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  • SAGE Publications  (5)
  • Wu, Lei  (5)
  • 1
    Online Resource
    Online Resource
    Natural products for chronic cough : Text mining the East Asian historical literature for future therapeutics
    SAGE Publications ; 2015
    In:  Chronic Respiratory Disease Vol. 12, No. 3 ( 2015-08), p. 204-211
    Details
    In: Chronic Respiratory Disease, SAGE Publications, Vol. 12, No. 3 ( 2015-08), p. 204-211
    Abstract: Chronic cough is a significant health burden. Patients experience variable benefits from over the counter and prescribed products, but there is an unmet need to provide more effective treatments. Natural products have been used to treat cough and some plant compounds such as pseudoephedrine from ephedra and codeine from opium poppy have been developed into drugs. Text mining historical literature may offer new insight for future therapeutic development. We identified natural products used in the East Asian historical literature to treat chronic cough. Evaluation of the historical literature revealed 331 natural products used to treat chronic cough. Products included plants, minerals and animal substances. These natural products were found in 75 different books published between AD 363 and 1911. Of the 331 products, the 10 most frequently and continually used products were examined, taking into consideration findings from contemporary experimental studies. The natural products identified are promising and offer new directions in therapeutic development for treating chronic cough.
    Type of Medium: Online Resource
    ISSN: 1479-9731 , 1479-9731
    URL: Article
    DOI: 10.1177/1479972315583043
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2222367-8
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  • 2
    Online Resource
    Online Resource
    Comparing the performance of traditional non-treponemal tests on syphilis and non-syphilis serum samples
    SAGE Publications ; 2013
    In:  International Journal of STD & AIDS Vol. 24, No. 12 ( 2013-12), p. 919-925
    Details
    In: International Journal of STD & AIDS, SAGE Publications, Vol. 24, No. 12 ( 2013-12), p. 919-925
    Abstract: The goal of the present study was to determine the performance of two traditional non-treponemal tests for syphilis. Syphilis sera ( n = 209) included different stages of disease, and control sera ( n = 247) were from patients with tumours, leprosy, systemic lupus erythematosus, hepatitis, pregnant women and healthy individuals. Treponema pallidum ELISA, Treponema pallidum particle agglutination and rapid treponema-specific tests were used as gold standards. Rapid plasma reagin or toluidine red unheated serum test had a sensitivity and specificity of over 95%. False-negative reactions of rapid plasma reagin and toluidine red unheated serum test were observed mainly in primary and latent syphilis cases, and false-positive reactions were present in systemic lupus erythematosus, hepatitis-infected patients. Overall, both non-treponemal tests had high sensitivities and specificities making the assays attractive as screening tests for syphilis. When examined on WHO reference serum samples and based on lower limits of detection, non-treponemal tests were less sensitive than treponema-specific tests.
    Type of Medium: Online Resource
    ISSN: 0956-4624 , 1758-1052
    URL: Article
    DOI: 10.1177/0956462413491399
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2009782-7
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  • 3
    Online Resource
    Online Resource
    Understanding Flex-Route Transit Adoption from a Stage of Change Perspective
    SAGE Publications ; 2023
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2677, No. 6 ( 2023-06), p. 743-758
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2677, No. 6 ( 2023-06), p. 743-758
    Abstract: Given the potential benefits of flex-route transit for the environment and traffic congestion, many cities have goals for diffusing flex-route transit. However, previous studies have focused on practical experience, strategic planning, and operational planning of flex-route transit. Few studies have identified the determinants of flex-route transit adoption. This study aims to address the effect of demographic characteristics and psychological factors on flex-route transit adoption by employing a stage of change framework. First, the transtheoretical model is applied to divide respondents into five ordered stages (i.e., Precontemplation, Contemplation, Preparation, Action, and Maintenance). Second, a survey was conducted in Beijing, China, using an online platform to obtain the demographic characteristics and measurement items of the respondents in the five ordered stages. Then, a structural equation model is applied to quantify psychological factors. In addition, the partial proportional odds (PPO) model is employed to estimate the best model and identify the determinants of flex-route transit adoption. Finally, an elasticity analysis is conducted to uncover the effect of determinants on flex-route transit adoption in the five ordered stages. The results suggest that the PPO model has the best fit and validity. The model reveals the significant implications of psychological factors and demographic characteristics for transport policy in various stages. These findings show that, regardless of the initial stage, interventions concentrating on psychological factors and demographic characteristics appear to have the potential to transfer the stage of individuals from one to another. To make policies as effective as possible for promoting flex-route transit adoption, the targeted interventions should be complemented in the specific stage.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.1177/03611981221150244
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2403378-9
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  • 4
    Online Resource
    Online Resource
    Molecular aspects of β, β-carotene-9′, 10′-oxygenase 2 in carotenoid metabolism and diseases
    SAGE Publications ; 2016
    In:  Experimental Biology and Medicine Vol. 241, No. 17 ( 2016-11), p. 1879-1887
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 241, No. 17 ( 2016-11), p. 1879-1887
    Abstract: Carotenoids, the carotenes and xanthophylls, are essential components in human nutrition. β, β-carotene-9′, 10′-oxygenase 2 (BCO2), also named as β, β-carotene-9′, 10'-dioxygenase 2 (BCDO2) catalyzes the asymmetrical cleavage of carotenoids, whereas β, β-carotene-15, 15′-monooxygenase (BCMO1) conducts the symmetrical cleavage of pro-vitamin A carotenoids into retinoid. Unlike BCMO1, BCO2 has a broader substrate specificity and has been considered an alternative way to produce vitamin A. In contrast to BCMO1, a cytoplasmic protein, BCO2 is located in the inner mitochondrial membrane. The difference in cellular compartmentalization may reflect the different substrate specificity and physiological functions with respect to BCMO1 and BCO2. The BCO2 gene mutations are proven to be associated with yellow color of skin and fat tissue and milk in livestock. Mutation in intron 2 of BCO2 gene is also supposed to be related to the expression of IL-18, a pro-inflammatory cytokine associated with obesity, cardiovascular diseases, and type 2 diabetes. Further, BCO2 is associated with the development of mitochondrial oxidative stress, macular degeneration, anemia, and hepatic steatosis. This review of the literature will mostly address recent updates regarding the role of BCO2 in carotenoid metabolism, and discuss the potential impacts of BCO2 protein and the mutations in mammalian diseases.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370216657900
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    On dynamic performance estimation of fault-prone Infrastructure-as-a-Service clouds
    SAGE Publications ; 2017
    In:  International Journal of Distributed Sensor Networks Vol. 13, No. 7 ( 2017-07), p. 155014771771851-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 13, No. 7 ( 2017-07), p. 155014771771851-
    Abstract: The cloud computing paradigm enables elastic resources to be scaled at run time satisfy customers’ demand. Cloud computing provisions on-demand service to users based on a pay-as-you-go manner. This novel paradigm enables cloud users or tenant users to afford computational resources in the form of virtual machines as utilities, just like electricity, instead of paying for and building computing infrastructures by their own. Performance usually specified through service level agreement performance commitment of clouds is one of key research challenges and draws great research interests. Thus, performance issues of cloud infrastructures have been receiving considerable interest by both researchers and practitioners as a prominent activity for improving cloud quality. This work develops an analytical approach to dynamic performance modeling and trend prediction of fault-prone Infrastructure-as-a-Service clouds. The proposed analytical approach is based on a time-series and stochastic-process-based model. It is capable of predicting the expected system responsiveness and request rejection rate under variable load intensities, fault frequencies, multiplexing abilities, and instantiation processing times. A comparative study between theoretical and measured performance results through a real-world campus cloud is carried out to prove the correctness and accuracy of the proposed prediction approach.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1177/1550147717718514
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2192922-1
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