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  • Hindawi Limited  (8)
  • Wang, Zhihua  (8)
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  • Hindawi Limited  (8)
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  • 1
    Online Resource
    Online Resource
    The Antioxidant Alpha-Lipoic Acid Inhibits Proliferation and Invasion of Human Gastric Cancer Cells via Suppression of STAT3-Mediated MUC4 Gene Expression
    Hindawi Limited ; 2019
    In:  Oxidative Medicine and Cellular Longevity Vol. 2019 ( 2019-12-13), p. 1-10
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2019 ( 2019-12-13), p. 1-10
    Abstract: Background . Metastasis and invasion are the main causes of mortality in gastric cancer. To improve the treatment of gastric cancer, the development of effective and innovative antitumor agents toward invasion and proliferation is needed. Alpha-lipoic acid (ALA), a naturally occurring thiol antioxidant, showed antiproliferative and cytotoxic effects on several cancers. So it is feasible to explore whether ALA can be used to inhibit proliferation and invasion in human gastric cancer. Methods . The expression of MUC4 in human gastric cancer tissues was assayed by immunohistochemistry. Then, we performed in vitro cell proliferation and invasion analysis to explore the antitumor effect of ALA using AGS, BGC-823, and MKN-28 cells. To further explore the mechanism of ALA-mediated downregulation of MUC4, we cotransfected human gastric cancer cells with STAT3 siRNA and STAT3 overexpression construct. ChIP assays were carried out to find the relationship between MUC4 and STAT3. Results . We found that the MUC4 gene was strongly expressed in human gastric cancer tissues. Meanwhile, ALA reduced proliferation and invasion of human gastric cancer cells by suppressing MUC4 expression. We also found that STAT3 was involved in the inhibition of MUC4 by ALA. Mechanistically, ALA suppressed MUC4 expression by inhibiting STAT3 binding to the MUC4 promoter region. Conclusion . ALA inhibits both proliferation and invasion of gastric cancer cells by suppression of STAT3-mediated MUC4 gene expression.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2019/3643715
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2455981-7
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  • 2
    Online Resource
    Online Resource
    MnTE-2-PyP Attenuates TGF- β -Induced Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Inhibiting the Smad2/3 Signaling Pathway
    Hindawi Limited ; 2019
    In:  Oxidative Medicine and Cellular Longevity Vol. 2019 ( 2019-02-25), p. 1-11
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2019 ( 2019-02-25), p. 1-11
    Abstract: Background . As a key step in enhancing cancer cell invasion and metastasis, epithelial-mesenchymal transition (EMT) plays an important role in colorectal cancer progression. EMT is triggered by a variety of signaling pathways, among which the transforming growth factor β (TGF- β ) signaling pathway has been implicated as a primary inducer. Accumulating evidence demonstrates that MnTE-2-PyP (chemical name: manganese(III) meso -tetrakis-(N-ethylpyridinium-2-yl), a superoxide dismutase (SOD) mimetic, inhibits TGF- β signaling; however, its ability to inhibit TGF- β -induced EMT in colorectal cancer has not yet been explored. Methods . To verify our hypothesis that MnTE-2-PyP attenuates TGF- β -induced EMT, human colorectal cancer cells were treated with TGF- β in the presence or absence of MnTE-2-PyP. Cells were analyzed by several techniques including western blotting, real-time quantitative PCR, transwell assay, and wound healing assay. Results . MnTE-2-PyP reverses cell phenotypes induced by TGF- β in colon cancer cells. MnTE-2-PyP treatment significantly reduced the expression of mesenchymal markers but maintained epithelial marker expression. Mechanistically, MnTE-2-PyP suppressed the phosphorylated Smad2/3 protein levels induced by TGF- β in SW480 cells, but MnTE-2-PyP failed to suppress TGF- β -induced Slug and Snail expression in colorectal cells. Furthermore, MnTE-2-PyP effectively suppressed TGF- β -mediated cell migration and invasion and the expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) in colorectal cells. Conclusion . Taken together, we provide an in-depth mechanism by which MnTE-2-PyP inhibits colorectal cancer progression, supporting an important role for MnTE-2-PyP as an effective and innovative antitumor agent to enhance treatment outcomes in colorectal cancer.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2019/8639791
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2455981-7
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  • 3
    Online Resource
    Online Resource
    Identification of Calcium Channel-Related Gene P2RX2 for Prognosis and Immune Infiltration in Prostate Cancer
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-9-30), p. 1-23
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-9-30), p. 1-23
    Abstract: Prostate cancer is one of the most common malignancies in men. Calcium signaling is implicated in the progression of prostate cancer and plays a critical role in immune cell function. However, whether specific calcium channel-related genes play a crucial role in the immune cell infiltration levels of prostate cancer requires further research. In this study, we performed an integrated analysis of transcriptional, clinical, and somatic mutation data from The Cancer Genome Atlas database and identified the hub calcium channel-related gene P2RX2 to be associated with the prognosis and immune infiltration of prostate cancer. P2RX2 expression was positively correlated with immune cell infiltration levels and the expression of immune checkpoint genes, and downregulation of P2RX2 led to poor survival in patients with prostate cancer. Furthermore, we validated the molecular and clinical characteristics of P2RX2 by using multiple databases and conducting in-vitro experiments. Additionally, drug sensitivity analysis revealed that patients with low P2RX2 expression were sensitive to docetaxel and Bicalutamide. In conclusion, we revealed an association between calcium channel-related genes and prostate cancer, and identified P2RX2 as a biomarker for early diagnosis, prognosis prediction, and aiding treatment decisions for patients with prostate cancer.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/8058160
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 4
    Online Resource
    Online Resource
    A Study on Ceramsite Production Using Dredging Sea Mud and Its Biofilm Formation Capacity Evaluation
    Hindawi Limited ; 2018
    In:  Advances in Civil Engineering Vol. 2018 ( 2018-12-06), p. 1-9
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2018 ( 2018-12-06), p. 1-9
    Abstract: Dredging sea mud produced during the coastal infrastructure construction has been gradually becoming an environmental problem in China. Making ceramsite is an attractive way to convert the waste sea mud to resources used for many industrial sectors. However, the imapct of preheating and sintering conditions on the ceramsite properties and the biofilm formation capacity of the ceramsite are still poorly understood. This study aims to fill these knowledge gaps. Results suggested the optimal conditions for the preheating temperature was 350 ° C, the preheating time was 15 min, the sintering temperature was 1040 ° C, and the sintering time was 9 min. The dredging sea mud-derived ceramsite showed better biofilm formation capacity with high COD and NH 4 + -N removal performance compared with the commercial ceramsites. The content of the chloride ion in the ceramist granules is close to zero, and the low cost of this material, implying this dredging sea mud-derived ceramsite, could be an engineering favorable material for using it as a biocarrier in the real application.
    Type of Medium: Online Resource
    ISSN: 1687-8086 , 1687-8094
    URL: Article
    DOI: 10.1155/2018/2401984
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2449760-5
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  • 5
    Online Resource
    Online Resource
    Temperature Effects on Tensile and Compressive Mechanical Behaviors of C-S-H Structure via Atomic Simulation
    Hindawi Limited ; 2017
    In:  Journal of Nanomaterials Vol. 2017 ( 2017), p. 1-6
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2017 ( 2017), p. 1-6
    Abstract: An atomic scale model of amorphous calcium silicate hydrate (C-S-H) with Ca/Si ratio of 1.67 is constructed. Effects of temperature on mechanical properties of C-S-H structure under tensile and compressive loading in the layered direction are investigated via molecular dynamics simulations. Results from present simulations show that (1) the tensile strength and Young’s modulus of C-S-H structure significantly decrease with the increase of the temperature; (2) the water layer plays an important role in the mechanical properties of C-S-H structure; (3) the compressive strength is stronger than tensile strength, which corresponds with the characteristic of cement paste.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2017/8476258
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2229480-6
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  • 6
    Online Resource
    Online Resource
    Dynamic Large Deflection Response of RC Beams under Low-Speed Impact Loading
    Hindawi Limited ; 2020
    In:  Shock and Vibration Vol. 2020 ( 2020-10-21), p. 1-15
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2020 ( 2020-10-21), p. 1-15
    Abstract: The dynamic large deflection response of RC beams under low-speed impact loading at their midspan is investigated in this paper. Two simple methods such as extended Hamilton’s principle and equivalent static hypothesis are used to establish the theoretical models for both simply supported and fully clamped RC beams; analytical formulas for the maximum midspan deflection-input impact energy are obtained. The “equal area” method based on the deflection history of beams is only used during these derivations to determine the plastic bending moment and the stress distribution of the structure. Then, finite element simulations are carried out to verify the validity of the proposed predictions. It is shown that the maximum deflections for both simply supported and fully clamped beams are almost proportional with respect to the input impact energy, which agrees well with both simulations and other experimental results. Also, the boundary condition has more effect on the deflection response of the RC beams which is relatively longer.
    Type of Medium: Online Resource
    ISSN: 1875-9203 , 1070-9622
    URL: Article
    DOI: 10.1155/2020/8812890
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2070162-7
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  • 7
    Online Resource
    Online Resource
    The Influence of Pelvic Ramus Fracture on the Stability of Fixed Pelvic Complex Fracture
    Hindawi Limited ; 2015
    In:  Computational and Mathematical Methods in Medicine Vol. 2015 ( 2015), p. 1-11
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-11
    Abstract: This study aims to evaluate the biomechanical mechanism of pelvic ring injury for the stability of pelvis using the finite element (FE) method. Complex pelvic fracture (i.e., anterior column with posterior hemitransverse lesion) combined with pelvic ramus fracture was used to evaluate the biomechanics stability of the pelvis. Three FE fracture models (i.e., Dynamic Anterior Plate-Screw System for Quadrilateral Area (DAPSQ) for complex pelvic fracture with intact pubic ramus, DAPSQ for complex pelvic fracture with pubic ramus fracture, and DAPSQ for complex pelvic fracture with fixed pubic ramus fracture) were established to explore the biomechanics stability of the pelvis. The pubic ramus fracture leads to an unsymmetrical situation and an unstable situation of the pelvis. The fixed pubic ramus fracture did well in reducing the stress levels of the pelvic bone and fixation system, as well as displacement difference in the pubic symphysis, and it could change the unstable situation back to a certain extent. The pelvic ring integrity was the prerequisite of the pelvic stability and should be in a stable condition when the complex fracture is treated.
    Type of Medium: Online Resource
    ISSN: 1748-670X , 1748-6718
    URL: Article
    DOI: 10.1155/2015/790575
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2256917-0
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  • 8
    Online Resource
    Online Resource
    Hippocampal Mitochondrial Abnormalities Induced the Dendritic Complexity Reduction and Cognitive Decline in a Rat Model of Spinal Cord Injury
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-5-4), p. 1-18
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-5-4), p. 1-18
    Abstract: Spinal cord injury (SCI) is a progressive neurodegenerative disease in addition to a traumatic event. Cognitive dysfunction following SCI has been widely reported in patients and animal models. However, the neuroanatomical changes affecting cognitive function after SCI, as well as the mechanisms behind these changes, have so far remained elusive. Herein, we found that SCI accelerates oxidative stress damage of hippocampal neuronal mitochondria. Then, for the first time, we presented a three-dimensional morphological atlas of rat hippocampal neurons generated using a fluorescence Micro-Optical Sectioning Tomography system, a method that accurately identifies the spatial localization of neurons and trace neurites. We showed that the number of dendritic branches and dendritic length was decreased in late stage of SCI. Western blot and transmission electron microscopy analyses also showed a decrease in synaptic communication. In addition, a battery of behavioral tests in these animals revealed hippocampal based cognitive dysfunction, which could be attributed to changes in the dendritic complexity of hippocampal neurons. Taken together, these results suggested that mitochondrial abnormalities in hippocampal neurons induced the dendritic complexity reduction and cognitive decline following SCI. Our study highlights the neuroanatomical basis and importance of mitochondria in brain degeneration following SCI, which might contribute to propose new therapeutic strategies.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/9253916
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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