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  • Hindawi Limited  (22)
  • Xu, Chao  (22)
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  • Hindawi Limited  (22)
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  • 1
    Online Resource
    Online Resource
    Association between Normal Thyroid Hormones and Diabetic Retinopathy in Patients with Type 2 Diabetes
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-02-13), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-02-13), p. 1-7
    Abstract: The relationship between normal thyroid function and type 2 diabetes mellitus (T2DM) has been a particular focus for concern. The present study determined the relationship between thyroid hormone levels and the prevalence of diabetic retinopathy (DR) in T2DM patients. A cross-sectional study ( n  = 633) was performed in Xi’an, Shaanxi Province, China. Subjects were evaluated for anthropometric measurements, thyroid function, and diabetic retinopathy. Logistic regression models were used to assess the relationships between thyroid hormones and DR. Of 633 patients, 243 (38.4%) patients suffered from DR. The prevalence of DR showed a significantly decreasing trend across the quartiles based on free triiodothyronine (FT3) (FT3 quartile 1 group [FT3-Q1] 〈 4.35 pmol/L, FT3 quartile 2 group [FT3-Q2] 4.35–4.70 pmol/L, FT3 quartile 3 group [FT3-Q3] 4.70–5.08 pmol/L, and FT3 quartile 4 group [FT3-Q4] ≥5.08 pmol/L) (56.7%, 42.5%, 33.1%, 23.8%, P 〈 0.001 ). In comparison with all participants categorized in FT3-Q1, the multivariable adjusted odds ratios (95% confidence interval) of DR in FT3-Q2, FT3-Q3, and FT3-Q4 were 0.587 (0.340–1.012), 0.458 (0.258–0.813), and 0.368 (0.201–0.673), ( P = 0.055 , P = 0.008 , P = 0.001 ), respectively. FT3 levels within the normal range are negatively associated with DR in euthyroid patients with type 2 diabetes. Further studies should be aimed at clarifying the relationship between thyroid hormones and T2DM.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2020/8161797
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2698540-8
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  • 2
    Online Resource
    Online Resource
    Acoustic Emission and Fractal Precursory Characteristics of Coals with Different Bursting Liabilities in Loading Failure Process
    Hindawi Limited ; 2021
    In:  Shock and Vibration Vol. 2021 ( 2021-7-12), p. 1-11
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2021 ( 2021-7-12), p. 1-11
    Abstract: Aimed at investigating the differentiation of acoustic emission (AE) signals and fractal precursory characteristics between strong, weak, and no bursting liability coals under uniaxial compression, as well as improving the accuracy of rockburst monitoring and early warning by AE techniques, we experimentally studied the evolution law and differences of AE ring count rate, energy rate, and correlation dimension between different loaded bursting liability coals by the YAW4306 electric mechanical test system and CTA-1 AE monitor. Our experimental results indicated that the AE count and energy of coal samples with different bursting liabilities showed a similar evolution law of “sharp increase-calm-sharp increase” before their main rupture. The active points of AE signals emitted from coal with strong, weak, and no bursting liability appeared at about 85∼90%, 75∼78%, and 51∼55% of the peak stress, respectively. The stronger the bursting liability of coal, the shorter the duration of main rupture and postpeak failure stage, and the greater the AE energy rate in the main rupture. The AE counts of different coals had obvious fractal characteristics, and the AE correlation dimension values of strong and weak bursting liability coal samples presented the phenomenon of “fluctuating rise to a peak value-sharp drop-continuous decrease,” which can be used as a precursory information of coal failure.
    Type of Medium: Online Resource
    ISSN: 1875-9203 , 1070-9622
    URL: Article
    DOI: 10.1155/2021/9930407
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2070162-7
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  • 3
    Online Resource
    Online Resource
    Adsorption Characteristics of Fumaric Acid onto Weakly Basic Hypercrosslinked Polystyrene Ion-Exchangers
    Hindawi Limited ; 2006
    In:  Adsorption Science & Technology Vol. 24, No. 1 ( 2006-02), p. 65-77
    Details
    In: Adsorption Science & Technology, Hindawi Limited, Vol. 24, No. 1 ( 2006-02), p. 65-77
    Type of Medium: Online Resource
    ISSN: 0263-6174 , 2048-4038
    URL: Article
    DOI: 10.1260/026361706778062559
    RVK:
    VA 1500
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2006
    detail.hit.zdb_id: 2017917-0
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  • 4
    Online Resource
    Online Resource
    The Importance of Fatty Acid Precision Nutrition: Effects of Dietary Fatty Acid Composition on Growth, Hepatic Metabolite, and Intestinal Microbiota in Marine Teleost Trachinotus ovatus
    Hindawi Limited ; 2023
    In:  Aquaculture Nutrition Vol. 2023 ( 2023-1-11), p. 1-19
    Details
    In: Aquaculture Nutrition, Hindawi Limited, Vol. 2023 ( 2023-1-11), p. 1-19
    Abstract: Our recent study demonstrated that diet with blend oil (named BO1) as lipid, which is designed on the base of essential fatty acid requirement of Trachinotus ovatus, achieved good performance. Here, to confirm its effect and investigate the mechanism, three isonitrogenous (45%) and isolipidic (13%) diets (D1-D3) only differing in dietary lipids, which were, respectively, fish oil (FO), BO1, and blend oil 2 (BO2) consisting of FO and soybean oil at 2 : 3, were formulated and used to feed the T. ovatus juveniles (average initial weight: 7.65 g) for 9 weeks. The results showed that the weight gain rate of fish fed D2 was higher than that of fish fed D3 ( P 〈 0.05 ) and had no significant difference from that of fish fed D1 ( P 〉 0.05 ). Correspondingly, compared with the D3 group, fish of the D2 group exhibited better oxidative stress parameters such as lower serum malondialdehyde content and inflammatory indexes in the liver such as the lower expression level of genes encoding four interleukin proteins and tumor necrosis factor α, as well as higher hepatic immune-related metabolites such as valine, gamma-aminobutyric acid, pyrrole-2-carboxylic acid, tyramine, l-targinine, p-synephrine, and butyric acid ( P 〈 0.05 ). Furthermore, the intestinal probiotic (Bacillus) proportion was significantly higher, while the pathogenic bacteria (Mycoplasma) proportion was significantly lower in the D2 group than that in the D3 group ( P 〈 0.05 ). The main differential fatty acids of diet D2 were close to those of D1, while the levels of linoleic acid and n-6 PUFA, as well as the ratio of DHA/EPA of D3, were higher than those of D1 and D2. These results indicated that the better performance of D2 such as enhancing growth, reducing oxidative stress, and improving immune responses and intestinal microbial communities in T. ovatus may be mainly due to the good fatty acid composition of BO1, which indicated the importance of fatty acid precision nutrition.
    Type of Medium: Online Resource
    ISSN: 1365-2095 , 1353-5773
    URL: Article
    DOI: 10.1155/2023/2556799
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2019893-0
    SSG: 21,3
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  • 5
    Online Resource
    Online Resource
    Dietary raw starch to gelatinized starch ratios: Effects on the growth performance, digestive functions, intestinal histology and growth hormone‐insulin‐like growth factor‐I axis of blunt snout bream Megalobrama amblycephala
    Hindawi Limited ; 2020
    In:  Aquaculture Research Vol. 51, No. 2 ( 2020-02), p. 707-718
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 51, No. 2 ( 2020-02), p. 707-718
    Type of Medium: Online Resource
    ISSN: 1355-557X , 1365-2109
    URL: Issue
    URL: Article
    DOI: 10.1111/are.v51.2
    DOI: 10.1111/are.14420
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 6
    Online Resource
    Online Resource
    Fracture Characteristics and Zoning Model of Overburden during Longwall Mining
    Hindawi Limited ; 2021
    In:  Shock and Vibration Vol. 2021 ( 2021-9-1), p. 1-12
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2021 ( 2021-9-1), p. 1-12
    Abstract: The fracture characteristics and zoning model of overburden during longwall mining are the basis of coal mine disaster prevention. However, the existing theoretical model is inconsistent with the field measurement. In order to further research into the strata’s fracture characteristics and optimize the overburden’s zoning model, we used the elasticity and Winkler foundation theory to establish first fracture and periodic fracture mechanics models of clamped boundary supported by an elastic foundation with a key stratum as the research object. We analyzed the stress distribution characteristics and fracture evolution pattern of the mining-induced key stratum. We analyzed the zoning characteristics of mining-induced overburden and established the zoning model according to different fracture mechanisms. The results show that the key stratum formed a double “O-X” shaped interconnected fracture zone after the first fracture. The key stratum formed a double “C-K” shaped interconnected fracture zone after the periodic fracture. We divided the mining-induced overburden into three zones along the horizontal direction: the original rock zone, the inverted triangular compression-shear fracture zone, and the trapezoidal tensile fracture zone. The study revealed the mechanism of inverted step fracture in the separation zone, explained the fracture mechanism of the coal pillar support zone, and has significant theoretical value for the prevention and control of water disasters, gas outbursts, and strata movement.
    Type of Medium: Online Resource
    ISSN: 1875-9203 , 1070-9622
    URL: Article
    DOI: 10.1155/2021/2857750
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2070162-7
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  • 7
    Online Resource
    Online Resource
    Nicotinamide improves the growth performance, intermediary metabolism and glucose homeostasis of blunt snout bream Megalobrama amblycephala fed high‐carbohydrate diets
    Hindawi Limited ; 2020
    In:  Aquaculture Nutrition Vol. 26, No. 4 ( 2020-08), p. 1311-1328
    Details
    In: Aquaculture Nutrition, Hindawi Limited, Vol. 26, No. 4 ( 2020-08), p. 1311-1328
    Type of Medium: Online Resource
    ISSN: 1353-5773 , 1365-2095
    URL: Issue
    URL: Article
    DOI: 10.1111/anu.v26.4
    DOI: 10.1111/anu.13088
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2019893-0
    SSG: 21,3
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  • 8
    Online Resource
    Online Resource
    Identification and Functional Characterization of a Novel Variant in the SEMA3A Gene in a Chinese Family with Kallmann Syndrome
    Hindawi Limited ; 2022
    In:  International Journal of Endocrinology Vol. 2022 ( 2022-10-11), p. 1-10
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2022 ( 2022-10-11), p. 1-10
    Abstract: Background. Kallmann syndrome (KS) is a rare genetic disease characterized by the reproductive system and olfactory dysplasia due to the defective migration of gonadotropin-releasing hormone (GnRH) neurons. However, this disorder is clinically heterogeneous and the genotype-phenotype relationship has not been determined. Objective. The present study aimed to identify the variant causing KS in a Chinese family and evaluate the functional consequences and phenotypes associated with the novel variant. Methods. A Chinese family with KS was screened for pathogenic variants by whole-exome sequencing (WES). Bioinformatic analysis was performed to predict the consequences of the identified variant. The expression of the mutant protein was examined in vitro. Results. A novel heterozygous variant (NM_006080.2 : c.814G  〉  T) in SEMA3A was identified in the patient and his father, which caused the substitution of aspartic acid with tyrosine in codon 272. It was predicted to result in pathogenic significance with a high damaging score and seriously affect protein structure by bioinformatic analysis. In vitro experiments revealed this variant could significantly decrease the expression of SEMA3A. Furthermore, it may cause the disease by failing to induce the phosphorylation of focal adhesion kinase (FAK) in GnRH neurons. Conclusion. Identification and functional characterization of this novel variant in the SEMA3A gene in a Chinese family with Kallmann syndrome extend the genetic variant spectrum of SEMA3A and provide more data about the heterogeneity of KS, which may provide further insights into the diagnosis of KS and help patients get additional data in genetic counseling and timely treatment.
    Type of Medium: Online Resource
    ISSN: 1687-8345 , 1687-8337
    URL: Article
    DOI: 10.1155/2022/2504660
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2502951-4
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  • 9
    Online Resource
    Online Resource
    Time-Domain Structural Damage Identification Using Ensemble Bagged Trees and Evolutionary Optimization Algorithms
    Hindawi Limited ; 2023
    In:  Structural Control and Health Monitoring Vol. 2023 ( 2023-3-15), p. 1-20
    Details
    In: Structural Control and Health Monitoring, Hindawi Limited, Vol. 2023 ( 2023-3-15), p. 1-20
    Abstract: This paper presents a two-step vibration-based strategy for damage identification of framed structures using ensemble bagged trees known as a well-known supervised machine learning (ML) paradigm in conjunction with evolutionary optimization algorithms. The proposed model incorporates the actual response, wavelet coefficients, and wavelet energy to extract damage-sensitive features from the time-domain of the measured and simulated signals. Unlike available studies in this scope, the key objective of this research is to identify damage with a localization precision down to a single structural member, rather than limiting the evaluation to the group of elements. In order to increase the training performance in contributing to extremely large datasets with numerous class labels, the proposed strategy involves the artificial generation of features. Additionally, a modified genetic algorithm is proposed for fast damage localization. It is deduced that the damage locations are confidently detected within a fast computational time. Subsequently, damage identification is followed by the application of evolutionary optimization algorithms. For comparison purpose, the employment of the water cycle optimization algorithm (WCA) is comparatively investigated with the other three state-of-the-art optimizers, i.e., particle swarm optimization (PSO), imperialist competitive algorithm (ICA), and differential evolution algorithm (DE). The numerical and experimental validation studies evidence satisfactorily reliable identification results with no false detection in dealing with multiple damage scenarios in large-scale and real-world applications. It is concluded that developing the most damage-sensitive features and using the proposed data fusion strategy lead to informative features with a reasonably small size and significantly improve the ML performance.
    Type of Medium: Online Resource
    ISSN: 1545-2263 , 1545-2255
    URL: Article
    DOI: 10.1155/2023/6321012
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2146618-X
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  • 10
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    Online Resource
    Epidemiology of Human Respiratory Viruses in Children with Acute Respiratory Tract Infections in Jinan, China
    Hindawi Limited ; 2013
    In:  Clinical and Developmental Immunology Vol. 2013 ( 2013), p. 1-8
    Details
    In: Clinical and Developmental Immunology, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
    Abstract: The viral etiologies of UTRIs and LTRIs in children in Jinan city were investigated between July 2009 and June 2010. Nasal and throat swabs were collected from 397 children with URTIs and bronchoalveolar lavage fluid specimens were collected from 323 children with LRTIs. RT-PCR/PCR was used to examine all samples for IFV, PIV, RSV, RV, hMPV, HBoV, CoV, ADV, RSV, and EV. Viral pathogens were detected in 47.10% of URTI samples and 66.57% samples, and the incidence of viral coinfection was 5.29% and 21.05%, respectively. IFV was the most common virus in URTIs, with a detection rate of 19.40%, followed by PIV (10.83%), RV (10.58%), and EV (6.30%). For LRTIs, PIV and RV were both detected in 27% of samples, followed by RSV (9.91%), HBoV (8.36%), IFV (5.57%), and hMPV (5.57%). RSV and HBoV were more prevalent in the youngest children of no more than six months. Meanwhile, RV, PIV, and RSV were the most frequent viruses combined with bacterial pathogens in LRTIs. In conclusion, the spectrum of respiratory virus infections in URTIs and LRTIs differed in terms of the most common pathogens, seasonal distribution, and coinfection rate.
    Type of Medium: Online Resource
    ISSN: 1740-2522 , 1740-2530
    URL: Article
    DOI: 10.1155/2013/210490
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2817541-4
    detail.hit.zdb_id: 2119272-8
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