In:
EMBO reports, EMBO, Vol. 14, No. 12 ( 2013-12), p. 1120-1126
Abstract:
This study shows that both ZNRF3‐ and LGR4‐binding motifs of R‐spondin are required for its Wnt‐promoting activity. These results support a dual receptor model of R‐spondin signalling, where LGR4 serves as the engagement receptor while ZNRF3 functions as the effector receptor.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.1038/embor.2013.167
Language:
English
Publisher:
EMBO
Publication Date:
2013
detail.hit.zdb_id:
2025376-X
SSG:
12
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