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  • SAGE Publications  (22)
  • Wu, Jianhua  (22)
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  • SAGE Publications  (22)
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  • 11
    Online Resource
    Online Resource
    MIF associated with pulmonary hypertension susceptibility and severity in non-dialysis Chronic kidney disease patients
    SAGE Publications ; 2020
    In:  European Journal of Inflammation Vol. 18 ( 2020-01), p. 205873922096119-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 18 ( 2020-01), p. 205873922096119-
    Abstract: Pulmonary hypertension (PAH) is one of the more serious complications of Chronic kidney disease (CKD), and its exact pathogenesis has not been clarified. As an upstream proinflammatory factor, macrophage migration inhibitor (MIF) is involved in the occurrence and development of many diseases. This study aimed to detect the relationship between serum MIF and PAH in non-dialysis CKD patients. A total of 382 non-dialysis CKD patients were enrolled in this study. Bio-Plex cytokine assay was used to detect MIF. CKD patients were divided into the PAH group and non-PAH group according to echocardiographic results. Relative risk was determined by logistic regression analysis. The pulmonary artery pressure in the CKD group was higher than that in the control group ( p  〈  0.01). Pulmonary arterial pressure was higher in stage 4 to 5 CKD patients than in Stage 1 to 3 CKD patients ( p  〈  0. 01), and the incidence of PAH was also increased ( p  〈  0. 01). MIF in the CKD group were higher than in the control group ( p  〈  0.05). MIF in CKD patients with PAH were higher than those without PAH ( p  〈  0.05). Multivariate logistic regression analysis showed that MIF is correlated with PAH (OR = 10.745; 95% CI 2.288–89.447, p  〈  0.05). PAH is common in non-dialysis CKD patients, and with the deterioration of kidney disease, the incidence of PAH is gradually increased, indicating that MIF plays an important role in the development of PAH in CKD patients.
    Type of Medium: Online Resource
    ISSN: 2058-7392 , 2058-7392
    URL: Article
    DOI: 10.1177/2058739220961191
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2584683-8
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  • 12
    Online Resource
    Online Resource
    A dynamic model for pin coupling anti-rotation mechanism of automotive scroll compressor
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering Vol. 237, No. 4 ( 2023-08), p. 1460-1475
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, SAGE Publications, Vol. 237, No. 4 ( 2023-08), p. 1460-1475
    Abstract: Pin coupling anti-rotation mechanism is adopted in mechanically driven automotive scroll compressor due to its simple structure and high reliability. However, the sidewall of anti-rotation hole in pin coupling anti-rotation mechanism is easy to be worn out, deteriorating the performance of scroll compressor. To figure out the cause and take measures, a dynamic model for pin coupling anti-rotation mechanism is developed in this paper. The dynamic model takes two important factors into consideration, offsetting scroll wraps and radial compliance mechanism. Using the dynamic model, the contact force between the anti-rotation pin and anti-rotation hole can be determined, thus the wear zone can be predicted during one rotation cycle. A simulation program adopting the above dynamic model is developed to predict the performance of automotive scroll compressor. The error between simulated shaft power of compressor and experimental result is no more than 4% for all test conditions. The wear zone predicted by the simulation program agrees well with the actual scroll compressor which survived a durability test.
    Type of Medium: Online Resource
    ISSN: 0954-4089 , 2041-3009
    URL: Article
    DOI: 10.1177/09544089221116214
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024897-0
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  • 13
    Online Resource
    Online Resource
    CAD/CAM nitinol bonded retainer versus a chairside rectangular-chain bonded retainer: A multicentre randomised controlled trial
    SAGE Publications ; 2023
    In:  Journal of Orthodontics Vol. 50, No. 1 ( 2023-03), p. 55-68
    Details
    In: Journal of Orthodontics, SAGE Publications, Vol. 50, No. 1 ( 2023-03), p. 55-68
    Abstract: Bonded retainers are widely used to maintain the positions of anterior teeth after orthodontic treatment. Various types of bonded retainer exist however, there is a lack of evidence to indicate which type is superior. Aim: To compare upper and lower CAD/CAM nitinol bonded retainers (Memotain ® ) with upper and lower chairside rectangular-chain bonded retainers (Ortho-FlexTech™), in terms of stability, retainer failures and patient satisfaction. Trial design: Multi-centre, two-arm, parallel-group, randomised controlled clinical trial with 1:1 allocation. Setting: Three trial centres: University Teaching Hospital; District General Hospital; and Specialist Orthodontic Practice. All treatment was provided free as part of a state-funded healthcare system. Materials and methods: A total of 68 patients were randomly allocated to receive either upper and lower Memotain ® bonded retainers or upper and lower Ortho-FlexTech™ bonded retainers. Ten trained operators placed and reviewed the bonded retainers. Measurements were carried out on study models taken at debond and after six months. Patient satisfaction questionnaires were completed at six months following debond. Results: The trial was terminated due to the high number of failures (50%) of the upper Memotain® retainers within six months. Memotain ® retainers were three times more likely to fail (unadjusted hazard ratio = 2.82, 95% confidence interval = 1.00-7.99) than Ortho-FlexTech™ retainers at six months in the upper arch. Patients were satisfied with both types of retainer. Limitations: Early termination of the trial means that the a priori sample size was not reached, so outcomes should be interpreted with caution. Conclusion: The trial was terminated early due to the high failure rate of upper Memotain ® bonded retainers. They had a higher risk of failure in the maxillary arch when compared to upper Ortho-FlexTech™ bonded retainers after six months.
    Type of Medium: Online Resource
    ISSN: 1465-3125 , 1465-3133
    URL: Article
    DOI: 10.1177/14653125221118935
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 1466695-9
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  • 14
    Online Resource
    Online Resource
    Experimental study on P-V diagram and valve displacement of a HC290 rotary compressor
    SAGE Publications ; 2015
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 229, No. 17 ( 2015-12), p. 3113-3124
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 229, No. 17 ( 2015-12), p. 3113-3124
    Abstract: HC290 is a substitute for R22 and R410A for small heat pumps, room air conditioners, and light commercial refrigeration equipment since it has a negligible environmental impact and high efficiency. The performance, P-V diagram and valve dynamic displacement of a rotary compressor using R22 and R290 as the refrigerant, under five different operating conditions, were measured and analyzed in this paper to help understand the characteristics of internal thermodynamic process and the distribution of indicated power losses. Further, a new method for analyzing the P-V diagram of a rotary compressor was proposed. Compared with the R22 compressor, some conclusions about the discharge process starting angle, dynamic variation of pressure in the cylinder, volumetric efficiency, indicated efficiency, and loss distribution of the R290 rotary compressor under high efficiency conditions were given. The performance variation of the R290 compressor under other conditions was explained. Several measures to increase the energy efficiency of the R290 rotary compressor were proposed.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406214566220
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2024890-8
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  • 15
    Online Resource
    Online Resource
    Mechanical, Biomechanical and Psychophysical Study of Carpet Performance
    SAGE Publications ; 2007
    In:  Textile Research Journal Vol. 77, No. 3 ( 2007-03), p. 172-178
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 77, No. 3 ( 2007-03), p. 172-178
    Abstract: This study investigated carpet performance by using mechanical, biomechanical and psychophysical methods. Four different carpets were tested in this study using a force platform which also served as a hard control floor. Compliance modulus was measured to characterize the mechanical property of carpets. Six college students stood barefoot on the force platform covered by a carpet sample under both eyes-open and eyes-closed conditions. The center of pressure recorded by the force platform was used to quantify the postural sway in quiet stance. Perceived comfort was evaluated in different body areas for each flooring condition. Visual environment was found to significantly influence postural sway in quiet standing, and more compliant carpets were observed in general to be associated with faster sway velocity and smaller sway area. Also, more compliant carpets provided better perceived comfort, in particular in ankles and feet.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/0040517507079411
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2209596-2
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  • 16
    Online Resource
    Online Resource
    Dicer Suppresses Hepatocellular Carcinoma via Interleukin-8 Pathway
    SAGE Publications ; 2023
    In:  Clinical Medicine Insights: Oncology Vol. 17 ( 2023-01), p. 117955492311612-
    Details
    In: Clinical Medicine Insights: Oncology, SAGE Publications, Vol. 17 ( 2023-01), p. 117955492311612-
    Abstract: Elevated level of interleukin-8 (IL-8) promotes hepatocellular carcinoma (HCC) development and contributes to poor prognosis. Previously, we have proved that Dicer inhibits HCC progression. In this study, we evaluated the potential interaction between IL-8 and Dicer as well as their influence on HCC. Methods: Hepatocellular carcinoma cells of SMMC-7721 were divided into 2 groups for subsequent analysis: pCMV-Dicer group for Dicer-overexpressing lentivirus transfected cells (pCMV-Dicer cells) and pCMV-NC group for empty lentivirus transfected cells (pCMV-NC cells). Cell Counting kit-8 (CCK8), wound healing, and transwell were used to evaluate the inhibitory effect of Dicer overexpression on proliferation, migration, and invasion of HCC cells. The level of IL-8 was measured by flow cytometry bead-based immunoassays. Male nude BALB/c mice injected with pCMV-Dicer or pCMV-NC cell suspensions was used for transplant of HCC tumor. Results: We found that the secretion of IL-8 was reduced in the medium of pCMV-Dicer cells ( P = .027). Recombinant human IL-8 (rhIL-8) reversed the inhibitory effect of Dicer on proliferation ( P 〈 .01), migration ( P = .003), and invasion ( P = .001), whereas IL-8 inhibitor of reparixin enhanced inhibitory effect of Dicer on proliferation ( P 〈 .05), migration ( P = .008), and invasion ( P = .000). Lenvatinib downregulated the IL-8 level of HCC cells ( P = .000) as well as promote Dicer-induced inhibition for HCC cells referring to proliferation ( P 〈 .05), migration ( P = .000), and invasion ( P = .000). Animal experiments also demonstrated that Dicer cooperated with lenvatinib to inhibit the growth of HCC tumors ( P 〈 .05). Conclusions: Dicer cooperated with lenvatinib to inhibit HCC growth via downregulating IL-8, and Dicer displayed its potential capability to enhance the anti-tumor effect of lenvatinib.
    Type of Medium: Online Resource
    ISSN: 1179-5549 , 1179-5549
    URL: Article
    DOI: 10.1177/11795549231161212
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2577877-8
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  • 17
    Online Resource
    Online Resource
    The Effects of Vibration on the Gait Pattern and Vibration Perception Threshold of Children With Idiopathic Toe Walking
    SAGE Publications ; 2015
    In:  Journal of Child Neurology Vol. 30, No. 8 ( 2015-07), p. 1010-1016
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 30, No. 8 ( 2015-07), p. 1010-1016
    Abstract: The effectiveness of idiopathic toe walking treatments is not conclusive. The study investigated the use of vibration as a therapeutic/treatment method for children with idiopathic toe walking. Fifteen children with idiopathic toe walking and 15 typically developing children, aged 4 to 10 years, completed the study. The study included a barefoot gait examination and a vibration perception threshold test before and after standing on a whole body vibration machine for 60 seconds. Temporal-spatial parameters were recorded along with HR32, a calculation designed to distinguish on aspects of the toe-walking pattern. No significant gait pattern differences were found between children with idiopathic toe walking and typically developing children after one bout of vibration intervention. HR32 was found to be a means to identify the toe-walking pattern ( P 〈 .001). Hypersensitivity to vibration of children with idiopathic toe walking was not found in the current study ( P = .921).
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/0883073814550655
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2068710-2
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  • 18
    Online Resource
    Online Resource
    The Effects of Walking Surface on the Gait Pattern of Children With Idiopathic Toe Walking
    SAGE Publications ; 2016
    In:  Journal of Child Neurology Vol. 31, No. 7 ( 2016-06), p. 858-863
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 31, No. 7 ( 2016-06), p. 858-863
    Abstract: Idiopathic toe walking treatments are not conclusively effective. This study investigated the effects of walking surface on gait parameters in children with idiopathic toe walking. Fifteen children with idiopathic toe walking and 15 typically developing children aged 4 to 10 years completed the study, which included a barefoot gait exam over three 4-m walkways. Each of the walkways was covered with a different surface: vinyl tile, carpet, and pea gravel. Temporal-spatial parameters were recorded along with a measure of early heel rise (HR32). Children with idiopathic toe walking and typically developing children shared similarly changed gait patterns on each surfaces. Only HR32 was significantly different between the groups ( P 〈 .001). Children with idiopathic toe walking showed significantly less toe-walking on the gravel walkway ( P 〈 .001). Walking surface plays a significant role in altering gait patterns in both children with idiopathic toe walking and typically developing children. Walking on a gravel surface should be further explored for idiopathic toe walking.
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/0883073815624760
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2068710-2
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  • 19
    Online Resource
    Online Resource
    Study on a variable wall thickness profile of electric scroll compressor used for automobile air conditioner
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy Vol. 237, No. 2 ( 2023-03), p. 294-307
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy, SAGE Publications, Vol. 237, No. 2 ( 2023-03), p. 294-307
    Abstract: Profile design plays an important role in improving the performance and reliability of scroll compressors. To expand design ideas of variable wall thickness profile (VWTP) of electric scroll compressor used for automobile air conditioner, a method to generate and modify VWTP is developed in this paper. The VWTP is generated according to the generalized profile theory and modified with symmetrical arc modification (SAM) and symmetrical arc plus line modification (SAPLM) at the central part. To make sure that the generated VWTP can form scroll profile, the generation conditions for coefficients of swing radius are discussed in detail. For the VWTP modified with SAM and SAPLM at the central part, a new way to classify scroll chambers and analyze the evolution of scroll chambers is proposed. Geometry analyses such as conjugate points on involute curves and arc segments, volume and its derivative with respect to orbiting angle are conducted as well. The generation and geometry analysis method of VWTP is validated through a design example of VWTP for electric scroll compressor with a displacement of 34 mL. The performance of the electric scroll compressor was tested through experiment and the results show that the cooling capacity can reach 7.5 kW and the COP can reach 3.0.
    Type of Medium: Online Resource
    ISSN: 0957-6509 , 2041-2967
    URL: Article
    DOI: 10.1177/09576509221111238
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024892-1
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  • 20
    Online Resource
    Online Resource
    Research of the real-time interpolation based on piecewise power basis functions
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture Vol. 233, No. 3 ( 2019-02), p. 889-899
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, SAGE Publications, Vol. 233, No. 3 ( 2019-02), p. 889-899
    Abstract: With the outstanding geometric properties of B-spline, its recursive algorithm has been widely applied in numerical control systems to compute interpolation points and their derivatives. However, some of the B-spline basis functions in the recursive algorithm are computed repeatedly during the numerical control interpolation, which makes the interpolation efficiency greatly deteriorated. To deal with this issue, an effective approach by converting B-spline to piecewise power basis functions is proposed in this article. With the proposed power basis functions, formulas for computing interpolation point and its derivative can be established explicitly. Thus, the repeated computation due to the implicit expression can be avoided. To further improve the real-time interpolation performance, curve subdivision based on the proposed power basis functions is implemented simultaneously. Theoretical analysis shows that the computational complexity of the proposed method can be reduced by 71.1% compared with the DeBoor-Cox algorithm during the computation of interpolation points and their derivatives. Furthermore, the computational complexity of the curve subdivision can be reduced by 64.5%. Experimental results on a two-dimensional butterfly and a three-dimensional pigeon show that the proposed methods can greatly improve the computational efficiency.
    Type of Medium: Online Resource
    ISSN: 0954-4054 , 2041-2975
    URL: Article
    DOI: 10.1177/0954405418759703
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2032745-6
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