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  • SAGE Publications  (22)
  • Wu, Jianhua  (22)
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  • SAGE Publications  (22)
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  • 1
    Online Resource
    Online Resource
    Inhibition of Glutamine Uptake Improves the Efficacy of Cetuximab on Gastric Cancer
    SAGE Publications ; 2021
    In:  Integrative Cancer Therapies Vol. 20 ( 2021-01), p. 153473542110453-
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 20 ( 2021-01), p. 153473542110453-
    Abstract: Treatment for advanced gastric cancer is challenging. Epidermal growth factor receptor (EGFR) contributes to the proliferation and development of gastric cancer (GC), and its overexpression is associated with unfavorable prognosis in GC. Cetuximab, a monoclonal antibody targeting EGFR, failed to improve the overall survival of gastric cancer patients indicated in phase III randomized trials. Glutamine is a vital nutrient for tumor growth and its metabolism contributes to therapeutic resistance, making glutamine uptake an attractive target for cancer treatment. The aim of the present study was to investigate whether intervention of glutamine uptake could improve the effect of cetuximab on GC. The results of MTT assay showed that by glutamine deprivation or inhibition of glutamine uptake, the viability of gastric carcinoma cells was inhibited more severely than that of human immortal gastric mucosa epithelial cells (GES-1). The expression of the key glutamine transporter alanine-serine-cysteine (ASC) transporter 2 (ASCT2; SLC1A5) was significantly higher in gastric carcinoma tissues and various gastric carcinoma cell lines than in normal gastric tissues and cells, as shown by immunohistochemistry and western blotting, while silencing ASCT2 significantly inhibited the viability and proliferation of gastric carcinoma cells. Consistent with previous studies, it was shown herein by MTT and EdU assays that cetuximab had a weak inhibitory effect on the cell viability of gastric carcinoma cells. However, inhibiting glutamine uptake by blockade of ASCT2 with l-γ-glutamyl- p-nitroanilide (GPNA) significantly enhanced the inhibitory effect of cetuximab on suppressing the proliferation of gastric cancer both in vitro and in vivo. Moreover, combining cetuximab and GPNA induced cell apoptosis considerably in gastric carcinoma cells, as shown by flow cytometry, and had a higher depressing effect on gastric cancer proliferation both in vitro and in vivo, as compared to either treatment alone. The present study suggested that inhibition of glutamine uptake may be a promising strategy for improving the inhibitory efficacy of cetuximab on advanced gastric cancer.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/15347354211045349
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2101248-9
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  • 2
    Online Resource
    Online Resource
    Perfectly matched closed-loop dynamics based on IP controller for bi-axial contour following
    SAGE Publications ; 2017
    In:  Proceedings of the Institution of Mechanical Engineers, Part I: Journal of Systems and Control Engineering Vol. 231, No. 1 ( 2017-01), p. 52-62
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part I: Journal of Systems and Control Engineering, SAGE Publications, Vol. 231, No. 1 ( 2017-01), p. 52-62
    Abstract: This article aims to achieve high contour following performance for bi-axial systems. First, the effects of closed-loop dynamics on the contour following performance are analyzed and it is determined that perfectly matched closed-loop dynamics is preferable. Next, the Integral-Proportional (IP) controller is utilized to control each axis and the parameters tuning method is proposed to achieve perfect matching. The tuning method contains two main parts. One primary part is to establish the relations between the two controller parameters by setting both axes to have the same closed-loop transfer functions. The other primary part is to determine the individual IP controller parameters loop by loop according to the bandwidth index. The design process is correspondingly implemented in two steps. First, the smaller bandwidth axis controller parameters are tuned, and then the other axis is tuned according to the above relations. In applications, feedforward controllers are usually added to enhance the motion performance, whose parameters depend on the individual closed-loop dynamics and can be directly determined. The novelty of this article is that no coupling mechanism is required to perfectly match the closed-loop dynamics and the contour following performance is improved via individual controller design alone. Both the controller and the tuning method are simple and easy to implement, which are of interest to control engineers. Experiments are carried out on an X-Y motion stage, which is commanded to follow diamond and circle contours. Results show that the proposed method can match closed-loop dynamics perfectly and significantly improve the contour following performance.
    Type of Medium: Online Resource
    ISSN: 0959-6518 , 2041-3041
    URL: Article
    DOI: 10.1177/0959651816681718
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2024903-2
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  • 3
    Online Resource
    Online Resource
    High-acceleration and high-precision point-to-point motion control based on disturbance observer with improved Q-filter
    SAGE Publications ; 2015
    In:  Proceedings of the Institution of Mechanical Engineers, Part I: Journal of Systems and Control Engineering Vol. 229, No. 7 ( 2015-08), p. 587-598
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part I: Journal of Systems and Control Engineering, SAGE Publications, Vol. 229, No. 7 ( 2015-08), p. 587-598
    Abstract: Under conditions of high acceleration, high-precision and fast positioning of point-to-point motions with short strokes is restricted by the internal and external disturbances occurring in the motion process. To address this issue, a disturbance observer-based control scheme is employed here to suppress the disturbances, which combines a feedforward controller and a feedback controller. Since the low-pass filter of disturbance observer (Q-filter) determines the disturbance suppression ability after the nominal model has been identified, the Q-filter design becomes the most important consideration in practical control. In this article, an improved Q-filter is proposed to further suppress the disturbances by canceling the resonance peak of the binomial filter. High-acceleration point-to-point motions are conducted on a linear-driving stage and the experimental results demonstrate that the proposed control scheme is capable of achieving high-precision and fast positioning control. Since the improved Q-filter exhibits superior disturbance suppression ability, the positioning time with positioning error of 2 µm has been shortened from 13.1 to 11.4 ms.
    Type of Medium: Online Resource
    ISSN: 0959-6518 , 2041-3041
    URL: Article
    DOI: 10.1177/0959651815580664
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2024903-2
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  • 4
    Online Resource
    Online Resource
    Force ripple compensation of the directly-driven linear motors via iterative tuning feed-forward controller
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part I: Journal of Systems and Control Engineering Vol. 233, No. 9 ( 2019-10), p. 1239-1247
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part I: Journal of Systems and Control Engineering, SAGE Publications, Vol. 233, No. 9 ( 2019-10), p. 1239-1247
    Abstract: Linear motors are promising in improving the manufacturing equipments’ performance because of eliminating the flexible coupling component. However, the force ripple produced by the linear motors directly causes the feed fluctuation and thus degrades the motion precision. This article utilizes a feed-forward controller added to the feedback one to compensate its effect for the sake of simplicity and robustness. Considering that the force ripple is periodic to the position, a position-dependent multi-order harmonic model is built and used as the feed-forward controller. In order to obtain the controller parameters for various applications, an iterative tuning method is proposed. This method has the advantage that both the high performance for different trajectories tracking and the robustness to disturbances are guaranteed. Experiments on a linear motor illustrate that the parameters converge rapidly. The results show that the tracking performance is improved greatly and the tracking errors are reduced by 60% at least.
    Type of Medium: Online Resource
    ISSN: 0959-6518 , 2041-3041
    URL: Article
    DOI: 10.1177/0959651819827707
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024903-2
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  • 5
    Online Resource
    Online Resource
    Grab and Strip Tensile Strengths for Woven Fabrics: An Experimental Verification
    SAGE Publications ; 2005
    In:  Textile Research Journal Vol. 75, No. 11 ( 2005-11), p. 789-796
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 75, No. 11 ( 2005-11), p. 789-796
    Abstract: In the present study we have attempted to verify a theoretical model of grab versus strip strengths of fabrics [ Textile Research Journal, 2003, 73(2), 165–171] through experimental investigation. Five different fabrics were included in this study, and three related parameters were investigated including the modulus ratio of the specimen (shear versus tensile moduli), the specimen gauge length and the ungripped specimen width. The ratios of grab versus strip tensile strengths were computed from the experimental results and compared with the values predicted from the theoretical model. The predicted results are compatible with the measured values, suggesting that the theoretical model is capable of estimating the tensile strength of a grab specimen.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/0040517505057525
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2209596-2
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  • 6
    Online Resource
    Online Resource
    Elevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 11 ( 2021-11), p. 030006052110499-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 11 ( 2021-11), p. 030006052110499-
    Abstract: This study investigated the association between soluble scavenger receptor differentiation antigen 163 (sCD163) and the severity and prognosis of renal injury in lupus nephritis (LN). Methods Serum sCD163 levels in 121 Eastern Chinese patients with LN who underwent renal biopsy were determined by enzyme-linked immunosorbent assays. Clinical data were collected, and the glomerular filtration rate and disease activity score of lupus were calculated. Pathological classification was performed, and renal pathological scores were assessed by the activity index (AI) and chronic index (CI). Kaplan–Meier survival curves were drawn to evaluate prognosis. Results The pathological classification, AI and CI scores in the high sCD163 group were increased. The sCD163 levels were positively correlated with serum creatinine, blood urea nitrogen, AI scores and CI scores and negatively correlated with the estimated glomerular filtration rate. Kaplan–Meier survival analysis showed that the incidence of renal endpoint events was increased in the high sCD163 group compared with the normal sCD163 group. Conclusion The serum sCD163 level correlates with the severity of LN and is an important indicator of poor renal prognosis in patients with LN.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605211049963
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 7
    Online Resource
    Online Resource
    Cleft Palate Outcomes and Prognostic Impact of Palatal Fistula on Subsequent Velopharyngeal Function—A Retrospective Cohort Study
    SAGE Publications ; 2019
    In:  The Cleft Palate-Craniofacial Journal Vol. 56, No. 8 ( 2019-09), p. 1008-1012
    Details
    In: The Cleft Palate-Craniofacial Journal, SAGE Publications, Vol. 56, No. 8 ( 2019-09), p. 1008-1012
    Abstract: To assess outcomes from cleft palate repair and define the level of impact of palatal fistula on subsequent velopharyngeal function. Design: A retrospective cohort study. Setting: A regional specialist cleft lip and palate center within United Kingdom. Patients, Participants: Nonsyndromic infants born between 2002 and 2009 undergoing cleft palate primary surgery by a single surgeon with audited outcomes at 5 years of age. Four hundred ten infants underwent cleft palate surgery within this period and 271 infants met the inclusion criteria. Interventions: Cleft palate repair including levator palati muscle repositioning with or without lateral palatal release. Main Outcome Measures: Postoperative fistula development and velopharyngeal function at 5 years of age. Results: Lateral palatal incisions were required in 57% (156/271) of all cases. The fistula rate was 10.3% (28/271). Adequate palatal function with no significant velopharyngeal insufficiency (VPI) was achieved in 79% of patients (213/271) after primary surgery only. Palatal fistula was significantly associated with subsequent VPI (risk ratio = 3.03, 95% confidence interval: 1.95-4.69; P 〈 .001). The rate of VPI increased from 18% to 54% when healing was complicated by fistula. Bilateral cleft lip and palate (BCLP) repair complicated by fistula had the highest incidence of VPI (71%). Conclusions: Cleft palate repair with levator muscle repositioning is an effective procedure with good outcomes. The prognostic impact of palatal fistula on subsequent velopharyngeal function is defined with a highly significant 3-fold increase in VPI. Early repair of palatal fistula should be considered, particularly for large fistula and in BCLP cases.
    Type of Medium: Online Resource
    ISSN: 1055-6656 , 1545-1569
    URL: Article
    DOI: 10.1177/1055665619829388
    RVK:
    XA 36625
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2030056-6
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  • 8
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    A CFD model for the oil discharge ratio in rotary compressors
    SAGE Publications ; 2015
    In:  Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy Vol. 229, No. 2 ( 2015-03), p. 151-159
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy, SAGE Publications, Vol. 229, No. 2 ( 2015-03), p. 151-159
    Abstract: The research on oil discharge ratio (ODR) of rotary compressors used for room air conditioners is very important to improve the performance and reliability of the compressors and their systems. This paper presents a detailed computational fluid dynamics (CFD) simulation model for the refrigerant gas flow and oil droplet flow within the shell of the compressor, which is used for investigating ODR of the compressor subjected to design changes or under different operating speeds. The geometry of the rotary compressor and its oil separating burden was presented. The CFD simulation is based on the discrete phase model (DPM). The oil droplet size distribution was defined by the Rosin–Rammler diameter distribution method. The boundary conditions of the refrigerant gas and oil droplets were established. Validation of the CFD model has been made by measuring ODR of a rotary compressor used in the high efficiency air room conditioner for different design configurations and an inverter rotary compressor with R410A. The simulation ODRs of the compressor agree within 11% of the experimental-measured ODRs. The ODR of compressor could be reduced effectively by some technique.
    Type of Medium: Online Resource
    ISSN: 0957-6509 , 2041-2967
    URL: Article
    DOI: 10.1177/0957650914560599
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2024892-1
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  • 9
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    Investigation of suction pressure pulsation prediction of rotary compressor with total variation diminishing scheme and one-dimensional accumulator model
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy Vol. 237, No. 2 ( 2023-03), p. 308-319
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy, SAGE Publications, Vol. 237, No. 2 ( 2023-03), p. 308-319
    Abstract: The suction pressure pulsation plays a significant role in rotary compressor performance, so employing gas dynamic model for simulation is critical for compressor performance prediction and structure design. Comparing with the conventional Lax-wendroff two-step (LW2) scheme which has been usually utilized with good behaviors of speed and stability, this paper adopted the total variation diminishing scheme with higher convergence speed and less dispersion. And the common zero-dimensional model for the accumulator is updated to a one-dimensional model achieving more accurate pressure results at the suction pipe inlet. The simulation results of instantaneous pressure are also compared with experimental measured data under different conditions. The Pearson Correlation Coefficient of simulated pressure curves are all higher than 0.9 and the relative errors of predicted performance are almost all less than 5%, which indicates better agreement on pressure pulsation simulation and performance prediction.
    Type of Medium: Online Resource
    ISSN: 0957-6509 , 2041-2967
    URL: Article
    DOI: 10.1177/09576509221116492
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024892-1
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  • 10
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    A Review of the Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicology of Corydalis yanhusuo
    SAGE Publications ; 2020
    In:  Natural Product Communications Vol. 15, No. 9 ( 2020-09-01), p. 1934578X2095775-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 15, No. 9 ( 2020-09-01), p. 1934578X2095775-
    Abstract: Corydalis yanhusuo W. T. Wang (Papaveraceae) is a traditional Chinese herbal medicine that has long been used to treat several conditions and is widely distributed in Asian countries. This review focuses on the traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of C. yanhusuo. The literature on C. yanhusuo was reviewed using several resources, including classic books on Chinese herbal medicine and scientific databases, namely, PubMed, Springer, Web of Science, Science Direct, and China National Knowledge Infrastructure. Based on information from these databases regarding the chemical components of C. yanhusuo, we evaluated the underlying interaction network between chemical components, biological targets, and associated diseases using Cytoscape software. To date, more than 160 compounds have been isolated and identified from C. yanhusuo, including alkaloids, organic acids, volatile oils, amino acids, nucleosides, alcohols, and sugars. The crude extracts and purified compounds of this plant have analgesic, antiarrhythmic, and antipeptic ulcer properties, along with hypnotic effects. However, studies on the pharmacokinetics of C. yanhusuo extracts remain limited. C. yanhusuo has therapeutic potential in diseases such as cancer and depression, probably due to glaucine and corydaline. Our network pharmacology analysis revealed interactions between 20 compounds, 54 corresponding targets, and 4 health conditions. We found that leonticine, tetrahydroberberine, and corydalmine may regulate the expression of PTGS2, PTGS1, KCNH2, SCN5A, RXRA, CAMKK2, NCOA2, and ESR1, representing a potential treatment strategy against pain, gastric ulcers, inflammation, and cardiac arrhythmias. Additionally, this article discusses the future directions of research on C. yanhusuo.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X20957752
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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