In:
Natural Product Communications, SAGE Publications, Vol. 8, No. 5 ( 2013-05), p. 1934578X1300800-
Abstract:
The leaf essential oil of Tarchonanthuscamphoratus(As teraceae) was obtained by hydrodistillation and analyzed by GC-MS. Fifty-six components were characterized, representing 94.2% of the total oil with oxygenated monoterpenes (48.3%) and oxygenated sesquiterpenes (32.7%) as the major groups. The principal constituents were identified as endo-fenchol (21.2%), trans-pinene hydrate (8.8%), caryophyllene oxide (7.5%), α-terpineol (6.4%), τ-cadinol (6.4%), and α-cadinol (5.2%). The essential oil was evaluated for its antimicrobial activity using a disc diffusion assay resulting in the moderate inhibition of a number of common human pathogenic bacteria, including methicillin-resistant Staphylococcus aureus(MRSA) and the yeast Candida albicans. The inhibition zones varied from 10 to 14mm/disc. Furthermore, the antioxidant capacity of the essential oil was examined using an in vitroradical scavenging activity test. The T. camphoratus essential oil scavenged 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), resulting in an IC 50 value of 5.6 mg/mL. At concentrations of 100 and 50μg/mL, the oil showed cytotoxic activity, with growth inhibition of 59.1% (±4.2), and 16.2% (±8.7) against HT29 tumor cells (human colonic adenocarcinoma cells), respectively(IC 50 = 84.7 ± 7.5 μg/mL).
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X1300800534
Language:
English
Publisher:
SAGE Publications
Publication Date:
2013
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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