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  • Hindawi Limited  (12)
  • Wu, Meng  (12)
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  • Hindawi Limited  (12)
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  • 1
    Online Resource
    Online Resource
    DDTC Suppresses Ovarian Cancer Development via the PI3K/AKT/mTOR Signaling Pathway
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-8-8), p. 1-11
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-8-8), p. 1-11
    Abstract: In prior research, 6,12-diphenyl-3,9-diazatetraasterane-1, 5, 7, 11-tetracarboxylate (DDTC) has been shown to be an effective inhibitor of the growth of the SKOV3 and A2780 ovarian cancer (OC) cell lines. Flow cytometry analyses indicated that DDTC was able to suppress P-CNA expression at the protein level within OC cells, while RNA-seq indicated that DDTC treatment was associated with marked changes in gene expression profiles within A2780 cells. Molecular docking analyses suggested that DDTC has the potential to readily dock with key signaling proteins including PI3K, AKT, and mTOR. In line with these findings, DDTC treatment inhibited the growth of xenograft tumors in a mouse model system. Such treatment was also associated with reduced p-PI3K/PI3K, p-AKT/AKT, p-mTOR/mTOR, and CyclinD1 (CCND1) expressions and with the increased expression of PTEN in vitro and in vivo. Together, these results suggest that DDTC is capable of readily inhibiting OC development at least in part via targeting and modulating signaling via the PI3K/AKT/mTOR axis.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/1941077
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 2
    Online Resource
    Online Resource
    Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats
    Hindawi Limited ; 2018
    In:  Journal of Diabetes Research Vol. 2018 ( 2018-10-14), p. 1-13
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2018 ( 2018-10-14), p. 1-13
    Abstract: Spironolactone (SPR) has been shown to protect diabetic cardiomyopathy (DCM), but the specific mechanisms are not fully understood. Here, we determined the cardioprotective role of SPR in diabetic mice and further explored the potential mechanisms in both in vivo and in vitro models. Streptozotocin- (STZ-) induced diabetic rats were used as the in vivo model. After the onset of diabetes, rats were treated with either SPR (STZ + SPR) or saline (STZ + NS) for 12 weeks; nondiabetic rats were used as controls (NDCs). In vitro, H9C2 cells were exposed to aldosterone, with or without SPR. Cardiac structure was investigated with transmission electron microscopy and pathological examination; immunohistochemistry was performed to detect nitrotyrosine, collagen-1, TGF- β 1, TNF- α , and F4/80 expression; and gene expression of markers for oxidative stress, inflammation, fibrosis, and energy metabolism was detected. Our results suggested that SPR attenuated mitochondrial morphological abnormalities and sarcoplasmic reticulum enlargement in diabetic rats. Compared to the STZ + NS group, cardiac oxidative stress, fibrosis, inflammation, and mitochondrial dysfunction were improved by SPR treatment. Our study showed that SPR had cardioprotective effects in diabetic rats by ameliorating mitochondrial dysfunction and reducing fibrosis, oxidative stress, and inflammation. This study, for the first time, indicates that SPR might be a potential treatment for DCM.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2018/9232065
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2711897-6
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  • 3
    Online Resource
    Online Resource
    The Local and Global Existence of Solutions for a Generalized Camassa-Holm Equation
    Hindawi Limited ; 2012
    In:  Abstract and Applied Analysis Vol. 2012 ( 2012), p. 1-26
    Details
    In: Abstract and Applied Analysis, Hindawi Limited, Vol. 2012 ( 2012), p. 1-26
    Abstract: A nonlinear generalization of the Camassa-Holm equation is investigated. By making use of the pseudoparabolic regularization technique, its local well posedness in Sobolev space H S ( R ) with s 〉 3 / 2 is established via a limiting procedure. Provided that the initial value u 0 satisfies the sign condition and u 0 ∈ H s ( R )   ( s 〉 3 / 2 ) , it is shown that there exists a unique global solution for the equation in space C ( [ 0 , ∞ ) ; H s ( R ) ) ∩ C 1 ( [ 0 , ∞ ) ; H s − 1 ( R ) ) .
    Type of Medium: Online Resource
    ISSN: 1085-3375 , 1687-0409
    URL: Article
    DOI: 10.1155/2012/532369
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2064801-7
    SSG: 17,1
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  • 4
    Online Resource
    Online Resource
    Exposure to environmental tobacco smoke during pregnancy and infancy increased the risk of upper respiratory tract infections in infants: A birth cohort study in Wuhan, China
    Hindawi Limited ; 2021
    In:  Indoor Air Vol. 31, No. 3 ( 2021-05), p. 673-681
    Details
    In: Indoor Air, Hindawi Limited, Vol. 31, No. 3 ( 2021-05), p. 673-681
    Type of Medium: Online Resource
    ISSN: 0905-6947 , 1600-0668
    URL: Issue
    URL: Article
    DOI: 10.1111/ina.v31.3
    DOI: 10.1111/ina.12761
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2028169-9
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  • 5
    Online Resource
    Online Resource
    Using electroencephalogram to continuously discriminate feelings of personal thermal comfort between uncomfortably hot and comfortable environments
    Hindawi Limited ; 2020
    In:  Indoor Air Vol. 30, No. 3 ( 2020-05), p. 534-543
    Details
    In: Indoor Air, Hindawi Limited, Vol. 30, No. 3 ( 2020-05), p. 534-543
    Type of Medium: Online Resource
    ISSN: 0905-6947 , 1600-0668
    URL: Issue
    URL: Article
    DOI: 10.1111/ina.v30.3
    DOI: 10.1111/ina.12644
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2028169-9
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  • 6
    Online Resource
    Online Resource
    The Analysis of Potential Diagnostic and Therapeutic Targets for the Occurrence and Development of Gastric Cancer Based on Bioinformatics
    Hindawi Limited ; 2022
    In:  Computational and Mathematical Methods in Medicine Vol. 2022 ( 2022-6-17), p. 1-20
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2022 ( 2022-6-17), p. 1-20
    Abstract: Objective. Gastric cancer is among the most common malignant tumors of the digestive system. This study explored the molecular mechanisms and potential therapeutic targets for gastric cancer occurrence and progression using bioinformatics. Methods. The gastric cancer microarray dataset was downloaded from the Gene Expression Omnibus (GEO) database. The R package was used for data mining and screening differentially expressed genes (DEGs). Gene Ontology (GO) analysis and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway analysis were performed using the Database for Annotation, Visualization, and Integrated Discovery (DAVID). Based on the protein-protein interaction (PPI) network analysis, core targets and core subsets were screened. Then, the relationship between the expression level of the core genes and the prognosis of gastric cancer patients was analyzed using the Gene Expression Profiling Interactive Analysis (GEPIA) database. Results. Using the GSE19826 and GSE54129 datasets, a total of 550 DEGs were identified, including 248 upregulated and 302 downregulated genes. GO and KEGG analyses showed that the upregulated DEGs were mainly enriched in the extracellular matrix (ECM) organization of the biological process (BP), the collagen-containing ECM of cellular component (CC), and the ECM structural constituent of molecular function (MF). DEGs were also enriched in human papillomavirus infections, the focal adhesion pathway, PI3K-Akt signaling pathway, and among others. The downregulated DEGs were mainly enriched in digestion, basal part of the cell, and aldo-keto reductase (NADP) activity. And the above pathways were enriched primarily in the metabolism of xenobiotics by cytochrome P450, drug metabolism-cytochrome P450, and retinol metabolism. Five core genes, including COL1A2, COL3A1, BGN, FN1, and VCAN, were significantly highly expressed in gastric cancer patients and were associated with poor prognosis. Conclusion. This study identified new potential molecular targets closely related to gastric cancer occurrence and development via mining public data using bioinformatics analysis methods.
    Type of Medium: Online Resource
    ISSN: 1748-6718 , 1748-670X
    URL: Article
    DOI: 10.1155/2022/4321466
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2256917-0
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  • 7
    Online Resource
    Online Resource
    Improvement in Isolation and Identification of Mouse Oogonial Stem Cells
    Hindawi Limited ; 2016
    In:  Stem Cells International Vol. 2016 ( 2016), p. 1-10
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-10
    Abstract: Female germline stem cells (FGSCs) or oogonial stem cells (OSCs) have the capacity to generate newborn oocytes and thus open a new door to fight ovarian aging and female infertility. However, the production and identification of OSCs are difficult for investigators. Rare amount of these cells in the ovary results in the failure of the acquisition of OSCs. Furthermore, the oocyte formation by OSCs in vivo was usually confirmed using tissue sections by immunofluorescence or immunohistochemistry in previous studies. STO or MEF feeder cells are derived from mouse, not human. In our study, we modified the protocol. The cells were digested from ovaries and cultured for 2-3 days and then were purified by magnetic-activated cell sorting (MACS). The ovaries and fetus of mice injected with EGFP-positive OSCs were prepared and put on the slides to directly visualize oocyte and progeny formation under microscope. Additionally, the human umbilical cord mesenchymal stem cells (hUC-MSCs) were also used as feeder cells to support the proliferation of OSCs. The results showed that all the modified procedures can significantly improve and facilitate the generation and characterization of OSCs, and hUC-MSCs as feeder will be useful for isolation and proliferation of human OSCs avoiding contamination from mouse.
    Type of Medium: Online Resource
    ISSN: 1687-966X , 1687-9678
    URL: Article
    DOI: 10.1155/2016/2749461
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2573856-2
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  • 8
    Online Resource
    Online Resource
    Dynamic Optimization Method of Wireless Network Routing Based on Deep Learning Strategy
    Hindawi Limited ; 2022
    In:  Mobile Information Systems Vol. 2022 ( 2022-7-30), p. 1-11
    Details
    In: Mobile Information Systems, Hindawi Limited, Vol. 2022 ( 2022-7-30), p. 1-11
    Abstract: Wireless sensor network is a network that integrates sensor technology, computer technology, information processing technology, and communication technology. This paper aims to study how to analyze and study the routing optimization of wireless sensor network based on deep learning and describe the neural network. This paper puts forward the problem of routing optimization, which is based on the dynamic programming of wireless sensor network, and then elaborates around its concept and related algorithms and designs and analyzes the case of wireless sensor network optimization. Through the comparative analysis of the five algorithms in computer simulation, although the average network delay performance of DPER reached 0.47 s, it could effectively prolong the life cycle of the network. The DPER algorithm not only improves the network life but also improves the network energy utilization rate, shortens the average path length of the network, and reduces the standard deviation of the remaining energy of the node.
    Type of Medium: Online Resource
    ISSN: 1875-905X , 1574-017X
    URL: Article
    DOI: 10.1155/2022/4964672
    RVK:
    QA 10000
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2187808-0
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  • 9
    Online Resource
    Online Resource
    Methods to Measure the Network Path Connectivity
    Hindawi Limited ; 2020
    In:  Security and Communication Networks Vol. 2020 ( 2020-11-10), p. 1-10
    Details
    In: Security and Communication Networks, Hindawi Limited, Vol. 2020 ( 2020-11-10), p. 1-10
    Abstract: The functionalities, such as connectivity and communication capability of complex networks, are related to the number and length of paths between node pairs in the networks. In this paper, we propose a new path connectivity measure by considering the number and length of paths of the network (PCNL) to evaluate network path connectivity. By comparing the PCNL with the typical natural connectivity, we prove the effectiveness of the PCNL to measure the path connectivity of networks. Because of the importance of the shortest paths, we further propose the shortest paths connectivity measure (SPCNL) based on the number and length of the shortest paths. Then, we use edge-betweenness-based malicious attacks to study the relationship between the SPCNL and network topology in five types of networks. The results show that the SPCNLs of the networks have a significant corresponding relationship and similar changing trend with their network topology heterogeneities with the increase of the number of deleted edges. These findings mean that the SPCNL is positively correlated with the heterogeneity of the network topology, which provides a new perspective for designing complex networks with high path connectivity.
    Type of Medium: Online Resource
    ISSN: 1939-0122 , 1939-0114
    URL: Article
    DOI: 10.1155/2020/8836590
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2415104-X
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  • 10
    Online Resource
    Online Resource
    Immunoregulation of NKT Cells in Systemic Lupus Erythematosus
    Hindawi Limited ; 2015
    In:  Journal of Immunology Research Vol. 2015 ( 2015), p. 1-8
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Abstract: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with different variety of clinical manifestations. Natural killer T (NKT) cells are innate lymphocytes that play a regulatory role during broad range of immune responses. A number of studies demonstrated that the quantity and quality of invariant NKT (iNKT) cells showed marked defects in SLE patients in comparison to healthy controls. This finding suggests that iNKT cells may play a regulatory role in the occurrence and development of this disease. In this review, we mainly summarized the most recent findings about the behavior of NKT cells in SLE patients and mouse models, as well as how NKT cells affect the proportion of T helper cells and the production of autoreactive antibodies in the progress of SLE. This will help people better understand the role of NKT cells in the development of SLE and improve the therapy strategy.
    Type of Medium: Online Resource
    ISSN: 2314-8861 , 2314-7156
    URL: Article
    DOI: 10.1155/2015/206731
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2817541-4
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