In:
Journal of Cellular and Molecular Medicine, Wiley, Vol. 23, No. 2 ( 2019-02), p. 1363-1374
Abstract:
Lysyl oxidase‐like 2 ( LOXL 2) has shown to promote metastasis and poor prognosis in hepatocellular carcinoma ( HCC ). Also, we have previously reported that vasculogenic mimicry ( VM ) is associated with invasion, metastasis and poor survival in HCC patients. In the present study, we investigated molecular function of LOXL 2 in HCC and VM . We used the immunohistochemical and CD 31/periodic acid‐Schiff double staining to detect the relationship between LOXL 2 and VM formation. We performed the gain and loss of function studies and analysed the migratory, invasion and tube formation in HCC cell lines. We analysed the function of LOXL 2 in VM formation and HCC metastasis both in vitro and in vivo. We have showed that LOXL 2 was overexpression in HCC and was positively correlated with tumour grade, metastasis, VM formation and poor survival in 201 HCC patients. Secondly, our studies have showed that LOXL 2 overexpression in HCC cells significantly promoted migration, invasion and tube formation. Finally, we found that LOXL 2 may increase SNAIL expression, thereby enabling VM . Our study indicated that LOXL 2 may promote VM formation and tumour metastasis by collaborating with SNAIL in HCC . What's more, the overexpression of LOXL 2 indicated a poor prognosis in HCC patients.
Type of Medium:
Online Resource
ISSN:
1582-1838
,
1582-4934
DOI:
10.1111/jcmm.2019.23.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2076114-4
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