In:
Cardiology, S. Karger AG, Vol. 147, No. 3 ( 2022), p. 290-297
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 The Amplatzer and Watchman left atrial appendage closure (LAAC) devices are the two most frequently used devices for LAAC devices worldwide. This meta-analysis aimed to compare the safety and efficacy of the two devices. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We searched the PubMed, EMBASE, and the Cochrane Library for studies up to February 6, 2022 that compared the safety and efficacy of the Amplatzer and Watchman devices. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Fifteen studies including 2,150 patients in randomized controlled trials and 2,526 patients in observational studies were included in the meta-analysis. Amplatzer device was associated with higher rates of major procedure-related complications (odds ratio [OR]: 1.99, 95% confidence interval [CI] : 1.45–2.74, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001) and device embolization (OR: 1.99, 95% CI: 1.09–3.64, 〈 i 〉 p 〈 /i 〉 = 0.03). However, Amplatzer device had lower rates of total peridevice leak (PDL) (OR: 0.48, 95% CI: 0.27–0.83, 〈 i 〉 p 〈 /i 〉 = 0.009), significant PDL (OR: 0.27, 95% CI: 0.12–0.57, 〈 i 〉 p 〈 /i 〉 = 0.0007) and device-related thrombus (DRT) (OR: 0.67, 95% CI: 0.48–0.95, 〈 i 〉 p 〈 /i 〉 = 0.02). No statistical differences were observed between the two devices in other safety and efficacy endpoints, such as pericardial effusion, cardiac tamponade, air embolism, vascular complications, ischemic stroke/transient ischemic attack (TIA), hemorrhagic stroke, all-cause death, cardiovascular death, and bleeding. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Amplatzer LAAC device was associated with higher rates of major procedure-related complications, especially in device embolization. Watchman LAAC device was associated with higher rates of PDL and DRT. There were no significant differences between two devices in ischemic stroke/TIA, hemorrhagic stroke, all-cause death, cardiovascular death, and bleeding.
Type of Medium:
Online Resource
ISSN:
0008-6312
,
1421-9751
Language:
English
Publisher:
S. Karger AG
Publication Date:
2022
detail.hit.zdb_id:
1482041-9
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