In:
Neonatology, S. Karger AG, Vol. 35, No. 1-2 ( 1979), p. 1-7
Kurzfassung:
The influence of prenatal and continuous postnatal protein-restricted diet on the development of rats was investigated. Virgin female rats were maintained for 35 days on isocaloric diets containing 8 or 25% casein, and then mated. The animals were supplied their respective diets during gestation and nursing. It was observed that the offspring of mothers kept on the 8% casein diet had 50% less body weight, and 10–15% less brain weight than the corresponding controls. The peak of rapid brain growth for both groups of animals occurred at age 6 days. The rate of 〈 i 〉 de novo 〈 /i 〉 biosynthesis of sterols, following the injection of (2- 〈 sup 〉 14 〈 /sup 〉 C)-mevalonic acid into the midline thalamic area and the cerebellum, was also investigated. A significant shift of the age of peaking of 〈 sup 〉 14 〈 /sup 〉 C-incorporation into sterols in the cerebellum was noted. Our results indicate that although unlimited amounts of food were supplied to the mothers on the 8% casein diet, this could not offset the detrimental effect of the protein deficiency on the offspring.
Materialart:
Online-Ressource
ISSN:
1661-7800
,
1661-7819
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
1979
ZDB Id:
2403535-X
SSG:
12
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