In:
Journal of Clinical Laboratory Analysis, Wiley, Vol. 34, No. 10 ( 2020-10)
Abstract:
Few studies have assessed the sensitization of mycotic allergens and Aspergillus fumigatus molecular allergens. This study aimed to investigate the relationships of A fumigatus components and mycotic allergens in allergic bronchopulmonary aspergillosis (ABPA) patients and A fumigatus (Af)‐sensitized asthma patients. Methods Serum sIgE levels of Penicillium chrysogenum , Cladosporium herbarum , Mucor racemosus , Candida albicans , Alternaria alternata , Helminthosporium halodes, and A fumigatus allergen components (Asp f 1, Asp f 2, Asp f 3, Asp f 4, and Asp f 6) were measured via the ImmunoCAP assay in 18 ABPA and 54 Af‐sensitized asthma patients in Guangzhou city, China. Results 94.44% of ABPA patients and 87.04% of Af‐sensitized asthma patients were co‐sensitized to at least one other fungal allergen. The positive rates of Asp f 1 (88.89% vs 59.26%, P 〈 .05), Asp f 2 (66.67% vs 33.33%, P 〈 .05), Asp f 4 (61.11% vs 33.33%, P 〈 .05), and Asp f 6 (66.67% vs 14.81%, P 〈 .001) in ABPA patients were higher than those in Af‐sensitized asthma patients. IgE levels of Asp f 1 ( P 〈 .05), Asp f 4 ( P 〈 .05), and Asp f 6 ( P 〈 .001) were higher in ABPA patients than in Af‐sensitized asthma patients. Optimal scale analysis showed that ABPA was more relevant to Af components (Cronbach's alpha = 90.7%). Conclusion The A fumigatus components and their relationships with various mycotic allergens were different in ABPA and Af‐sensitized asthma patients. This finding may help local doctors in the diagnosis and immunotherapy of fungal allergies.
Type of Medium:
Online Resource
ISSN:
0887-8013
,
1098-2825
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2001635-9
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