In:
Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 804 ( 2013-9), p. 85-88
Abstract:
Purpose:in this study, the conditions of the preparation of NDV-N-2-HACC/CMC microspheres are optimized. Methods:Using entrapment efficiency, particle size, Zeta potential as the evaluating indicators, 3 main factors to influence the preparation for microspheres were optimized by orthogonal factorization method. Result:The optimal conditions were 1.0 mg/ml HACC, 1.2 mg/ml CMC, 1:3 (v/v) NDV/HACC, and 1200 r/min and 30 min for stirring. The range of particle size was 192.1-595.2 nm, and average size was 304.3 nm. Zeta potential was +32.50 mV; encapsulation efficiency (EE) was (98.96±2.1) %.Conclusion:the conditions of the preparation of NDV-N-2-HACC/CMC microspheres are optimized.
Type of Medium:
Online Resource
ISSN:
1662-8985
DOI:
10.4028/www.scientific.net/AMR.804
DOI:
10.4028/www.scientific.net/AMR.804.85
Language:
Unknown
Publisher:
Trans Tech Publications, Ltd.
Publication Date:
2013
detail.hit.zdb_id:
2265002-7
Permalink