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  • Wu, Yuanyuan  (218)
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  • 1
    Online Resource
    Online Resource
    Mechanical Properties and In Vitro Biocompatibility of Hybrid Polymer-HA/BAG Ceramic Dental Materials
    MDPI AG ; 2022
    In:  Polymers Vol. 14, No. 18 ( 2022-09-09), p. 3774-
    Details
    In: Polymers, MDPI AG, Vol. 14, No. 18 ( 2022-09-09), p. 3774-
    Abstract: The aim of this study is to prepare hybrid polymer–ceramic dental materials for chairside computer-aided design/computer-aided manufacturing (CAD/CAM) applications. The hybrid polymer–ceramic materials were fabricated via infiltrating polymerizable monomer mixtures into sintered hydroxyapatite/bioactive glass (HA/BAG) ceramic blocks and thermo-curing. The microstructure was observed by scanning electron microscopy and an energy-dispersive spectrometer. The phase structure was analyzed by X-ray diffraction. The composition ratio was analyzed by a thermogravimetric analyzer. The hardness was measured by a Vickers hardness tester. The flexural strength, flexural modulus, and compressive strength were measured and calculated by a universal testing machine. The growth of human gingival fibroblasts was evaluated by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) colorimetric assay and immunofluorescence staining. The results showed that the sintering temperature and BAG content affected the mechanical properties of the hybrid polymer–ceramic materials. The X-ray diffraction analysis showed that high-temperature sintering promoted the partial conversion of HA to β-tricalcium phosphate. The values of the hardness, flexural strength, flexural modulus, and compressive strength of all the hybrid polymer–ceramic materials were 0.89–3.51 GPa, 57.61–118.05 MPa, 20.26–39.77 GPa, and 60.36–390.46 MPa, respectively. The mechanical properties of the hybrid polymer–ceramic materials were similar to natural teeth. As a trade-off between flexural strength and hardness, hybrid polymer–ceramic material with 20 wt.% BAG sintered at 1000 °C was the best material. In vitro experiments confirmed the biocompatibility of the hybrid polymer–ceramic material. Therefore, the hybrid polymer–ceramic material is expected to become a new type of dental restoration material.
    Type of Medium: Online Resource
    ISSN: 2073-4360
    URL: Article
    DOI: 10.3390/polym14183774
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2527146-5
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  • 2
    Online Resource
    Online Resource
    A class of metal diboride electrocatalysts synthesized by a molten salt-assisted reaction for the hydrogen evolution reaction
    Royal Society of Chemistry (RSC) ; 2019
    In:  Chemical Communications Vol. 55, No. 59 ( 2019), p. 8627-8630
    Details
    In: Chemical Communications, Royal Society of Chemistry (RSC), Vol. 55, No. 59 ( 2019), p. 8627-8630
    Type of Medium: Online Resource
    ISSN: 1359-7345 , 1364-548X
    URL: Article
    DOI: 10.1039/C9CC03638E
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2019
    detail.hit.zdb_id: 1472881-3
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  • 3
    Online Resource
    Online Resource
    Standardized Saponin Extract from Baiye No.1 Tea (Camellia sinensis) Flowers Induced S Phase Cell Cycle Arrest and Apoptosis via AKT-MDM2-p53 Signaling Pathway in Ovarian Cancer Cells
    MDPI AG ; 2020
    In:  Molecules Vol. 25, No. 15 ( 2020-07-31), p. 3515-
    Details
    In: Molecules, MDPI AG, Vol. 25, No. 15 ( 2020-07-31), p. 3515-
    Abstract: Ovarian cancer is considered to be one of the most serious malignant tumors in women. Natural compounds have been considered as important sources in the search for new anti-cancer agents. Saponins are characteristic components of tea (Camellia sinensis) flower and have various biological activities, including anti-tumor effects. In this study, a high purity standardized saponin extract, namely Baiye No.1 tea flower saponin (BTFS), which contained Floratheasaponin A and Floratheasaponin D, were isolated from tea (Camellia sinensis cv. Baiye 1) flowers by macroporous resin and preparative liquid chromatography. Then, the component and purity were detected by UPLC-Q-TOF/MS/MS. This high purity BTFS inhibited the proliferation of A2780/CP70 cancer cells dose-dependently, which is evidenced by the inhibition of cell viability, reduction of colony formation ability, and suppression of PCNA protein expression. Further research found BTFS induced S phase cell cycle arrest by up-regulating p21 proteins expression and down-regulating Cyclin A2, CDK2, and Cdc25A protein expression. Furthermore, BTFS caused DNA damage and activated the ATM-Chk2 signaling pathway to block cell cycle progression. Moreover, BTFS trigged both extrinsic and intrinsic apoptosis—BTFS up-regulated the expression of death receptor pathway-related proteins DR5, Fas, and FADD and increased the ratio of pro-apoptotic/anti-apoptotic proteins of the Bcl-2 family. BTFS-induced apoptosis seems to be related to the AKT-MDM2-p53 signaling pathway. In summary, our results demonstrate that BTFS has the potential to be used as a nutraceutical for the prevention and treatment of ovarian cancer.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules25153515
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2008644-1
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  • 4
    Online Resource
    Online Resource
    Systematic oxidative stress is not associated with live birth rate in young non-obese patients with polycystic ovarian syndrome undergoing assisted reproduction cycles: A prospective cohort study
    Elsevier BV ; 2020
    In:  European Journal of Obstetrics & Gynecology and Reproductive Biology Vol. 253 ( 2020-10), p. 154-161
    Details
    In: European Journal of Obstetrics & Gynecology and Reproductive Biology, Elsevier BV, Vol. 253 ( 2020-10), p. 154-161
    Type of Medium: Online Resource
    ISSN: 0301-2115
    URL: Article
    DOI: 10.1016/j.ejogrb.2020.07.049
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2005196-7
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  • 5
    Online Resource
    Online Resource
    Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF- κ B Pathway
    Hindawi Limited ; 2020
    In:  Mediators of Inflammation Vol. 2020 ( 2020-05-15), p. 1-21
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2020 ( 2020-05-15), p. 1-21
    Abstract: Relieving Sore Throat Formula (RSTF) is a formula approved by the China Food and Drug Administration and has been used for the treatment of pharyngitis in clinic for many years. However, the potential pharmacological mechanism still remains unknown. We combined multiple methods including bioinformatics data digging, network pharmacology analysis, and pathway analysis to predict the potential target of RSTF. We verified our in silico prediction results with an in vivo/vitro antibacterial effect test, mouse phagocytic index test, proliferation, transformation, and migration of mouse spleen lymphocytes. Alteration of NF- κ B pathway was determined by Western blotting, immunofluorescence, and PCR. The in vivo experiments demonstrated that the RSTF could significantly relieve the symptoms of pharyngitis. A rat saliva secretion test showed that RSTF can effectively relieve the xerostomia symptom. A phenol red excretion test showed that RSTF has an eliminating phlegm effect. A hot plate method and granuloma experiment proved that RSTF also have analgesic and anti-inflammatory effects. In silico prediction demonstrates that 70 active compounds of RSTF were filtered out through ADME screening and 84 putative targets correlated with different diseases. Pathway enrichment analysis showed that the candidate targets were mostly related to the response to bacteria and immunity signalling pathways, which are known contributors to pharyngitis. Experimental results confirmed that RSTF exerted therapeutic effects on pharyngitis mainly by antibacterial effect and downregulation of NF- κ B activities. It is demonstrated both in silico and in vivo/vitro that RSTF exerted therapeutic effects on pharyngitis mainly through an antibiotic effect and downregulation of NF- κ B signalling pathway.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2020/2929163
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2008065-7
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  • 6
    Online Resource
    Online Resource
    Significance of 4D US parameters for the clinical treatment of female patients with stress urinary incontinence
    Frontiers Media SA ; 2023
    In:  Frontiers in Surgery Vol. 10 ( 2023-7-21)
    Details
    In: Frontiers in Surgery, Frontiers Media SA, Vol. 10 ( 2023-7-21)
    Abstract: Stress urinary incontinence (SUI) that has been associated with abnormal pelvic floor muscle function or morphology is a common condition. This research aimed to study the impact of the four-dimensional (4D) pelvic floor ultrasound on the treatment of female patients with clinical diagnosis of SUI and to evaluate its clinical significance on SUI. Methods We enrolled 51 women with SUI. Before transobturator suburethral tape procedures, the patients underwent 4D pelvic floor ultrasonography. The measurements include residual urine volume, bladder detrusor thickness in resting state, the vertical distance from the bladder neck to the posterior inferior edge of pubic symphysis at rest and Valsalva movement, posterior angle of bladder urethra, and urethral rotation angle. The degree of movement of the bladder neck (the difference between the vertical distance from the bladder neck to the posterior inferior edge of the pubic symphysis under the resting state and the maximum Valsalva movement) and the formation of a funnel at the internal orifice of the urethra were calculated. Results The mean bladder detrusor thickness was 2.6 ± 0.9 mm, the vertical distance from the bladder neck to the posterior inferior edge of pubic symphysis was 27.7 ± 4.5 mm, the posterior angle of the bladder was 122.7 ± 18.9°, the vertical distance from the rectal ampulla to the posterior inferior edge of pubic symphysis was 18.5 ± 4.6 mm, and the mean area of hiatus of the levator ani muscle was 22.1 ± 6.0 cm 2 . The mean posterior angle of the bladder on Valsalva was 159.3 ± 23.1°, and the mean urethral rotation angle was 67.2 ± 21.4°. Conclusions The 4D pelvic floor ultrasound is a reliable method in evaluating preoperational morphological characteristics of patients with SUI. With the help of the 4D pelvic floor ultrasound, the individualized treatment regimen can be developed and, more importantly, the inappropriate surgical decision can be avoided.
    Type of Medium: Online Resource
    ISSN: 2296-875X
    URL: Article
    DOI: 10.3389/fsurg.2023.1126293
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2773823-1
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  • 7
    Online Resource
    Online Resource
    On‐Site Production of Dilute H 2 O 2 with Zinc–Air Battery
    Wiley ; 2022
    In:  Advanced Materials Technologies Vol. 7, No. 3 ( 2022-03)
    Details
    In: Advanced Materials Technologies, Wiley, Vol. 7, No. 3 ( 2022-03)
    Abstract: Hydrogen peroxide (H 2 O 2 ) is extensively applied in environmental remediation, disinfection, bleaching, and so on. Two‐electron oxygen reduction reaction for synthesizing H 2 O 2 is the most promising alternative to the traditional energy‐intensive anthraquinone process. Existing strategies for electrocatalytic synthesis of H 2 O 2 generally proceed well in alkaline electrolytes. But environmental application demands the reaction to take place in a broad pH range, especially in acidic medium. Here a zinc‐air battery technology is developed for on‐site production of H 2 O 2 in alkaline, neutral, and acidic conditions. A key component of the battery is the tubular cathode fabricated by partially oxidized carbon nanotubes self‐assembled on the substrate of nickel foam. The battery exhibits an unusual 2e − discharge property and achieves an appreciable H 2 O 2 accumulation (215.1 µmol, 497 ppm, 162.5 mg L −1 h −1 ) in acidic solution within 3 h, which is among the highest value ever been reported through electrosynthesis. Excitingly, the battery coupled with UV light demonstrates a promising application in water purification, which enables rapid degradation of model pollutants and actual pollutants ranging from municipal sewage to dye and pesticide wastewaters. Furthermore, this water treatment technology can be self‐powered, as the battery in the system generates the power that is available to drive UV lights.
    Type of Medium: Online Resource
    ISSN: 2365-709X , 2365-709X
    URL: Issue
    URL: Article
    DOI: 10.1002/admt.v7.3
    DOI: 10.1002/admt.202100708
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2850995-X
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  • 8
    Online Resource
    Online Resource
    Cytoplasmic Accumulation of Histones Induced by BET Inhibition Protects Cells from C9orf72 Poly(PR)‐Induced Cell Death
    Wiley ; 2024
    In:  Advanced Biology
    Details
    In: Advanced Biology, Wiley
    Abstract: Repeat dipeptides such as poly(proline‐arginine) (polyPR) are generated from the hexanucleotide GGGGCC repeat expansions in the C9orf72 gene. These dipeptides are often considered as the genetic cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In the study, fluorescein isothiocyanate (FITC) labeled PR20 is used to investigate PR20‐induced cell death. The findings reveal that the cell death induced by PR20 is dependent on its nuclear distribution and can be blocked by a nuclear import inhibitor called importazole. Further investigation reveals that BRD4 inhibitors, such as JQ‐1 and I‐BET762, restrict cytoplasmic localization of PR20, thereby reducing its cytotoxic effect. Mechanistically, the inhibition of BRD4 leads to an increase in the expression of numerous histones, resulting in the accumulation of histones in the cytoplasm. These cytoplasmic histones associate with PR20 and limit its distribution within the nucleus. Notably, the ectopic expression of histones alone is enough to confer protection to cells treated with PR20. In addition, phenylephrine (PE) induces cellular hypertrophy and cytoplasmic distribution of histone, which also helps protect cells from PR20‐induced cell death. The research suggests that temporarily inducing the presence of cytoplasmic histones may alleviate the neurotoxic effects of dipeptide repeat proteins.
    Type of Medium: Online Resource
    ISSN: 2701-0198 , 2701-0198
    URL: Article
    DOI: 10.1002/adbi.202300334
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 3027224-5
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  • 9
    Online Resource
    Online Resource
    Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion
    Springer Science and Business Media LLC ; 2023
    In:  Oncogenesis Vol. 12, No. 1 ( 2023-11-20)
    Details
    In: Oncogenesis, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2023-11-20)
    Abstract: Although the transcriptional regulation of the programmed death ligand 1 (PD-L1) promoter has been extensively studied, the transcription factor residing in the PD-L1 super-enhancer has not been comprehensively explored. Through saturated CRISPR-Cas9 screening of the core region of the PD-L1 super-enhancer, we have identified a crucial genetic locus, referred to as locus 22, which is essential for PD-L1 expression. Locus 22 is a potential binding site for NFE2:MAF transcription factors. Although genetic silencing of NRF2 (NFE2L2) did not result in a reduction of PD-L1 expression, further analysis reveals that MAFG and NFE2L1 (NRF1) play a critical role in the expression of PD-L1. Importantly, lipopolysaccharides (LPS) as the major component of intratumoral bacteria could greatly induce PD-L1 expression, which is dependent on the PD-L1 super-enhancer, locus 22, and NFE2L1/MAFG. Mechanistically, genetic modification of locus 22 and silencing of MAFG greatly reduce BRD4 binding and loop formation but have minimal effects on H3K27Ac modification. Unlike control cells, cells with genetic modification of locus 22 and silencing of NFE2L1/MAFG failed to escape T cell-mediated killing. In breast cancer, the expression of MAFG is positively correlated with the expression of PD-L1. Taken together, our findings demonstrate the critical role of locus 22 and its associated transcription factor NFE2L1/MAFG in super-enhancer– and LPS-induced PD-L1 expression. Our findings provide new insight into understanding the regulation of PD-L1 transcription and intratumoral bacteria-mediated immune evasion.
    Type of Medium: Online Resource
    ISSN: 2157-9024
    URL: Article
    DOI: 10.1038/s41389-023-00500-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2674437-5
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  • 10
    Online Resource
    Online Resource
    Bacterial extracellular vesicles: A position paper by the Microbial Vesicles Task Force of the Chinese Society for Extracellular Vesicles (3/2023)
    Wiley ; 2023
    In:  Interdisciplinary Medicine Vol. 1, No. 3 ( 2023-07)
    Details
    In: Interdisciplinary Medicine, Wiley, Vol. 1, No. 3 ( 2023-07)
    Type of Medium: Online Resource
    ISSN: 2832-6245 , 2832-6245
    URL: Issue
    URL: Article
    DOI: 10.1002/inmd.v1.3
    DOI: 10.1002/inmd.12046
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 3158335-0
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