In:
New Journal of Chemistry, Royal Society of Chemistry (RSC), Vol. 46, No. 15 ( 2022), p. 6932-6939
Abstract:
The intrinsic features of tumors often give rise to unsatisfactory outcomes of photothermal treatment (PTT). Remarkably, the tumor microenvironment (TME) with abundant antioxidants, elevated hydrogen peroxide (H 2 O 2 ), and low pH has proven to be a tremendous obstacle for tumor treatment. Therefore, developing an effective photosensitizer that can respond to both NIR radiation and TME is imperative but remains a challenge. Here, we explore a molybdenum-based polyoxometalate (Na 15 [Mo VI 126 -Mo V 28 O 462 H 14 (H 2 O) 70 ]·400H 2 O, [Mo 154 ]) as a photosensitizer for TME-manipulated PTT enhancement because of the following features. Firstly, the 808 nm absorption of [Mo 154 ] can be increased via pH-induced aggregation; secondly, due to the unique multi-electron property, [Mo 154 ] can deplete cysteine and reactive oxygen species (ROS) via redox reactions; thirdly, reduced [Mo 154 ] ([rMo 154 ]) can further improve the 808 nm absorption by promoting the transition from Mo( vi ) to Mo( v ). Consequently, [Mo 154 ] can overcome several obstacles in TME and thus improve the PTT efficiency by synergizing the effects of pH-induced aggregation, cysteine reduction and depletion, and free-radical scavenging. In addition to providing a promising photosensitizer for PTT, this finding extends the application of molybdenum-based polyoxometalates in the biomedical field.
Type of Medium:
Online Resource
ISSN:
1144-0546
,
1369-9261
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
1472933-7
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