In:
Cancer Science, Wiley, Vol. 110, No. 7 ( 2019-07), p. 2180-2188
Abstract:
Novel diagnostic and prognostic biomarkers of cancers are needed to improve precision medicine. Circular RNA s act as important regulators in cancers at the transcriptional and posttranscriptional levels. The circular RNA circ MAN 1A2 is highly expressed in nasopharyngeal carcinoma according to our previous RNA sequencing data; however, the expression and functions of circ MAN 1A2 in cancers are still obscure. Therefore, in this study, we evaluated the expression of circ MAN 1A2 in the sera of patients with nasopharyngeal carcinoma and other malignant tumors and analyzed its correlations with clinical features and diagnostic values. The expression levels of circ MAN 1A2 were detected by quantitative real‐time PCR, and the correlations of clinical features with circ MAN 1A2 expression were analyzed by χ 2 tests. Receiver operating characteristic curves were used to evaluate the clinical applications of circ MAN 1A2 . The results showed that circ MAN 1A2 was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0.911, 0.779, 0.734, 0.694, and 0.645, respectively, indicating the good diagnostic value of circ MAN 1A2 . Overall, our findings suggested that circ MAN 1A2 could be a serum biomarker for malignant tumors, providing important insights into diagnostic approaches for malignant tumors. Further studies are needed to elucidate the mechanisms of circ MAN 1A2 in the pathogenesis of cancer.
Type of Medium:
Online Resource
ISSN:
1347-9032
,
1349-7006
DOI:
10.1111/cas.2019.110.issue-7
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2115647-5
detail.hit.zdb_id:
2111204-6
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