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  • American Association for the Advancement of Science (AAAS)  (2)
  • Wilkinson, Adam C.  (2)
Material
Publisher
  • American Association for the Advancement of Science (AAAS)  (2)
Person/Organisation
Language
Years
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation
    American Association for the Advancement of Science (AAAS) ; 2016
    In:  Science Vol. 354, No. 6316 ( 2016-12-02), p. 1152-1155
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 354, No. 6316 ( 2016-12-02), p. 1152-1155
    Abstract: A specialized bone marrow microenvironment (niche) regulates hematopoietic stem cell (HSC) self-renewal and commitment. For successful donor-HSC engraftment, the niche must be emptied via myeloablative irradiation or chemotherapy. However, myeloablation can cause severe complications and even mortality. Here we report that the essential amino acid valine is indispensable for the proliferation and maintenance of HSCs. Both mouse and human HSCs failed to proliferate when cultured in valine-depleted conditions. In mice fed a valine-restricted diet, HSC frequency fell dramatically within 1 week. Furthermore, dietary valine restriction emptied the mouse bone marrow niche and afforded donor-HSC engraftment without chemoirradiative myeloablation. These findings indicate a critical role for valine in HSC maintenance and suggest that dietary valine restriction may reduce iatrogenic complications in HSC transplantation.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.aag3145
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2016
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Changing concepts in hematopoietic stem cells
    American Association for the Advancement of Science (AAAS) ; 2018
    In:  Science Vol. 362, No. 6417 ( 2018-11-23), p. 895-896
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 362, No. 6417 ( 2018-11-23), p. 895-896
    Abstract: Hematopoietic stem cells (HSCs) can produce all cell lineages within the adult blood system, and they have provided a flagship model in which to study stem cell biology. Concepts developed from studying HSCs have influenced how we consider other stem cell systems. HSCs are also one of the few stem cell types with a long history of clinical application, in the form of bone marrow transplantation. Recent technical advances have brought about a major revision in our understanding of the HSC compartment. These necessitate new models and nomenclature to describe HSC heterogeneity, self-renewal, and differentiation potential, as well as having broader implications for how we consider stemness.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.aat7873
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2018
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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