nephrology Vol. 23, No. 1 ( 2022-12)
    Details
    In: BMC Nephrology, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2022-12)
    Abstract: Neutrophil gelatinase-associated lipocalin (NGAL) is not only a bone-derived factor involved in metabolism, but also a biomarker of kidney disease and cardiovascular pathophysiology. We conducted this cross-sectional observational study to explore relationships between plasma NGAL and thoracic aorta calcification (TAC) in maintenance hemodialysis (MHD) patients with and without diabetes. Methods Plasma NGAL was measured by ELISA, TAC was evaluated via computed tomography scan using a 3D quantification method or chest radiography aortic arch calcification score. Spearman correlation, Logistic regression and Partial correlation analysis were used to describe the correlations between NGAL and TAC. Results Plasma NGAL levels were lower in MHD patients with diabetes compared to those without diabetes (49.33(42.37, 55.48) vs 56.78(44.37, 674.13) ng/mL, P  = 0.026). In MHD patients without diabetes, lg (NGAL) was positively correlated with ARC value( R  = 0.612, P  = 0.003) analyzed by Spearman correlation; for partial correlation analysis, lg (NGAL) was positively correlated with ARC value, after adjusting for age and sex ( R  = 0.550, P  = 0.015), adjusting for age, sex and CHD ( R  = 0.565, P  = 0.015), adjusting for age, sex, CHD and Alb ( R  = 0.536, P  = 0.027), or adjusting for age, sex, CHD, Alb, and dialyzer membrane (polysulfone) ( R  = 0.590, P  = 0.016); however, when adjusting for age, sex, CHD, Alb and Ca, the correlation between lg (NGAL) and ARC value disappeared. Positive correlation were found between NGAL and Ca ( R  = 0.644, P   〈  0.001), Ca and ACR ( R  = 0.534, P  = 0.013) in Spearman coefficient analysis. Conclusion There were positive correlations among plasma NGAL, serum Ca and ARC in MHD patients without diabetes; which suggests that NGAL is possibly a participant in cardiovascular calcification, in non-diabetic MHD.
    Type of Medium: Online Resource
    ISSN: 1471-2369
    URL: Article
    DOI: 10.1186/s12882-022-02773-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041348-8
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  • 2
    Online Resource
    Online Resource
    Association between metabolic syndrome and chronic kidney disease in a Chinese urban population
    Elsevier BV ; 2017
    In:  Clinica Chimica Acta Vol. 470 ( 2017-07), p. 103-108
    Details
    In: Clinica Chimica Acta, Elsevier BV, Vol. 470 ( 2017-07), p. 103-108
    Type of Medium: Online Resource
    ISSN: 0009-8981
    URL: Article
    DOI: 10.1016/j.cca.2017.05.012
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 1499920-1
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  • 3
    Online Resource
    Online Resource
    Elevated c-kit expression in failed autologous arteriovenous fistulas in end-stage renal disease patients
    SAGE Publications ; 2022
    In:  The Journal of Vascular Access
    Details
    In: The Journal of Vascular Access, SAGE Publications
    Abstract: Serum stem cell factor is elevated in end-stage renal disease (ESRD) patients. This study aimed to investigate the expression of the c-kit receptor, which is the specific membrane receptor of stem cell factor, in failed autologous arteriovenous fistulas (AVFs) in end-stage renal disease patients. Methods: A total of 14 ESRD patients with initial AVFs creation and 16 ESRD patients with reconstruction were enrolled in this study. Hematoxylin and eosin (H & E) and elastic Verhoeff-Van Gieson (EVG) staining were used for histomorphometric analyses. Immunohistochemistry was used to examine the expression of c-kit in the intima, and a correlation analysis was performed with the intimal area and the percentage of area stenosis. A double-label immunofluorescence method was used to explore the colocalization of c-kit with α-smooth muscle actin (α-SMA) and CD31. The expression of c-kit and the related PI3K/Akt signaling axis, including PI3K, P-PI3K, Akt, P-Akt473, P-Akt308, and mTOR, was measured by western blotting. Results: Internal elastic lamina (IEL) area, intimal area, percentage of area stenosis, and average optical density (AOD) of c-kit in the intima were significantly higher in the failed group than in the preoperative group ( p ⩽ 0.001). The AOD of c-kit in the intima was positively correlated with the intimal area and the percentage of stenosis (intimal area: R = 0.744, p  〈  0.001; the percentage of stenosis: R = 0.923, p  〈  0.001). C-kit colocalized with α-SMA but not with CD31 in studies of c-kit target cells. Moreover, the levels of c-kit and P-PI3K, P-Akt473 and mTOR in the PI3K/Akt axis were also higher in the failed group than in the initial group ( p  〈  0.05). Conclusions: C-kit and related proteins associated with the PI3K/Akt pathway were elevated in failed AVFs among ESRD patients and that the expression level of c-kit in the intima correlates with the degree of AVF stenosis.
    Type of Medium: Online Resource
    ISSN: 1129-7298 , 1724-6032
    URL: Article
    DOI: 10.1177/11297298221112541
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2079292-X
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  • 4
    Online Resource
    Online Resource
    Mineral and bone disorder in Chinese dialysis patients: a multicenter study
    Springer Science and Business Media LLC ; 2012
    In:  BMC Nephrology Vol. 13, No. 1 ( 2012-12)
    Details
    In: BMC Nephrology, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2012-12)
    Abstract: Mineral and bone disorder (MBD) in patients with chronic kidney disease is associated with increased morbidity and mortality. Studies regarding the status of MBD treatment in developing countries, especially in Chinese dialysis patients are extremely limited. Methods A cross-sectional study of 1711 haemodialysis (HD) patients and 363 peritoneal dialysis (PD) patients were enrolled. Parameters related to MBD, including serum phosphorus (P), calcium (Ca), intact parathyroid hormone (iPTH) were analyzed. The achievement of MBD targets was compared with the results from the Dialysis Outcomes and Practice Study (DOPPS) 3 and DOPPS 4. Factors associated with hyperphosphatemia were examined. Results Total 2074 dialysis patients from 28 hospitals were involved in this study. Only 38.5%, 39.6% and 26.6% of them met the Kidney Disease Outcomes Quality Initiative (K/DOQI) defined targets for serum P, Ca and iPTH levels. Serum P and Ca levels were statistically higher (P  〈  0.05) in the HD patients compared with those of PD patients, which was (6.3 ± 2.1) mg/dL vs (5.7 ± 2.0) mg/dL and (9.3 ± 1.1) mg/dL vs (9.2 ± 1.1) mg/dL, respectively. Serum iPTH level were statistically higher in the PD patients compared with those of HD patients (P = 0.03). The percentage of patients reached the K/DOQI targets for P (37.6% vs 49.8% vs 54.5%, P  〈  0.01), Ca (38.6% vs 50.4% vs 56.0%, P  〈  0.01) and iPTH (26.5% vs 31.4% vs 32.1%, P  〈  0.01) were lower among HD patients, compared with the data from DOPPS 3 and DOPPS 4. The percentage of patients with serum phosphorus level above 5.5 mg/dL was 57.4% in HD patients and 47.4% in PD patients. Age, dialysis patterns and region of residency were independently associated with hyperphosphatemia. Conclusions Status of MBD is sub-optimal among Chinese patients receiving dialysis. The issue of hyperphosphatemia is prominent and needs further attention.
    Type of Medium: Online Resource
    ISSN: 1471-2369
    URL: Article
    DOI: 10.1186/1471-2369-13-116
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2012
    detail.hit.zdb_id: 2041348-8
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  • 5
    Online Resource
    Online Resource
    Association Between Body Composition and Glomerular Hyperfiltration Among Chinese Adults
    Wiley ; 2020
    In:  Therapeutic Apheresis and Dialysis Vol. 24, No. 4 ( 2020-08), p. 439-444
    Details
    In: Therapeutic Apheresis and Dialysis, Wiley, Vol. 24, No. 4 ( 2020-08), p. 439-444
    Abstract: High body mass index (BMI) is the most common parameter to assess excess adiposity, and has been linked to glomerular hyperfiltration (GH). However, BMI may be misleading in the estimation of body fat content due to its inability to discriminate between body fat and lean mass. In recent years, the convenient biological impedance analysis has made prediction of certain diseases somewhat feasible and accessible using body composition (BC). Accordingly, we conducted a cross‐sectional study to explore the association between BC and GH among Chinese adult population. A total of 6902 adults (aged 38.6 ± 8.3 years, 70.1% males) who consecutively visited the Health Checkup Clinic were enrolled. BC including fat mass and lean body mass (LBM) was evaluated by biological impedance analysis. The upper quartile of eGFR which exceeded 117.3 mL/min/1.73 m 2 was defined as GH, in comparison with the lower three quartiles (control group). As a categorical outcome, GH subjects had higher fat/LBM than the control group, which was 34.7 ± 10.9 (%) vs. 34.0 ± 10.5 (%), P = 0.01; however, the BMI in GH group was lower than in the control group, which was 24.5 ± 3.7 (%) vs. 24.9 ± 3.6 (%), P 〈  0.001. Fat/height and Fat/BSA were not significantly different between the two groups. Moreover, after adjusting for potential confounders, fat/LBM significantly correlated with GH (OR = 2.09, 95% CI, 1.11 to 3.93). The study revealed that fat/LBM significantly correlated with GH among Chinese adult population, which highlights that adiposity might be an important and potentially modifiable determinant of GH.
    Type of Medium: Online Resource
    ISSN: 1744-9979 , 1744-9987
    URL: Issue
    URL: Article
    DOI: 10.1111/tap.v24.4
    DOI: 10.1111/1744-9987.13436
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2010864-3
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  • 6
    Online Resource
    Online Resource
    Total parathyroidectomy with autotransplantation versus subtotal parathyroidectomy for renal hyperparathyroidism: A systematic review and meta‐analysis
    Wiley ; 2017
    In:  Nephrology Vol. 22, No. 5 ( 2017-05), p. 388-396
    Details
    In: Nephrology, Wiley, Vol. 22, No. 5 ( 2017-05), p. 388-396
    Abstract: There are few analyses assessing parathyroidectomy versus medical therapy or of total parathyroidectomy with autotransplantation versus subtotal parathyroidectomy. In this paper, which includes meta analysis of 13 retrospective and prospective studies (1589 patients), these surgical procedures are compared. It will be a surprise to some that there were no statistically significant differences in surgical complications, recurrence or longer term outcomes between these surgical techniques.
    Type of Medium: Online Resource
    ISSN: 1320-5358 , 1440-1797
    URL: Issue
    URL: Article
    DOI: 10.1111/nep.2017.22.issue-5
    DOI: 10.1111/nep.12801
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2008235-6
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