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  • Wiley  (20)
  • Wu, Jie  (20)
  • 1
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    Online Resource
    Circulating microRNAs in association with pancreatic cancer risk within 5 years
    Wiley ; 2024
    In:  International Journal of Cancer Vol. 155, No. 3 ( 2024-08), p. 519-531
    Details
    In: International Journal of Cancer, Wiley, Vol. 155, No. 3 ( 2024-08), p. 519-531
    Abstract: Early detection is critical for improving pancreatic cancer prognosis. Our study aims to identify circulating microRNAs (miRNAs) associated with pancreatic cancer risk. The two‐stage study used plasma samples collected ≤5 years prior to cancer diagnosis, from case–control studies nested in five prospective cohort studies. The discovery stage included 185 case–control pairs from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Replication stage samples comprised 277 pairs from Shanghai Women's Health Study/Shanghai Men's Health Study, Southern Community Cohort Study, and Multiethnic Cohort Study. Seven hundred and ninety‐eight miRNAs were measured using the NanoString nCounter Analysis System. Odds ratios (OR) and 95% confidence intervals (CI) for per 10% change in miRNAs in association with pancreatic cancer risk were derived from conditional logistic regression analysis in discovery and replication studies, separately, and then meta‐analyzed. Stratified analysis was conducted by age at diagnosis ( 〈 65/≥65 years) and time interval between sample collection and diagnosis (≤2/ 〉 2 years). In the discovery stage, 120 risk associated miRNAs were identified at p 〈 .05. Three were validated in the replication stage: hsa‐miR‐199a‐3p/hsa‐miR‐199b‐3p, hsa‐miR‐767‐5p, and hsa‐miR‐191‐5p, with respective ORs (95% CI) being 0.89 (0.84–0.95), 1.08 (1.02–1.13), and 0.90 (0.85–0.95). Five additional miRNAs, hsa‐miR‐640, hsa‐miR‐874‐5p, hsa‐miR‐1299, hsa‐miR‐22‐3p, and hsa‐miR‐449b‐5p, were validated among patients diagnosed at ≥65 years, with OR (95% CI) of 1.23 (1.09–1.39), 1.33 (1.16–1.52), 1.25 (1.09–1.43), 1.28 (1.12–1.46), 0.76 (0.65–0.89), and 1.22 (1.07–1.39), respectively. The miRNA targets were enriched in pancreatic carcinogenesis/progression‐related pathways. Our study suggests that circulating miRNAs may identify individuals at high risk for pancreatic cancer ≤5 years prior to diagnosis, indicating its potential utility in cancer screening and surveillance.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v155.3
    DOI: 10.1002/ijc.34956
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 2
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    Associations of leukocyte telomere length with body anthropometric indices and weight change in chinese women
    Wiley ; 2013
    In:  Obesity Vol. 21, No. 12 ( 2013-12), p. 2582-2588
    Details
    In: Obesity, Wiley, Vol. 21, No. 12 ( 2013-12), p. 2582-2588
    Abstract: Objective: This study evaluated associations of telomere length with various anthropometric indices of general and abdominal obesity, as well as weight change. Design and Methods: The study included 2,912 Chinese women aged 40‐70 years. Monochrome multiplex quantitative polymerase chain reaction was applied to measure relative telomere length. Results: Telomere length was inversely associated with body mass index (BMI), waist circumference, waist‐to‐height ratio, weight, and hip circumference ( P trend = 0.005, 0.004, 0.004, 0.010, and 0.026, respectively), but not waist‐to‐hip ratio ( P trend = 0.116) or height ( P trend = 0.675). Weight change since age 50 was further evaluated among women over age 55. Women who maintained their weight within ±5% since age 50, particularly within a normal range (BMI = 18.5‐24.9 kg/m 2 ), or reduced their weight from overweight (BMI = 25‐29.9 kg/m 2 ) or obesity (BMI ≥30 kg/m 2 ) to normal range, had a longer mean of current telomere length than women who gained weight since age 50 ( P trend = 0.025), particularly those who stayed in obesity or gained weight from normal range or overweight to obesity ( P = 0.023). Conclusion: Our findings show that telomere shortening is associated with obesity and that maintaining body weight within a normal range helps maintain telomere length.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Issue
    URL: Article
    DOI: 10.1002/oby.v21.12
    DOI: 10.1002/oby.20321
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2027211-X
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  • 3
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    Prospective study of oral microbiome and gastric cancer risk among Asian, African American and European American populations
    Wiley ; 2022
    In:  International Journal of Cancer Vol. 150, No. 6 ( 2022-03-15), p. 916-927
    Details
    In: International Journal of Cancer, Wiley, Vol. 150, No. 6 ( 2022-03-15), p. 916-927
    Abstract: What's new? Previous studies of oral microbiome and gastric cancer risk were mainly conducted in Asians and were limited by retrospective designs and low taxonomic resolutions. This study is the first multi‐racial study to prospectively investigate the relationship between oral microbiome and gastric cancer risk, utilizing shotgun metagenomic sequencing to assess the microbiome in pre‐diagnostic buccal samples. Decreased overall microbial richness, altered abundance of several microbial taxa, and multiple microbial functional markers were found to be associated with gastric cancer risk. The study supports the hypothesis that oral microbiota may play a role in gastric cancer etiology.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v150.6
    DOI: 10.1002/ijc.33847
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 4
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    Genome‐wide association studies for loin muscle area, loin muscle depth and backfat thickness in DLY pigs
    Wiley ; 2024
    In:  Animal Genetics Vol. 55, No. 1 ( 2024-02), p. 134-139
    Details
    In: Animal Genetics, Wiley, Vol. 55, No. 1 ( 2024-02), p. 134-139
    Abstract: This study aimed at identifying genes associated with loin muscle area (LMA), loin muscle depth (LMD) and backfat thickness (BFT). We performed single‐trait and multi‐trait genome‐wide association studies (GWASs) after genotyping 685 Duroc × (Landrace × Yorkshire) (DLY) pigs using the Geneseek Porcine 50K SNP chip. In the single‐trait GWASs, we identified two, eight and two significant SNPs associated with LMA, LMD and BFT, respectively, and searched genes within the 1 Mb region near the significant SNPs with relevant functions as candidate genes. Consequently, we identified one ( DOCK5 ), three ( PID1 , PITX2 , ELOVL6 ) and three ( CCR1 , PARP14 , CASR ) promising candidate genes for LMA, LMD and BFT, respectively. Moreover, the multi‐trait GWAS identified four significant SNPs associated with the three traits. In conclusion, the GWAS analysis of LMA, LMD and BFT in a DLY pig population identified several associated SNPs and candidate genes, further deepening our understanding of the genetic basis of these traits, and they may be useful for marker‐assisted selection to improve the three traits in DLY pigs.
    Type of Medium: Online Resource
    ISSN: 0268-9146 , 1365-2052
    URL: Issue
    URL: Article
    DOI: 10.1111/age.v55.1
    DOI: 10.1111/age.13386
    Language: English
    Publisher: Wiley
    Publication Date: 2024
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    SSG: 22
    SSG: 12
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  • 5
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    Light‐Promoted Organic Transformations Utilizing Carbon‐Based Gas Molecules as Feedstocks
    Wiley ; 2021
    In:  Angewandte Chemie Vol. 133, No. 35 ( 2021-08-23), p. 19098-19128
    Details
    In: Angewandte Chemie, Wiley, Vol. 133, No. 35 ( 2021-08-23), p. 19098-19128
    Abstract: Carbon‐based gas molecules are readily available feedstocks and are widely used in industry as building blocks or fuels. However, their application in the synthesis of fine chemicals has been hampered due to operational complexity, poor reaction efficiency and selectivity. Recent development of photoredox‐promoted transformations using such gaseous reagents has received considerable attention from the synthetic community. In this review, efforts in developing light‐promoted organic transformations using carbon‐based natural gases as C1 or C2 feedstocks and to overcome the associated challenges are briefly summarized.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v133.35
    DOI: 10.1002/ange.202010710
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 6
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    Long‐term soy consumption and tumor tissue MicroRNA and gene expression in triple‐negative breast cancer
    Wiley ; 2016
    In:  Cancer Vol. 122, No. 16 ( 2016-08-15), p. 2544-2551
    Details
    In: Cancer, Wiley, Vol. 122, No. 16 ( 2016-08-15), p. 2544-2551
    Abstract: Soy food consumption may influence the risk and prognosis of breast cancer by altering the expression of cancer‐related microRNAs and genes.
    Type of Medium: Online Resource
    ISSN: 0008-543X , 1097-0142
    URL: Issue
    URL: Article
    DOI: 10.1002/cncr.v122.16
    DOI: 10.1002/cncr.29981
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1479932-7
    detail.hit.zdb_id: 2599218-1
    detail.hit.zdb_id: 2594979-2
    detail.hit.zdb_id: 1429-1
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  • 7
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    Dysmorphic erythrocytes are superior to hematuria for indicating non‐diabetic renal disease in type 2 diabetics
    Wiley ; 2016
    In:  Journal of Diabetes Investigation Vol. 7, No. 1 ( 2016-01), p. 115-120
    Details
    In: Journal of Diabetes Investigation, Wiley, Vol. 7, No. 1 ( 2016-01), p. 115-120
    Abstract: There are sparse and limited studies on erythrocyte morphology in renal biopsy identifying nephropathic patients among type 2 diabetics. The present study sought to clarify the predictive value of dysmorphic erythrocytes in type 2 diabetics with non‐diabetic renal disease and influences on hematuria. Materials and Methods We examined 198 patients with type 2 diabetes who underwent kidney biopsies between 2012 and 2013. Hematuria was defined as 〉 3 or 〉 10 red blood cells per high‐power field ( RBC s/hpf) in urine sediment. If 〉 80% of the erythrocytes were dysmorphic, glomerular hematuria was diagnosed. Clinical findings and predictive value of dysmorphic erythrocytes were compared between patients with hematuria ( n  = 19) and those without ( n  = 61). The potential risk factors for hematuria among diabetic nephropathy patients were also screened. Results There was a statistically significant difference between the diabetic nephropathy group and the non‐diabetic renal disease group (6.6 vs 16.8%; P  = 0.04) when the demarcation point of hematuria was 10  RBC s/hpf. When the definition of hematuria was based on an examination of urinary erythrocyte morphology, a marked difference was seen (3.3 vs 24.8%; P  〈   0.001). Glomerular hematuria showed high specificity and a positive predictive value (0.97 and 0.94, respectively) in non‐diabetic renal disease. A multivariate analysis showed that nephrotic syndrome was significantly associated with hematuria (odds ratio 3.636; P  = 0.034). Conclusions Dysmorphic erythrocytes were superior to hematuria for indicating non‐diabetic renal disease in type 2 diabetics. Nephrotic syndrome was an independent risk factor for hematuria.
    Type of Medium: Online Resource
    ISSN: 2040-1116 , 2040-1124
    URL: Issue
    URL: Article
    DOI: 10.1111/jdi.2016.7.issue-1
    DOI: 10.1111/jdi.12371
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2542077-X
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  • 8
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    Prospective study of plasma levels of coenzyme Q10 and lung cancer risk in a low‐income population in the Southeastern United States
    Wiley ; 2021
    In:  Cancer Medicine Vol. 10, No. 4 ( 2021-02), p. 1439-1447
    Details
    In: Cancer Medicine, Wiley, Vol. 10, No. 4 ( 2021-02), p. 1439-1447
    Abstract: Coenzyme Q10 (CoQ10) is a ubiquitous molecule in living organisms serving as a cofactor in energy production. Epidemiological studies have reported low CoQ10 levels being associated with an increased risk of various cancers. We conducted the first study to evaluate the association of CoQ10 concentrations with lung cancer risk. Methods A nested case‐control study including 201 lung cancer cases and 395 matched controls from the Southern Community Cohort Study was conducted. Plasma CoQ10 levels were measured using high‐performance liquid chromatography with photo‐diode array detection. Conditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between plasma CoQ10 levels and lung cancer risk. Results Plasma CoQ10 concentration was inversely associated with the risk of lung cancer. After adjusting for age, sex, race, and socioeconomic status, the OR (95% CI) comparing the third to first tertile was 0.57 (0.36–0.91, P for trend = 0.02). Further adjustments for smoking, alcohol, chronic obstructive pulmonary disease, and body mass index attenuated the point estimate slightly (OR = 0.60, 95% CI = 0.34–1.08, P for trend = 0.11), comparing third to first tertiles. Stratified analyses identified a significant inverse association between plasma CoQ10 levels and lung cancer risk in current smokers, but not in former/never smokers. The association was more evident in cases who were diagnosed within 1 year of blood draw than in cases diagnosed after 1 year. Conclusions Low plasma CoQ10 was significantly associated with increased lung cancer risk, particularly among current smokers. The stronger association seen shortly following the blood draw suggests that CoQ10 may be related to disease progression.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v10.4
    DOI: 10.1002/cam4.3637
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2659751-2
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  • 9
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    Association between sarcopenia and frailty in elderly patients with chronic kidney disease
    Wiley ; 2023
    In:  Journal of Cachexia, Sarcopenia and Muscle Vol. 14, No. 4 ( 2023-08), p. 1855-1864
    Details
    In: Journal of Cachexia, Sarcopenia and Muscle, Wiley, Vol. 14, No. 4 ( 2023-08), p. 1855-1864
    Abstract: Frailty and sarcopenia are prevalent in chronic kidney disease (CKD) populations and could increase the risk for adverse health outcomes. Few studies assess the correlation between frailty, sarcopenia and CKD in non‐dialysis patients. Therefore, this study aimed to determine frailty‐associated factors in elderly CKD stage I–IV patients, expected to early identify and intervene in the frailty of elderly CKD patients. Methods A total of 774 elderly CKD I–IV patients ( 〉 60 years of age) recruited from 29 clinical centers in China between March 2017 and September 2019 were included in this study. We established a Frailty Index (FI) model to evaluate frailty risk and verified the distributional property of FI in the study population. Sarcopenia was defined according to the criteria of the Asian Working Group for Sarcopenia 2019. Multinomial logistic regression analysis was used to assess the associated factors for frailty. Results Seven hundred seventy‐four patients (median age 67 years, 66.0% males) were included in this analysis, with a median estimated glomerular filtration rate of 52.8 mL/min/1.73 m 2 . The prevalence of sarcopenia was 30.6%. The FI exhibited a right‐skewed distribution. The age‐related slope of FI was 1.4% per year on a logarithmic scale ( r 2  = 0.706, 95% CI 0.9, 1.8, P   〈  0.001). The upper limit of FI was around 0.43. The FI was related to mortality (HR = 1.06, 95% CI 1.00, 1.12, P  = 0.041). Multivariate multinomial logistic regression analysis showed that sarcopenia, advanced age, CKD stage II–IV, low level of serum albumin and increased waist–hip ratio were significantly associated with high FI status, while advanced age and CKD stage III–IV were significantly associated with for median FI status. Moreover, the results from the subgroup were consistent with the leading results. Conclusions Sarcopenia was independently associated with an increased risk for frailty in elderly CKD I‐IV patients. Patients with sarcopenia, advanced age, high CKD stage, high waist–hip ratio and low serum albumin level should be assessed for frailty.
    Type of Medium: Online Resource
    ISSN: 2190-5991 , 2190-6009
    URL: Issue
    URL: Article
    DOI: 10.1002/jcsm.v14.4
    DOI: 10.1002/jcsm.13275
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2586864-0
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  • 10
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    T‐cell exhaustion interrelates with immune cytolytic activity to shape the inflamed tumor microenvironment
    Wiley ; 2020
    In:  The Journal of Pathology Vol. 251, No. 2 ( 2020-06), p. 147-159
    Details
    In: The Journal of Pathology, Wiley, Vol. 251, No. 2 ( 2020-06), p. 147-159
    Abstract: Direct quantification of exhausted T cells in human cancer is lacking, and its predictive value for checkpoint‐based treatment remains poorly investigated. We sought to systematically characterize the pan‐cancer landscape and molecular hallmarks of T‐cell dysfunction for the purpose of precision immunotherapy. Here, we defined a transcriptional signature for T‐cell exhaustion through analyzing differential gene expression between PD‐1‐high and PD‐1‐negative CD8 + T lymphocytes from primary non‐small cell lung cancer (NSCLC), followed by positive correlation tests with PDCD1 in TCGA lung carcinomas. A 78‐gene signature for exhausted CD8 + T cells (GET) was identified and validated to reflect dysfunctional immune state spanning different species and disease models. We discovered that GET estimation significantly correlated with intratumoral immune cytolytic activity (CYT) and T‐cell‐inflamed gene expression profile (GEP) across 30 solid tumor types. Miscellaneous tumor‐intrinsic and ‐extrinsic properties, in particular leukocyte proportions, genomic abnormalities, specific mutational signatures, and signaling pathways, were notably associated with GET levels. Furthermore, higher GET expression predicted an increased likelihood of clinical response to immune checkpoint inhibitors. These findings highlight the interrelation between T‐cell exhaustion and immune cytolytic activity at the pan‐cancer scale. The resulting inflamed tumor microenvironment may further crosstalk with other molecular and clinicopathological factors, which should be properly considered during immunotherapy biomarker development. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0022-3417 , 1096-9896
    URL: Issue
    URL: Article
    DOI: 10.1002/path.v251.2
    DOI: 10.1002/path.5435
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1475280-3
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