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  • Wiley  (4)
  • Wu, Hao  (4)
  • 1
    Online Resource
    Online Resource
    Nonmetastatic breast cancer patients subsequently developing second primary malignancy: A population‐based study
    Wiley ; 2021
    In:  Cancer Medicine Vol. 10, No. 23 ( 2021-12), p. 8662-8672
    Details
    In: Cancer Medicine, Wiley, Vol. 10, No. 23 ( 2021-12), p. 8662-8672
    Abstract: With life span extending, breast cancer (BC) survivors may face the possibility of developing second primary cancer (SPC) and considerably shorten survivorship. However, little is known about multiple primary cancer (MPC) patients with nonmetastatic breast cancer as a first primary malignancy (BCFPM). Methods Here, we retrospectively analyzed data on cancer survivors with BCFPM diagnosed between 2010 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. The prognostic factors for breast cancer‐specific survival (BCSS) were ascertained by the stepwise regression analysis and a competing risk model, and were integrated to the establishment of prognostic nomogram, of which the accuracy was measured by the calibration curve and the concordance index (C‐index). Results In total, 8616 patients were identified with 4.6% of 3‐year breast cancer‐ specific death (BCSD) and 8.6% of 5‐year BCSD. The most common SPC among BCFPM patients were female BC and lung cancer. Besides, the median latency time between BC and SPC was 22 months. At a ratio of 7:3, all patients were randomly categorized into a training cohort ( n  = 6032) and a validation cohort ( n  = 2584). By a proportional subdistribution hazards regression analysis, the following factors were considered to own independent prognostic abilities of BCSS: subtypes, grade, T classification, N classification, radiation, and sites of SPC. The nomogram could accurately predict 3‐year and 5‐year breast cancer‐associated survival of BCFPM patients with high internal and external validated C‐index, 0.715 (95% CI, 0.691–0.739), and 0.683 (95% CI, 0.642–0.724), respectively. Conclusions BC survivors remained a high risk of developing SPC and considerably shortened survival time. In this study, a favorable nomogram was constructed to as a prediction model for 3‐year and 5‐year BCSS of BCFPM patients, largely intending to prolong the life of these patients by assisting clinicians to make individualized follow‐up plans.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v10.23
    DOI: 10.1002/cam4.4351
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2659751-2
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  • 2
    Online Resource
    Online Resource
    Porous Titanium Scaffolds with Mechanoelectrical Conversion and Photothermal Function: A Win‐Win Strategy for Bone Reconstruction of Tumour‐Resected Defects
    Wiley ; 2023
    In:  Advanced Healthcare Materials
    Details
    In: Advanced Healthcare Materials, Wiley
    Abstract: Bone metastases severely threaten the lives of patients. Although surgical treatment combined with adjuvant chemotherapy significantly improves the survival rate of patients, tumour recurrence or metastasis after surgical resection and bone defects caused by surgical treatment remain major challenges for clinicians. Given the abovementioned clinical requirements, barium titanate‐containing iron‐coated porous titanium alloy scaffolds have been proposed to promote bone defect repair and inhibit tumour recurrence. Fortunately, in vitro and in vivo experimental research confirmed that barium titanate containing iron‐coated porous titanium alloy scaffolds promoted osteogenesis and bone reconstruction in defect repair via mechanoelectric conversion and inhibited tumour recurrence via photothermal effects. Furthermore, the underlying and intricate mechanisms of bone defect repair and tumour recurrence prevention of barium titanate‐containing iron‐coated porous titanium alloy scaffolds were explored. A win‐win strategy for mechanoelectrical conversion and photothermal functionalisation provides promising insights into bone reconstruction of tumour‐resected defects. This article is protected by copyright. All rights reserved
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Article
    DOI: 10.1002/adhm.202302901
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2645585-7
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  • 3
    Online Resource
    Online Resource
    A Single‐Step‐Grown Semiconducting vdW Heterostructure of Tungsten Oxide–Sulfide for High‐Performance Photodetection
    Wiley ; 2022
    In:  Advanced Functional Materials Vol. 32, No. 41 ( 2022-10)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 32, No. 41 ( 2022-10)
    Abstract: Ultrathin semiconducting van der Waals (vdW) heterostructures based on transition metal dichalcogenides (TMDs) play a critical role in developing next‐generation electronic and optoelectronic devices. The replacement of one component of the heterostructure by transition metal oxides (TMOs) certainly brings in numerous benefits including long‐term stability and novel functionalities. However, the single‐step chemical‐vapor deposition growth of TMOs/TMDs vdW heterostructures, as a highly desired approach for large‐scale fabrication and practical implementation, is challenging due to contradictory growth atmospheres of TMOs and TMDs. Here, the single‐step growth of an ultrathin WO 3–x /WS 2 vdW heterostructure based on the quantity‐driven discrepant interaction between S and the precursor, in which S induces sulfidation to produce WS 2 in the S‐rich phase and is changed to the reduction role to obtain sub‐stoichiometric WO 3–x in the S‐deficient phase is realized. Both WO 3–x and WS 2 exhibit semiconducting properties with a favorable type‐II band alignment. A wide response across the entire visible spectrum with a large photo‐responsivity of 4375 A W −1 , a detectivity of 5.47 × 10 11  Jones, and sub‐ms switching kinetics at 405 nm is achieved without gating bias, which is significantly improved over other reported ultrathin vdW heterostructures. This study demonstrates the possibility of single‐step‐growing TMOs/TMDs vdW heterostructures and their strong potential in high‐performance optoelectronic devices.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v32.41
    DOI: 10.1002/adfm.202202239
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 4
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    Online Resource
    Clinical application of 3D ‐printed biodegradable lumbar interbody cage (polycaprolactone/β‐tricalcium phosphate) for posterior lumbar interbody fusion
    Wiley ; 2023
    In:  Journal of Biomedical Materials Research Part B: Applied Biomaterials Vol. 111, No. 7 ( 2023-07), p. 1398-1406
    Details
    In: Journal of Biomedical Materials Research Part B: Applied Biomaterials, Wiley, Vol. 111, No. 7 ( 2023-07), p. 1398-1406
    Abstract: A novel 3D‐printed biodegradable cage composed of polycaprolactone (PCL) and beta‐tricalcium phosphate (β‐TCP) in a mass ratio of 50:50, with stable resorption patterns and mechanical strength has been developed for lumbar interbody fusion. This is a prospective cohort study to evaluate the short‐ and mid‐term safety and efficacy of this biodegradable cage in posterior lumbar interbody fusion (PLIF) surgery. This was a prospective single‐arm pilot clinical trial in 22 patients with a follow‐up time of 1, 3, 6, and 12 months, postoperatively. Clinical outcomes were assessed using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire (JOABPEQ) and Visual analogue scale (VAS) for leg pain and low back pain. Radiological examination included X‐ray, CT scan, and three‐dimensional reconstruction to evaluate surgical indications, intervertebral space height (ISH), intervertebral bone fusion and cage degradation. A total of 22 patients was included, with an average age of 53.5 years. Among 22 patients, one patient lost to follow‐up and one patient withdrew from the clinical trial because of cage retropulsion. The remaining 20 patients showed significant improvement in clinical and imaging outcomes compared to the preoperative period. The overall mean VAS for back decreased from 5.85 ± 0.99 preoperatively to 1.15 ± 0.86 at the 12‐month follow‐up ( p   〈  .001); the VAS for leg decreased from 5.75 ± 1.11 to 1.05 ± 0.76 ( p   〈  .001); the JOA score improved from 13.8 ± 2.64 to 26.45 ± 2.46 ( p   〈  .001). The mean intervertebral space height (ISH) increased from 11.01 ± 1.75 mm preoperatively to 12.67 ± 1.89 mm at the 12‐month follow‐up and the bone fusion reached 95.2% (20/21 disc segments). Partial resorption (inferior to 50% compared with the initial cage size) were found in all cages (21/21). The clinical and radiological assessments showed that the application of 3D‐printed biodegradable PCL/β‐TCP cages in PLIF yielded satisfactory results at the 12‐month follow‐up. In the future, long‐term clinical observations and controlled clinical trials are required to further validate the safety and efficacy of this novel cage.
    Type of Medium: Online Resource
    ISSN: 1552-4973 , 1552-4981
    URL: Issue
    URL: Article
    DOI: 10.1002/jbm.b.v111.7
    DOI: 10.1002/jbm.b.35244
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2130917-6
    SSG: 12
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