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  • 1
    Online Resource
    Online Resource
    Network Optimization of Functional Connectivity Within Default Mode Network Regions to Detect Cognitive Decline
    Institute of Electrical and Electronics Engineers (IEEE) ; 2017
    In:  IEEE Transactions on Neural Systems and Rehabilitation Engineering Vol. 25, No. 7 ( 2017-7), p. 1079-1089
    Details
    In: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Institute of Electrical and Electronics Engineers (IEEE), Vol. 25, No. 7 ( 2017-7), p. 1079-1089
    Type of Medium: Online Resource
    ISSN: 1534-4320 , 1558-0210
    URL: Journal
    URL: Article
    DOI: 10.1109/TNSRE.7333
    DOI: 10.1109/TNSRE.2017.2679056
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017
    detail.hit.zdb_id: 2021739-0
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    S1‐01‐01: Long‐term effects of cognitive training
    Wiley ; 2010
    In:  Alzheimer's & Dementia Vol. 6, No. 4S_Part_2 ( 2010-07)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 6, No. 4S_Part_2 ( 2010-07)
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Article
    DOI: 10.1016/j.jalz.2010.05.182
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2201940-6
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  • 3
    Online Resource
    Online Resource
    Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults
    Springer Science and Business Media LLC ; 2021
    In:  Scientific Reports Vol. 11, No. 1 ( 2021-06-28)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-06-28)
    Abstract: Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer’s Preventive Trial (MAPT) and were classified as normal cognition (NC) or mild cognitive impairment (MCI). Cognitive functions were measured as mini mental state examination (MMSE) and composite cognitive score (CCS) over a 4-year period. Plasma NfL was measured at the first or the second year of the MAPT. Mixed-effects linear models were performed to evaluate cross-sectional and longitudinal associations. In the whole population, higher plasma NfL was cross-sectionally associated with lower cognitive functions (MMSE: β =  − 0.007, 95% CI [− 0.013, − 0.001]; CCS: β =  − 0.003, 95% CI [− 0.006, − 0.001] ). In adults with MCI, but not NC, higher plasma NfL was associated with lower CCS at the cross-sectional level (β =  − 0.003, 95% CI [− 0.005, − 0.0002]). The upper quartile NfL group further demonstrated more over time decline in CCS (β =  − 0.07, 95% CI [− 0.12, − 0.01] ) under the MCI status. Plasma NfL can be a promising biomarker of progressive cognition decline in older adults with MCI.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-021-91038-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
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  • 4
    Online Resource
    Online Resource
    The Indiana Alzheimer Disease Centers Symposium on Mild Cognitive Impairment. Cognitive Training in Older Adults: Lessons from the ACTIVE Study
    Bentham Science Publishers Ltd. ; 2009
    In:  Current Alzheimer Research Vol. 6, No. 4 ( 2009-08-01), p. 375-383
    Details
    In: Current Alzheimer Research, Bentham Science Publishers Ltd., Vol. 6, No. 4 ( 2009-08-01), p. 375-383
    Type of Medium: Online Resource
    ISSN: 1567-2050
    URL: Article
    DOI: 10.2174/156720509788929345
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2009
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  • 5
    Online Resource
    Online Resource
    Physical Activity, Body Mass Index, and Blood Progranulin in Older Adults: Cross-Sectional Associations in the MAPT Study
    Oxford University Press (OUP) ; 2022
    In:  The Journals of Gerontology: Series A Vol. 77, No. 6 ( 2022-06-01), p. 1141-1149
    Details
    In: The Journals of Gerontology: Series A, Oxford University Press (OUP), Vol. 77, No. 6 ( 2022-06-01), p. 1141-1149
    Abstract: Physical activity (PA) has been shown to moderate the negative effects of obesity on pro-inflammatory cytokines but its relationship with the adipokine progranulin (PGRN) remains poorly investigated. This study aimed to examine the cross-sectional main and interactive associations of body mass index (BMI) and PA level with circulating PGRN in older adults. Five-hundred and twelve participants aged 70 years and older involved in the Multidomain Alzheimer Preventive Trial (MAPT) study who underwent plasma PGRN measurements (ng/mL) were included. Self-reported PA levels were assessed using questionnaires. People were classified into 3 BMI categories: normal weight, overweight, or obesity. Further categorization using PA tertiles was used to define highly active, moderately active, and low active individuals. Multiple linear regressions were performed in order to test the associations of BMI, PA level, and their interaction with PGRN levels. Multiple linear regressions adjusted by age, sex, diabetes mellitus status, total cholesterol, creatinine level, and MAPT group demonstrated significant interactive associations of BMI status and continuous PA such that in people without obesity, higher PA levels were associated with lower PGRN concentrations, while an opposite pattern was found in individuals with obesity. In addition, continuous BMI was positively associated with circulating PGRN in highly active individuals but not in their less active peers. This cross-sectional study demonstrated reverse patterns in older adults with obesity compared to those without obesity regarding the relationships between PA and PGRN levels. Longitudinal and experimental investigations are required to understand the mechanisms that underlie the present findings. Clinical Trials Registration Number: NCT00672685
    Type of Medium: Online Resource
    ISSN: 1079-5006 , 1758-535X
    URL: Article
    DOI: 10.1093/gerona/glac018
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2043927-1
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults
    Springer Science and Business Media LLC ; 2020
    In:  Alzheimer's Research & Therapy Vol. 12, No. 1 ( 2020-12)
    Details
    In: Alzheimer's Research & Therapy, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2020-12)
    Abstract: Cognition is closely associated with physical function. Although high brain amyloid-β (Aβ) deposition and neurofilament light chain (NfL) are associated with cognitive and gait speed decline, relationships of combined plasma Aβ and NfL profiles with cognitive and physical functions in older adults remain unknown. The research aim of this study was to investigate the prospective associations of combined plasma Aβ and NfL profiles with cognitive and physical functions in older adults. Methods Participants ( n  = 452, aged 76 ± 5 years) who had both plasma Aβ and NfL data collected from the Multidomain Alzheimer’s Preventive Trial (MAPT, May 2008 to April 2016) were included in the current study. These participants were from four MAPT groups (multidomain interventions [physical activity and nutritional counselling, and cognitive training], omega-3 supplementation, multidomain plus omega-3 supplementation and control group) and had received a 3-year intervention, followed by a 2-year observational follow-up. Cognitive function was evaluated as Mini-Mental State Examination and composite cognitive score (CCS, a mean Z -score combining four cognitive tests). Physical function was evaluated as gait speed (4-m usual-pace walk test) and chair-stand time (5-time maximal chair-stand test). Cognitive and physical function data measured at the time of and after blood Aβ and NfL tests were used for analysis. Participants with plasma Aβ 42 /Aβ 40 ratios lower than 0.107 and NfL levels greater than 93.04 pg/ml were classified as Aβ+ and NfL+. Multivariable regressions and mixed-effects linear models were used for the analysis. Results At the cross-sectional level, no significant association was found between Aβ+NfL+ and cognitive or physical function after controlling for age, sex, body mass index, education level and MAPT group. Evaluating longitudinal changes, participants with Aβ+NfL+ had greater annual declines in the CCS ( β  = − 0.11, 95%CI [− 0.17, − 0.05]) and gait speed ( β  = − 0.03, 95%CI [− 0.05, − 0.005]). After adjusting for APOE ɛ4 genotype, Aβ+NfL+ was associated with a greater decline only in the CCS ( β  = − 0.09, 95%CI [− 0.15, − 0.02]). Conclusions Combined low plasma Aβ 42 /Aβ 40 ratio and high plasma NfL level was associated with greater declines in cognition and gait speed over time, providing further evidence of the links between cognitive and physical function. Trial registration www.clinicaltrials.gov [ NCT00672685 ].
    Type of Medium: Online Resource
    ISSN: 1758-9193
    URL: Article
    DOI: 10.1186/s13195-020-00697-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2506521-X
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  • 7
    Online Resource
    Online Resource
    An Historical Framework for Cohort Differences in Intelligence
    Informa UK Limited ; 2005
    In:  Research in Human Development Vol. 2, No. 1 ( 2005-3-1), p. 43-67
    Details
    In: Research in Human Development, Informa UK Limited, Vol. 2, No. 1 ( 2005-3-1), p. 43-67
    Type of Medium: Online Resource
    ISSN: 1542-7609
    URL: Article
    DOI: 10.1207/s15427617rhd0201&2_3
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2005
    detail.hit.zdb_id: 2139478-7
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  • 8
    Online Resource
    Online Resource
    LONGITUDINAL ASSOCIATIONS OF DEPRESSIVE SYMPTOM AND SUBJECTIVE MEMORY FACTORS WITH OBJECTIVE MEMORY PERFORMANCE
    Oxford University Press (OUP) ; 2019
    In:  Innovation in Aging Vol. 3, No. Supplement_1 ( 2019-11-08), p. S648-S648
    Details
    In: Innovation in Aging, Oxford University Press (OUP), Vol. 3, No. Supplement_1 ( 2019-11-08), p. S648-S648
    Abstract: Prior research demonstrated a history of depressive symptoms predicted oncoming memory deficits, and that self-evaluation of memory was associated with forthcoming memory difficulties. However, prior work lacks consistent consideration of multifaceted depressive symptoms in regards to longitudinal associations with objective memory (OM). Structural models were examined to determine how latent factors of depressive symptoms (via the CES-D) and SM factors predicted memory deficits at later time points when taking into account baseline OM performance [n=270; RMSEA=.034; CFI=.974; TLI=.965] in the Seattle Longitudinal Study (mean Age=70.33; SD=7.29; mean Education=15.30; SD=2.72; 61.9% female). The somatic complaints CES-D factor showed a significant longitudinal association with OM performance after seven years (β = -.25, p & lt; .05), while none of CES-D factors showed cross-sectional associations with the baseline OM. The general frequency of forgetting SM factor was positively associated with OM performance at baseline (β = .26, p & lt; .001), suggesting that those performing better at recalling words reported fewer memory problems. None of SM factors showed longitudinal associations with OM measured seven years later, indicating that self-evaluation of memory had no impact on future memory deficits. Overall findings suggested that a key CES-D factor, somatic complaints, was detected and that people endorsing more somatic issues experienced greater memory decline over a seven year period. Thus, extending prior work, the current study suggests that although both subjective memory and depressive symptom factors showed concurrent associations, only a specific factor of depressive symptoms, somatic complaints, was influential in regards to predicting later memory performance
    Type of Medium: Online Resource
    ISSN: 2399-5300
    URL: Article
    DOI: 10.1093/geroni/igz038.2406
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2905697-4
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  • 9
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    Online Resource
    Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults
    Springer Science and Business Media LLC ; 2023
    In:  GeroScience
    Details
    In: GeroScience, Springer Science and Business Media LLC
    Abstract: The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA and proteomic risk indicators for dementia. Here we report that plasma adropin concentrations predict risk for cognitive decline in the Multidomain Alzheimer Preventive Trial (ClinicalTrials.gov Identifier, NCT00672685; mean age 75.8y, SD = 4.5 years, 60.2% female, n  = 452). Cognitive ability was evaluated using a composite cognitive score (CCS) that assessed four domains: memory, language, executive function, and orientation. Relationships between plasma adropin concentrations and changes in CCS (∆CCS) were examined using Cox Proportional Hazards Regression, or by grouping into tertiles ranked low to high by adropin values and controlling for age, time between baseline and final visits, baseline CCS, and other risk factors (e.g., education, medication, APOE4 status). Risk of cognitive decline (defined as a ∆CCS of − 0.3 or more) decreased with increasing plasma adropin concentrations (hazard ratio = 0.873, 95% CI 0.780–0.977, P  = 0.018). Between adropin tertiles, ∆CCS was significantly different ( P  = 0.01; estimated marginal mean ± SE for the 1st to 3rd tertile, − 0.317 ± 0.064; − 0.275 ± 0.063; − 0.042 ± 0.071; n  = 133,146, and 130, respectively; P   〈  0.05 for 1st vs. 2nd and 3rd adropin tertiles). Normalized plasma Aß 42/40 ratio and plasma neurofilament light chain, indicators of neurodegeneration, were significantly different between adropin tertile. These differences were consistent with reduced risk of cognitive decline with higher plasma adropin levels. Overall, these results suggest cognitive decline is reduced in community-dwelling older adults with higher circulating adropin levels. Further studies are needed to determine the underlying causes of the relationship and whether increasing adropin levels can delay cognitive decline.
    Type of Medium: Online Resource
    ISSN: 2509-2723
    URL: Article
    DOI: 10.1007/s11357-023-00824-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2886418-9
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  • 10
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    Online Resource
    0083 Longitudinal sleep instability is associated with increased MRI-visible perivascular space burden
    Oxford University Press (OUP) ; 2023
    In:  SLEEP Vol. 46, No. Supplement_1 ( 2023-05-29), p. A38-A38
    Details
    In: SLEEP, Oxford University Press (OUP), Vol. 46, No. Supplement_1 ( 2023-05-29), p. A38-A38
    Abstract: Emerging data from our group found longitudinal sleep variability within the Seattle Longitudinal Study was significantly associated with cognitive impairment and predicted cognitive impairment 10-years downstream. While this data supports a link between sleep instability, aging, and cognitive decline, the mechanism linking these processes is unknown. MRI-visible perivascular space (PVS) burden is a putative marker of glymphatic dysfunction, and previous studies suggest that sleep disruption is associated with PVS burden. Methods This a secondary analysis of subjects who a) participated in the Seattle Longitudinal Study and b) had T1-weighted 3 T MRI and FLAIR scans available for PVS analysis (n=250). We evaluated the variability (standard deviation) in each participant’s longitudinal self-reported sleep duration. White matter MRI-visible PVS were evaluated with a semi-automated segmentation algorithm, accounting PVS total burden (number/cm3), volume (mm3/cm3), as well as average PVS width, length, and median volume across participants, blinded by group. Participants were stratified into low or high-sleep variability groups. Results Preliminary analysis (n=37) demonstrated a significant association between high sleep variability and increased whole-brain PVS burden (p=0.04), with low sleep variability participants exhibiting an average of 7 PVS and high sleep variability participants an average of 11.33. Follow-up analysis evaluated PVS features within the wider cohort. Conclusion These findings suggest that variability in longitudinal sleep duration may exert a previously unappreciated influence on pathological processes, potentially including glymphatic dysfunction. Future studies within this cohort will seek to evaluate longitudinal changes in PVS burden across longitudinally-collected MRIs. Additional studies should be performed evaluating these findings on an independent cohort to assess whether sleep variability of different time scales (weeks, years, decades) exerts similar effects on these outcomes. Support (if any)  
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsad077.0083
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2056761-3
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