In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 50, No. 8 ( 2006-08), p. 2860-2862
Abstract:
The distribution and resistance levels of 189 in vitro-selected rifampin-resistant Mycobacterium tuberculosis mutants of Beijing and other genotypes were determined. Apart from a higher amount of codon 522 point mutations and large deletions, a spread of mutations similar to that reported for clinical isolates was seen. Most mutations were correlated with high-level resistance; a lower level, or a MIC of 〈 16 mg/liter, was associated with codon 522 mutations. Multiple mutations were detected in two Beijing mutants.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.00303-06
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2006
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3
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