In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 29, No. 4 ( 2014-04), p. 742-748
Abstract:
This study sought to investigate the effects of hypothermia induced by adenosine 5′‐monophosphate (5′‐ AMP ) on L ‐arginine ( L ‐Arg)‐induced acute pancreatitis in rats. Methods The rats were divided into four groups: the control group, the acute pancreatitis group, the 5′‐ AMP pretreatment group, and the 5′‐ AMP posttreatment group. Rats in all groups, except for the control group, received two injections of 2.5 g/kg body weight (intraperitoneally) L ‐ A rg, with an interval of 1 h between the injections. Subsequently, the rats were observed to assess whether hypothermia induced by 5′‐ AMP could effectively inhibit inflammation associated with L ‐Arg‐induced acute pancreatitis in rats. Results Hypothermia induced by 5′‐ AMP produced protective effects in our acute pancreatitis model. These effects exhibited the following manifestations: (i) a significant reduction in rat mortality rates; (ii) a significant decrease in the occurrence of pancreatic edema; (iii) significant reductions in serum amylase ( P 〈 0.001), interleukin‐6 ( P 〈 0.001), interleukin‐1β ( P 〈 0.001) and tumor necrosis factor‐α ( P 〈 0.001); (iv) the significant inhibition of nuclear factor‐κB (NF‐κB) activation in rats that were pre‐ and posttreated with 5′‐ AMP compared with rats that were only injected with L ‐ A rg; and (v) significant decreases in the occurrence of pancreatic interstitial edema, inflammatory cell infiltration, hemorrhage, and acinar cell necrosis. Conclusions Hypothermia induced by 5′‐ AMP could inhibit the acute inflammatory reaction and NF‐κB activation associated with acute pancreatitis.
Type of Medium:
Online Resource
ISSN:
0815-9319
,
1440-1746
DOI:
10.1111/jgh.2014.29.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
632882-9
detail.hit.zdb_id:
2006782-3
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