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  • 1
    Online Resource
    Online Resource
    Analysis of the Chinese Airline Network as multi-layer networks
    Elsevier BV ; 2016
    In:  Transportation Research Part E: Logistics and Transportation Review Vol. 89 ( 2016-05), p. 108-116
    Details
    In: Transportation Research Part E: Logistics and Transportation Review, Elsevier BV, Vol. 89 ( 2016-05), p. 108-116
    Type of Medium: Online Resource
    ISSN: 1366-5545
    URL: Article
    DOI: 10.1016/j.tre.2016.03.009
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 2013782-5
    SSG: 3,2
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  • 2
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    Effects of the Bone/Bone Marrow Microenvironments on Prostate Cancer Cells and CD59 Expression
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-04-06), p. 1-13
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-04-06), p. 1-13
    Abstract: Objective . To evaluate the effects of human bone marrow mesenchymal stem cells (hBMSCs) and osteoblasts (hFOB1.19) on PC3 prostate cancer cells. Methods . To simulate the in vivo interaction between the bone/bone marrow microenvironments and prostate cancer cells, we established cocultures of PC3 cells with hBMSC or hFOB1.19 cells and evaluated their effects on the proliferation, cell cycle distribution, cell migration, and invasion of PC3 cells. Quantitative reverse transcription polymerase chain reaction was used to detect CD59 mRNA expression in PC3 cells. The expression of receptor activator of nuclear factor- (NF-) κ B (RANK), RANK ligand (RANKL), osteoprotegerin (OPG), CD59, NF- κ B (p50 subunit), and cyclin D1 in PC3 cells was analyzed by immunofluorescence and western blotting. Results . hBMSCs and hFOB1.19 cells enhanced the proliferation, migration, and invasion of PC3 cells; increased the proportion of PC3 cells in the S and G 2 /M phases of the cell cycle; and upregulated RANK, RANKL, OPG, CD59, cyclin D1, and NF- κ B (p50 subunit) expression by PC3 cells. The RANKL inhibitor, scutellarin, inhibited these effects in PC3-hFOB1.19 cocultures. Conclusion . hBMSCs and hFOB1.19 cells modulate the phenotype of PC3 prostate cancer cells and the expression of CD59 by activating the RANK/RANKL/OPG signaling pathway.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2020/2753414
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2698540-8
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  • 3
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    Prediction of postoperative infection in elderly using deep learning-based analysis: an observational cohort study
    Springer Science and Business Media LLC ; 2023
    In:  Aging Clinical and Experimental Research Vol. 35, No. 3 ( 2023-01-04), p. 639-647
    Details
    In: Aging Clinical and Experimental Research, Springer Science and Business Media LLC, Vol. 35, No. 3 ( 2023-01-04), p. 639-647
    Abstract: Elderly patients are susceptible to postoperative infections with increased mortality. Analyzing with a deep learning model, the perioperative factors that could predict and/or contribute to postoperative infections may improve the outcome in elderly. This was an observational cohort study with 2014 elderly patients who had elective surgery from 28 hospitals in China from April to June 2014. We aimed to develop and validate deep learning-based predictive models for postoperative infections in the elderly. 1510 patients were randomly assigned to be training dataset for establishing deep learning-based models, and 504 patients were used to validate the effectiveness of these models. The conventional model predicted postoperative infections was 0.728 (95% CI 0.688–0.768) with the sensitivity of 66.2% (95% CI 58.2–73.6) and specificity of 66.8% (95% CI 64.6–68.9). The deep learning model including risk factors relevant to baseline clinical characteristics predicted postoperative infections was 0.641 (95% CI 0.545–0.737), and sensitivity and specificity were 34.2% (95% CI 19.6–51.4) and 88.8% (95% CI 85.6–91.6), respectively. Including risk factors relevant to baseline variables and surgery, the deep learning model predicted postoperative infections was 0.763 (95% CI 0.681–0.844) with the sensitivity of 63.2% (95% CI 46–78.2) and specificity of 80.5% (95% CI 76.6–84). Our feasibility study indicated that a deep learning model including risk factors for the prediction of postoperative infections can be achieved in elderly. Further study is needed to assess whether this model can be used to guide clinical practice to improve surgical outcomes in elderly.
    Type of Medium: Online Resource
    ISSN: 1720-8319
    URL: Article
    DOI: 10.1007/s40520-022-02325-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2119282-0
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  • 4
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    Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
    Oxford University Press (OUP) ; 2019
    In:  British Journal of Surgery Vol. 106, No. 2 ( 2019-01-08), p. e73-e80
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 106, No. 2 ( 2019-01-08), p. e73-e80
    Abstract: The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs). Methods This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs. Results A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59). Conclusion Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally.
    Type of Medium: Online Resource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1002/bjs.11025
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2006309-X
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  • 5
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    The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis
    Elsevier BV ; 2018
    In:  British Journal of Anaesthesia Vol. 120, No. 1 ( 2018-01), p. 146-155
    Details
    In: British Journal of Anaesthesia, Elsevier BV, Vol. 120, No. 1 ( 2018-01), p. 146-155
    Type of Medium: Online Resource
    ISSN: 0007-0912
    URL: Article
    DOI: 10.1016/j.bja.2017.08.002
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2011968-9
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  • 6
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    Proximal Tubule Toll-Like Receptor 4 Expression Linked to Inflammation and Apoptosis following Hypoxia/Reoxygenation Injury
    S. Karger AG ; 2014
    In:  American Journal of Nephrology Vol. 39, No. 4 ( 2014), p. 337-347
    Details
    In: American Journal of Nephrology, S. Karger AG, Vol. 39, No. 4 ( 2014), p. 337-347
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Toll-like receptor 4 (TLR4) plays a key role in mediating kidney damage during ischemia/reperfusion (I/R) injury, and its expression is enhanced following renal I/R injury. Our study focused on TLR4 silencing-mediated downstream antiapoptotic pathways during hypoxia/reoxygenation (H/R) and investigated whether TLR4 overexpression exacerbates the renal damage induced by I/R injury. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Proximal tubule epithelial cells (PTECs) were isolated and H/R injury mediated by ATP depletion, and replenishment was performed to mimic in vivo I/R injury. PTECs were transfected with either TLR4 siRNA or TLR4-overexpressing vectors to determine the contribution of TLR4 to H/R injury-induced apoptosis and inflammatory response. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 H/R injury significantly enhanced PTEC apoptosis (p 〈 0.01) and the production of tumor necrosis factor (TNF)-α and interleukin (IL)-8; however, TLR4 silencing significantly reversed these effects (p 〈 0.05). Moreover, compared to PTECs or PTECs-siCon exposed to H/R injury, overexpression of TLR4 further upregulated TNF-α and IL-8 (p 〈 0.05), but did not enhance apoptosis. The expression of cytochrome C and caspases 3, 8, and 9 was decreased in the siTLR4 group compared to controls after H/R injury, whereas TLR4 silencing did not alter CHOP expression. TLR4 overexpression failed to promote the expression of cytochrome C and caspases 3, 8, and 9, and reduced the expression of CHOP and GPR78. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Knockdown of TLR4 could protect PTECs from H/R injury via inhibiting mitochondrial and death receptor pathways. TLR4 overexpression did not increase PTEC apoptosis induced by H/R injury due in part to the downregulation of CHOP.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000360549
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1468523-1
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  • 7
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    Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction
    Springer Science and Business Media LLC ; 2022
    In:  Signal Transduction and Targeted Therapy Vol. 7, No. 1 ( 2022-01-20)
    Details
    In: Signal Transduction and Targeted Therapy, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2022-01-20)
    Abstract: Interleukin-37b (hereafter called IL-37) was identified as fundamental inhibitor of natural and acquired immunity. The molecular mechanism and function of IL-37 in colorectal cancer (CRC) has been elusive. Here, we found that IL-37 transgenic (IL-37tg) mice were highly susceptible to colitis-associated colorectal cancer (CAC) and suffered from dramatically increased tumor burdens in colon. Nevertheless, IL-37 is dispensable for intestinal mutagenesis, and CRC cell proliferation, apoptosis, and migration. Notably, IL-37 dampened protective cytotoxic T cell-mediated immunity in CAC and B16-OVA models. CD8 + T cell dysfunction is defined by reduced retention and activation as well as failure to proliferate and produce cytotoxic cytokines in IL-37tg mice, enabling tumor evasion of immune surveillance. The dysfunction led by IL-37 antagonizes IL-18–induced proliferation and effector function of CD8 + T cells, which was dependent on SIGIRR (single immunoglobulin interleukin-1 receptor-related protein). Finally, we observed that IL-37 levels were significantly increased in CRC patients, and positively correlated with serum CRC biomarker CEA levels, but negatively correlated with the CD8 + T cell infiltration in CRC patients. Our findings highlight the role of IL-37 in harnessing antitumor immunity by inactivation of cytotoxic T cells and establish a new defined inhibitory factor IL-37/SIGIRR in cancer-immunity cycle as therapeutic targets in CRC.
    Type of Medium: Online Resource
    ISSN: 2059-3635
    URL: Article
    DOI: 10.1038/s41392-021-00820-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2886872-9
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  • 8
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    Migration of pinewood nematode promotes the colonization of Esteya vermicola in pine tree
    Wiley ; 2021
    In:  Forest Pathology Vol. 51, No. 2 ( 2021-04)
    Details
    In: Forest Pathology, Wiley, Vol. 51, No. 2 ( 2021-04)
    Abstract: Esteya vermicola is a potential biological agent of the pinewood nematode (PWN), Bursaphelenchus xylophilus , due to its high infectivity. However, knowledge of E. vermicola colonization in the host pine tree is less known. To reveal the distribution pattern of E. vermicola inside the pine tree and the interactions between fungus and PWN, biocontrol tests were conducted on 10 years old Pinus densiflora . A green fluorescence protein (GFP)‐tagged E. vermicola was used to observe the fungal hyphae. Real‐time TaqMan PCR quantification was applied to quantify the fungal hyphae in host tree. The results suggest that inoculation with the fungus significantly improved the survival rate of tested trees. Besides, the number of PWN extracted from fungal inoculated tested trees significantly decreased. Moreover, the fungal hyphae and lunate conidia grown in tested trees were observed with the GFP‐tagged E. vermicola . The real‐time quantification of E. vermicola illustrated the differential distribution of E. vermicola in wilted, wilting and healthy pine trees. Additionally, the promotion of fungal hyphal dispersion by B. xylophilus was found in the pine trees artificially infected with PWN. This study reveals the distribution of E. vermicola and PWN during biocontrol of pine wilt disease and provides direct evidence of the effectiveness of this fungus to control PWN. The migration of PWN infected by E. vermicola was supposed to improve the fungal extension in host pine tree.
    Type of Medium: Online Resource
    ISSN: 1437-4781 , 1439-0329
    URL: Issue
    URL: Article
    DOI: 10.1111/efp.v51.2
    DOI: 10.1111/efp.12668
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2020304-4
    detail.hit.zdb_id: 2232646-7
    SSG: 23
    SSG: 12
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  • 9
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    Total Synthesis of Sculponin U through a Photoinduced Radical Cascade Cyclization
    Wiley ; 2023
    In:  Angewandte Chemie International Edition Vol. 62, No. 29 ( 2023-07-17)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 62, No. 29 ( 2023-07-17)
    Abstract: We have accomplished the total synthesis of sculponin U, a polycyclic C‐20‐oxygenated kaurane diterpenoid featuring a 7,20‐lactone‐hemiketal bridge, through a radical cascade cyclization triggered by photoinduced electron transfer (PET) of a silyl enolate to form the cyclohexanone‐fused bicyclo[3.2.1] octane skeleton. Other key points in our synthetic strategy encompass a Diels–Alder reaction to construct the middle six‐membered ring of sculponin U, and an intramolecular radical cyclization induced by iron‐catalyzed hydrogen atom transfer to close the western cyclohexane ring. Successful preparation of the enantiopure silyl enolate as the PET precursor enables the asymmetric total synthesis of sculponin U, opening a new avenue for divergent syntheses of structurally related C‐20‐oxygenated kaurane congeners and pharmaceutical derivatives thereof.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v62.29
    DOI: 10.1002/anie.202305516
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 10
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    Multi‐Wavelength Quantum Light Sources on Silicon Nitride Micro‐Ring Chip
    Wiley ; 2023
    In:  Laser & Photonics Reviews
    Details
    In: Laser & Photonics Reviews, Wiley
    Abstract: Multi‐wavelength quantum light sources are extremely desired in establishing communication links among multiple users for realizing quantum networks. Despite recent impressive advances, developing such a quantum light source with high quality remains challenging. Here a multi‐wavelength quantum light source using a silicon nitride micro‐ring with a free spectral range of 200 GHz is demonstrated. The generation of eight‐wavelength‐paired photon pairs is ensured in a wavelength range of 25.6 nm. With device optimization and noise‐rejecting filters, this source enables the generation of heralded single‐photons at a rate of 62 kHz with and the generation of energy‐time entangled photons with a visibility of in the Franson interferometer. These results, at room temperature and telecom wavelength, in a CMOS‐compatible platform, represent an important step toward integrated quantum photonic devices, which pave the way for realizing a large‐scale quantum network.
    Type of Medium: Online Resource
    ISSN: 1863-8880 , 1863-8899
    URL: Article
    DOI: 10.1002/lpor.202300172
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2266512-2
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